KA1/GRIK4/Glutamate Receptor KA1 Recombinant Protein Antigen

• Reactivity: Hu
• Applications: AC

KA1/GRIK4/Glutamate Receptor KA1 Recombinant Protein Antigen Summary

• Description: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human GRIK4.
  
  

  Source: E. coli

  Amino Acid Sequence: LWTLRHSEATEVSVCQEMVTELRSIILCQDSIH

  Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)

  This product is intended to be used as a blocking antigen for antibody competition assays. Any other use of this antigen is done at the risk of the user. The use of this product for commercial production is strictly prohibited. Please contact technical support if you have any questions.

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein Antigen
• Gene: GRIK4
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • Antibody Competition 10-100 molar excess
• Application Notes: This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP2-62686.

  It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.

  For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com

• Theoretical MW: 21 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS and 1M Urea, pH 7.4.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Alternate Names for KA1/GRIK4/Glutamate Receptor KA1 Recombinant Protein Antigen

• EAA1
• Excitatory amino acid receptor 1
• GluK4
• glutamate receptor KA1
• Glutamate receptor KA-1
• glutamate receptor, ionotropic kainate 4
• glutamate receptor, ionotropic, kainate 4
• GRIK4
• KA1
• KA1GRIK

Background

The GRIK4 gene encodes a glutamate receptor KA-1 protein that is 956 amino acids long, 107 kDA and functions in the major excitatory neurotransmitter in the central nervous system (CNS) by activation of ligand-gated ion channels and G protein-coupled membrane receptors. GRIK4 participate in the neuroactive ligand-receptor interaction, glutamatergic synapse, activation of calcium-permeable kainate receptors, and transmission across chemical synapses. It is known to mainly interact with the GRIK2 gene. Researchers have investigated the role of GRIK4 in bipolar disorder, carcinoma, schizophrenia, parkinson's disease, neuronitis and medulloblastoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: GRIK4