KDM2A/FBXL11 Antibody [Alexa Fluor® 594]

• Reactivity: Hu, Mu
• Applications: WB, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 594

KDM2A/FBXL11 Antibody [Alexa Fluor® 594] Summary

• Immunogen: A synthetic peptide made to an N-terminal portion of the human KDM2A/FBXL11 protein (between residues 350-500) [UniProt Q9Y2K7]
• Localization: Nucleus, nucleoplasm. Note: Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KDM2A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for KDM2A/FBXL11 Antibody [Alexa Fluor® 594]

• [Histone-H3]-lysine-36 demethylase 1A
• CXXC8
• CXXC8F-box protein FBL7
• CXXC-type zinc finger protein 8
• EC 1.14.11.27
• FBL11
• FBL11DKFZp434M1735
• FBL7
• FBL7F-box protein Lilina
• F-box and leucine-rich repeat protein 11DKFZP434M1735
• F-box protein FBL11
• F-box protein FBL7
• FBXL11
• FBXL11FLJ46431
• FLJ00115
• JHDM1A
• JHDM1AF-box/LRR-repeat protein 11
• JmjC domain-containing histone demethylation protein 1A
• jumonji C domain-containing histone demethylase 1A
• KDM2A
• KDM2A/FBXL11
• KIAA1004
• KIAA1004EC 1.14.11.27
• LILINA
• lysine (K)-specific demethylase 2A
• lysine-specific demethylase 2A
• SF-KDM2A

Background

KDM2A/FBXL11 (F-box and leucine-rich repeat protein 11) is a histone demethylase which has an important role in histone code as well as epigenetic silencing. KDM2A/FBXL11 is known to have interactions with SMAD7, SMAD3, ZNF512B, HIST2H3A and HIST2H3C. KDM2A/FBXL11 has been studied in relation to anemia and Fanconi's anemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KDM2A