CXXC4 Antibody - BSA Free

Images

 
Western Blot: CXXC4 Antibody [NBP1-76491] - Human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry-Paraffin: CXXC4 Antibody [NBP1-76491] - Human brain tissue with CXXC4 antibody at 10 ug/mL.
Immunofluorescence: CXXC4 Antibody [NBP1-76491] - Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

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Catalog# & Formulation Size Price

CXXC4 Antibody - BSA Free Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4. The immunogen is located within amino acids 50 - 100 of CXXC4. Amino Acid Squence: NLPERVGTFSAIPALGG
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CXXC4
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunofluorescence 20 ug/ml
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin 10 ug/ml
  • Western Blot 1 ug/ml
Control Peptide
CXXC4 Peptide (NBP1-76491PEP)
Publications
Read Publication using
NBP1-76491 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for CXXC4 Antibody - BSA Free

  • CXXC finger protein 4
  • CXXC-type zinc finger protein 4
  • Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
  • IDAXCXXC finger 4
  • Inhibition of the Dvl and axin complex protein
  • MGC149872

Background

CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for CXXC4 Antibody (NBP1-76491)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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WB
(1)
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Human
(1)
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Showing Publication 1 - 1 of 1.
Publication using NBP1-76491 Applications Species
Olofsen P, Fatrai S, van Strien P et al. Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia Cell Reports Medicine Jan 1 2020 (WB, Human) WB Human

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CXXC4
Uniprot