Integrin alpha 1/CD49a Antibody (1090A) [Phycoerythrin]

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HeLa human cervical epithelial carcinoma cell line was stained with Rabbit Anti-Human Integrin alpha 1/CD49a PE‑conjugated Monoclonal Antibody (Catalog # FAB8624P, filled histogram) or isotype control antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
1090A
Clonality
Monoclonal
Host
Rabbit
Conjugate
Phycoerythrin

Integrin alpha 1/CD49a Antibody (1090A) [Phycoerythrin] Summary

Additional Information
Recombinant Monoclonal Antibody.
Immunogen
CHO-S derived rhITGA-1(1-1141/GSL/aT)/C-His + rhITGB-1(21-728/GSL/bT)
Accession # P56199
Specificity
Detects Integrin alpha 1/CD49a by direct elisa.
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
ITGA1
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Integrin alpha 1/CD49a Antibody (1090A) [Phycoerythrin]

  • CD49 antigen-like family member A
  • CD49a antigen
  • CD49a
  • Integrin alpha 1
  • integrin, alpha 1
  • ITGA1
  • Laminin and collagen receptor
  • very late activation protein 1
  • VLA-1
  • VLA1integrin alpha-1

Background

Integrin alpha 1 (also VLA-1, CD49a and Laminin and Collagen Receptor) is a 190‑210 kDa member of the integrin alpha chain family of molecules. It is found on smooth muscle cells, osteoblasts, adipocytes and intestinal epithelium. Integrin  alpha 1 forms a noncovalent heterodimer with Integrin beta 1, and serves as a divalent-cation dependent receptor for collagen types I, IV, VI, XIII and XVI. It also binds the diarrhea-associated NSP4 enterotoxin of rotavirus. Mature human Integrin alpha 1 is a 1151 amino acid (aa) type I transmembrane glycoprotein that contains a 1113 aa extracellular domain (ECD) and a 15 aa cytoplasmic tail. The ECD contains one vWFA/I‑domain (aa 147‑360) that binds collagen, plus multiple divalent cation binding sites. Potential splice variants exist that show a two and four aa substitution for aa 765‑1179. Over aa 29‑1141 (the ECD), human Integrin  alpha 1 shares 88% aa identity with mouse Integrin  alpha 1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ITGA1
Entrez
Uniprot