INSL3 Antibody [DyLight 405]

Product Discontinued

INSL3 Antibody [DyLight 405] Summary

• Immunogen: insulin-like 3 (Leydig cell). (Uniprot# P51460)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: INSL3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for INSL3 Antibody [DyLight 405]

• INSL3
• insulin-like 3 (Leydig cell)
• insulin-like 3
• Ley I-L
• leydig insulin -like hormone
• leydig insulin -like peptide
• Leydig insulin-like peptide
• Ley-I-L
• MGC119818
• MGC119819
• relaxin-like factor b
• Relaxin-like factor
• RLF
• RLFley-I-L
• RLNL

Background

Insulin-like 3 (INSL3), a member of the insulin-like hormone superfamily, is specifically expressed in Leydig cells of the fetal and postnatal testis and in theca cells of the postnatal ovary. It is synthesized as a 131-amino acid preproprotein, which contains a 24-amino acid signal peptide. The human INSL3 gene is assigned to bands p13.2-p12 of the short arm of chromosome 19 with the similar organization to that of insulin and relaxin. INSL3 induces gubernaculum development in an androgen-independent way, while androgen-mediated regression of the CSL occurs independently from Insl3. Moreover, INSL3 is a ligand for LGR8 and INSL3-LGR8 mutations are believed to be associated with human cryptorchidism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: INSL3