Integrin beta 4/CD104 Antibody (439-9B) [mFluor Violet 450 SE]

Integrin beta 4/CD104 Antibody (439-9B) [mFluor Violet 450 SE] [NBP1-43369MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum of 445 nm.

• Reactivity: Hu, Bv
• Applications: WB, Flow, IHC, IP
• Clone: 439-9B
• Clonality: Monoclonal
• Host: Rat
• Conjugate: mFluor Violet 450 SE

Integrin beta 4/CD104 Antibody (439-9B) [mFluor Violet 450 SE] Summary

• Additional Information: Clone 439-9B was used by HLDA to establish CD designation.
• Immunogen: The immunogen for this antibody was CD104.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: ITGB4
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Integrin beta 4/CD104 Antibody (439-9B) [mFluor Violet 450 SE]

• CD104 antigen
• CD104
• GP150
• Integrin beta 4
• integrin beta-4 subunit
• integrin beta-4
• integrin, beta 4
• ITGB4

Background

Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ITGB4