KDM2A/FBXL11 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

KDM2A/FBXL11 Antibody [FITC] Summary

Immunogen
A synthetic peptide made to an N-terminal portion of the human KDM2A/FBXL11 protein (between residues 350-500) [UniProt Q9Y2K7]
Localization
Nucleus, nucleoplasm. Note: Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KDM2A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This KDM2A/FBXL11 antibody is useful for Immunocytochemistry/Immunofluorescence where nuclear staining is observed in HeLa cells and IHC-paraffin embedded sections where nuclear staining is seen in human kidney cancer xenograft. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human and mouse

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for KDM2A/FBXL11 Antibody [FITC]

  • [Histone-H3]-lysine-36 demethylase 1A
  • CXXC8F-box protein FBL7
  • CXXC-type zinc finger protein 8
  • FBL11DKFZp434M1735
  • FBL7F-box protein Lilina
  • F-box and leucine-rich repeat protein 11DKFZP434M1735
  • F-box protein FBL11
  • FBXL11FLJ46431
  • FLJ00115
  • JHDM1AF-box/LRR-repeat protein 11
  • JmjC domain-containing histone demethylation protein 1A
  • jumonji C domain-containing histone demethylase 1A
  • KIAA1004EC 1.14.11.27
  • LILINA
  • lysine (K)-specific demethylase 2A
  • lysine-specific demethylase 2A
  • SF-KDM2A

Background

KDM2A / FBXL11 (also known as JHDM1A, lysine specific demethylase 1A) is a F-box family member and JmjC-domain containing histone demethylase that specifically demethylates Lysine 36 of H3 (H3 K36). KDM2A / FBXL11 is involved in epigenetic silencing and required to maintain the heterochromatic state, as well as sustaining centromeric integrity and genomic stability during mitosis (PMID 19001877). Under conditions of starvation, FBXL11's ability to repress RNA transcription has been shown to be reduced (PMID 20379134). In addition, KDM2A / FBXL11 is also a key inhibitory regulator of NF kappa B activity. This regulation occurs when K218 and K221 of the p65 subunit are methylated. The overexpression of KDM2A / FBXL11 can decrease the viability of specific cancer cell lines, while downregulation was shown to have the opposite effect (PMID 20080798). KDM2A / FBXL11 shows further regulatory involvement at CpG islands. Nonmethylated CpG islands preferentially bind KDM2A / FBXL11 using a zinc finger domain, in which the binding is blocked when CpG DNA is in its methlylated form (PMID 20417597).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KDM2A