Integrin alpha V/CD51 Antibody (EPR5583)

Product Discontinued

Integrin alpha V/CD51 Antibody (EPR5583) Summary

• Immunogen: A synthetic peptide corresponding to residues in the intracellular domain of human CD51 / Integrin alpha-V was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: ITGAV
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-100
  • Western Blot 1:1000-10000
• Theoretical MW: 150 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.05% BSA and 50% Glycerol, pH 7.4
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for Integrin alpha V/CD51 Antibody (EPR5583)

• antigen identified by monoclonal L230
• CD51 antigen
• CD51
• Integrin alpha V
• integrin alpha-V
• integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
• ITGAV
• MSK8
• Vitronectin Receptor alpha
• Vitronectin receptor subunit alpha
• VNRA
• VNRADKFZp686A08142

Background

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing CD51 / Integrin alpha-V undergoes post-translational cleavage to yield disulfide-linked heavy chain (125 kDa) and light chain (25 kDa), which combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the CD51 / Integrin alpha-V, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha V/CD51 Antibody (NBP1-96739)(1)

Publication using NBP1-96739

• Tanaka Satowa, Maekawa Akio, Matsubara Leo et al. Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro. Biochemical and Biophysical Research Communications 2016-01-01 [PMID: 27596966] (WB, WB, Mouse)

Bioinformatics

• Gene Symbol: ITGAV
• Uniprot:
  • P06756()