KAT3B/p300 Antibody (RW128) [DyLight 405]


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Product Details

Reactivity Hu, Mu, Rt, Md, PmSpecies Glossary
Applications WB, ICC/IF
DyLight 405

KAT3B/p300 Antibody (RW128) [DyLight 405] Summary

Fusion protein containing residues 1572-2371 of human KAT3B/p300. [UniProt# Q0947]
The epitope recognized is found between amino acids 1868-1921.
IgG1 Kappa
Protein A purified
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  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
This KAT3B/p300 (RW128) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western Blot, where a band is seen at ~300 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
300 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, mouse, rat, monkey, and mink protein.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Protein A purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for KAT3B/p300 Antibody (RW128) [DyLight 405]

  • E1A binding protein p300
  • E1A-associated protein p300
  • E1A-binding protein, 300kD
  • EC 2.3.1
  • EC
  • EP300
  • histone acetyltransferase p300
  • KAT3B
  • p300 HAT
  • p300
  • RSTS2


In eukaryotic genome, the chromatin dynamicity is crucial for regulation of processes requiring access to genetic information and it is regulated by several different factors including post-translational modifications of histone/non-histone components, especially via acetylation process which is catalyzed by enzymes known as lysine acetyltransferases (KATs). Among different KATs, KAT3B/ p300 and its homologue KAT3A/CBP (CREB-binding protein) are extensively studied KATs with well known cellular functions. KAT3B/ p300 and KAT3A/CBP have been shown to directly interact with several different DNA-binding transcription factors which includes nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Moreover, both KAT3B/p300 and KAT3A/CBP have been shown to exert HAT (histone acetyltransferase) activity, capable of acetylating all four core histone particles in nucleosomes and to play a key role in activating chromatin for transcription. KAT3B/p300 is a potent transcriptional coactivator that has been shown to regulate various biological processes such as cellular proliferation, differentiation, cell cycle, apoptosis, and response to genetic damage, and KAT3B/ p300 dysfunction interfering with these processes implicates in the pathogenesis of several diseases such as cancer, cardiac diseases, diabetes mellitus, and HIV.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies


Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-507APC
Biotin Labeled NB100-507B
DyLight 350 Labeled NB100-507UV
DyLight 488 Labeled NB100-507G
DyLight 550 Labeled NB100-507R
DyLight 650 Labeled NB100-507C
DyLight 680 Labeled NB100-507FR
DyLight 755 Labeled NB100-507IR
FITC Labeled NB100-507F
HRP Labeled NB100-507H
PE Labeled NB100-507PE
PerCP Labeled NB100-507PCP

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Gene Symbol EP300