Integrin beta 4/CD104 Antibody (UM-A9) [DyLight 550]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, ICC/IF, IP
Clone
UM-A9
Clonality
Monoclonal
Host
Mouse

Integrin beta 4/CD104 Antibody (UM-A9) [DyLight 550] Summary

Immunogen
Human squamous cell carcinoma (UM-SCC1)
Localization
Cell surface
Specificity
Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
ITGB4
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 550
Format
DyLight 550 (A=562, E=576)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunoprecipitation
Application Notes
Biological Blockade (Partially blocks laminin binding)
Theoretical MW
205 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Alternate Names for Integrin beta 4/CD104 Antibody (UM-A9) [DyLight 550]

  • CD104 antigen
  • CD104
  • GP150
  • Integrin beta 4/CD104
  • integrin beta-4 subunit
  • integrin beta-4
  • integrin, beta 4
  • ITGB4

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Integrin beta 4/CD104 Antibody (NBP2-34507R) (0)

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Secondary Antibodies

 

Isotype Controls

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Diseases for Integrin beta 4/CD104 Antibody (NBP2-34507R)

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol ITGB4
Entrez
Uniprot

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