ING1 Antibody (585915) [Alexa Fluor® 405]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 585915
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

ING1 Antibody (585915) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human ING1
  Arg70-Ala184
  Accession # Q9UK53
• Specificity: Detects human and mouse ING1 in Western blot.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ING1 Antibody (585915) [Alexa Fluor® 405]

• growth inhibitor ING1
• growth inhibitory protein ING1
• ING1
• inhibitor of growth family, member 1
• inhibitor of growth protein 1
• p24ING1c
• p33
• p33ING1
• p33ING1b
• p47
• p47ING1a
• tumor suppressor ING1

Background

ING1 (inhibitor of growth-1) is a member of the ING family of tumor suppressive and apoptosis-promoting epigenetic regulators of chromatin structure. They interact with and alter the ratio of pro- and anti-apoptotic Bcl-2 family members. The p53 tumor suppressor and its downstream targets can potentiate ING1-induced apoptosis. Human isoforms p33ING1, p24ING1c, p33ING1b and p47ING1a vary in N-terminal sequence, resulting in 279, 210, 235 and 422 aa proteins, respectively. The sequence used as an immunogen is common to all isoforms, and shares 83% and 81% amino acid (aa) identity with mouse and rat ING1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.