ING1 Antibody (585922) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: IHC
• Clone: 585922
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

ING1 Antibody (585922) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human ING1
  Arg70-Ala184
  Accession # Q9UK53
• Specificity: Detects human ING1 in direct ELISAs. In direct ELISAs and Western blots, no cross-reactivity with recombinant human ING2, 3, 4, or 5 is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: ING1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ING1 Antibody (585922) [Janelia Fluor® 669]

• growth inhibitor ING1
• growth inhibitory protein ING1
• ING1
• inhibitor of growth family, member 1
• inhibitor of growth protein 1
• p24ING1c
• p33
• p33ING1
• p33ING1b
• p47
• p47ING1a
• tumor suppressor ING1

Background

p33 ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53-signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. The accession number listed below is for variant (4) that encodes the longest isoform (D). Other synonyms for p33 ING1 include p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a, growth inhibitor ING1, inhibitor of growth 1, tumor suppressor ING1 and growth inhibitory protein ING1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ING1