KCNN3 Antibody - BSA Free

Western Blot: KCNN3 Antibody - BSA Free [NBP3-46424] - 293T cells were subjected to SDS PAGE followed by western blot with (KCNN3 antibody) at dilution of 1:1000

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

KCNN3 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit KCNN3 Antibody - BSA Free (NBP3-46424) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3. (Uniprot# Q9UGI6)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNN3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence 1:50-1:100
  • Western Blot 1:500-1:1000
• Application Notes: Theoretical Molecular Weight is 50-82 kDa

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for KCNN3 Antibody - BSA Free

• hSK3
• K3
• KCa2.3
• KCa2.3SKCA3small conductance calcium-activated potassium channel protein 3
• KCNN3
• potassium intermediate/small conductance calcium-activated channel, subfamilyN, member 3
• SK3
• SK3K3
• SKCa 3
• SKCa3

Background

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNN3