IL1RAPL2 Antibody (167720) [Unconjugated]

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IL1RAPL2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using Mouse Anti-Human IL1RAPL2 Monoclonal Antibody (Catalog # MAB10071) at 5 µg/mL for 1 hour at room temperature ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
167720
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

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Catalog# & Formulation Size Price

IL1RAPL2 Antibody (167720) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL‑1 RAPL2
Thr17-Glu356
Accession # Q9NP60
Specificity
Detects human IL-1 RAPL2 in ELISA.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-25 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL1RAPL2 Antibody (167720) [Unconjugated]

  • IL-1R10
  • IL-1R-9
  • IL1R9IL-1 receptor accessory protein-like 2
  • IL-1R9IL-1RAPL-2
  • IL1RAPL2
  • IL-1RAPL2
  • IL-1-RAPL-2
  • IL1RAPL-2IL1RAPL-2-related protein
  • interleukin 1 receptor 9
  • interleukin 1 receptor accessory protein-like 2
  • Three immunoglobulin domain-containing IL-1 receptor-related 1
  • TIGIRR-1
  • TIGIRR-1Interleukin-1 receptor 9
  • X-linked interleukin-1 receptor accessory protein-like 2

Background

The Interleukin 1 receptor family (IL-1 R) comprises at least eleven members including IL-1 RI (IL-1 R1), IL-1 RII (IL-1 R2), IL-1 RAcP (IL-1 R3), ST2 (T1/IL-1 R4), IL‑18 R alpha (IL-1 Rrp/IL-1 R5), IL-1 Rrp2 (IL-1 RL2/IL-1 R6), IL‑18 R beta (AcPL/IL-1 R7), IL-1 RAPL1 (TIGIRR-2/IL-1 R8), and IL-1 RAPL2 (TIGIRR-1/IL-1 R9) (1). All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor signaling) domain that is also conserved in the Toll-like receptor family. Related proteins, SIGIRR (single Ig domain-containing IL-1 R-related molecule) and IL‑18BP, differ from the other members by having only one Ig domain (1). IL-1 receptor accessory protein-like 2 (IL-1 RAPL2) is alternately known as IL-1 R9 and three immunoglobulin domain containing IL-1 receptor-related molecule 1 (TIGIRR-1) and is expressed in the brain (2). Its sequence predicts an 686 amino acid (aa) residue type I transmembrane glycoprotein with a 17 aa signal peptide, a 339 aa extracellular region containing three Ig-like domains, an 18 aa transmembrane domain and a 312 aa cytoplasmic tail (3). By comparison to other IL-1 receptor family proteins, IL-1 RAPL2 has a C-terminal cytoplasmic extension beyond the TIR domain that is found in IL-1 RAPL1 and SIGIRR but not other family members (3). Human and mouse IL‑1 RAPL2 share approximately 95% aa sequence identity. Human IL‑1 RAPL2 is most homologous (63%) to IL‑1 RAPL1, a receptor protein that is highly expressed in hippocampus and is involved in X-linked mental retardation (4, 5). Genes for both have been localized to human chromosome Xq22. A ligand for IL-1 RAPL2 has not been identified (1).

  1. Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
  2. Andre, R. et al. (2005) J. Neurochem. 95:324.
  3. Born, T.L. et al. (2000) J. Biol. Chem. 275:29946.
  4. Jin, H. et al. (2000) Eur. J. Hum. Genet. 8:87.
  5. Carrie, A. et al. (1999) Nat. Genet. 23:25.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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