Kallikrein 1 Antibody [Alexa Fluor® 405]

• Reactivity: Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 405

Kallikrein 1 Antibody [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Kallikrein 5 precursor/Kallikrein 1
  Val23-Arg67(Kallikrein 5 precursor), Ile25-Asp261(Kallikrein 1)
  Accession # NP_081082, P15947
• Specificity: Detects mouse Kallikrein 1 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Kallikrein 1, recombinant mouse (rm) Kallikrein 5 and rmKallikrein 7 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 1 Antibody [Alexa Fluor® 405]

• EC 3.4.21
• EC 3.4.21.35
• glandular kallikrein 1
• hK1
• Kallikrein 1
• kallikrein 1, renal/pancreas/salivary
• kallikrein serine protease 1
• kallikrein-1
• Kidney/pancreas/salivary gland kallikrein
• KLK1
• Klk6
• KLKR
• Tissue kallikrein

Background

The kallikreins are a family of trypsin‑like serine proteases, many of which are associated with a variety of cancers. Kallikrein 1 (KLK1) also known as tissue kallikrein and urinary kallikrein is a 25 - 30 kDa member of peptidase S1 family of proteins. At least two isoforms are predicted. An important physiological function of KLK1 is the cleavage of kininogen to release a vasoactive kinin peptide, bradykinin (for rodent KLK1) or lysyl‑bradykinin (for human KLK1). Kinins regulate vasodilation, blood pressure reduction, smooth muscle relaxation and contraction, pain induction and inflammation.  Over aa 25-261, mouse KLK1 shares 64% aa identity with human KLK1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.