Integrin alpha 2b/CD41 Antibody (386627) [Alexa Fluor® 594]

• Applications: WB
• Clone: 386627
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 594

Integrin alpha 2b/CD41 Antibody (386627) [Alexa Fluor® 594] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse Integrin α2b/CD41
  Leu32-Arg988
  Accession # NP_034705
• Specificity: Detects mouse Integrin alpha 2b/CD41 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant mouse Integrin alpha 3, -4, -5, -8, -9, or -11.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Integrin alpha 2b (ITGA2b) also known as CD41 and GPIIb, is a transmembrane glycoprotein that is expressed by megakaryocytes and platelets. It is cleaved into two disulfide-linked chains (114 kDa and 22 kDa) during transit through the Golgi. Integrin alpha 2b associates with Integrin beta 3 to form complexes that interact with fibrinogen, von Willebrand factor, fibronectin, and vitronectin. Integrin alpha 2b is required for platelet aggregation, and defects lead to disorders of coagulation. Within the extracellular domain, mouse Integrin alpha 2b shares 81% and 89% amino acid sequence identity with human and rat Integrin alpha 2b, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.