Human IL-4R alpha ELISA Kit (Colorimetric)

• Reactivity: Hu
• Applications: ELISA
• Suitable Sample Type: Serum, Plasma, Cell Culture Supernatant, Cell or Tissue Lysate
• Standard Curve Range: 15.625 - 1000 pg/mL (example only; lot dependent)
• Sensitivity: 9.375 pg/mL (example only; lot dependent)

Human IL-4R alpha ELISA Kit (Colorimetric) Summary

• Description: Assay Length: 4 hours
• Standard Curve Range: 15.625 - 1000 pg/mL (example only; lot dependent)
• Sensitivity: 9.375 pg/mL (example only; lot dependent)
• Assay Type: Sandwich ELISA
• Inter-Assay: %CV < 5.6 (example only; lot dependent)
• Intra-Assay: %CV < 5.7 (example only; lot dependent)
• Spike Recovery: 85 - 99% (example only; lot dependent)
• Sample Volume: 50 - 100 uL
• Kit Type: ELISA Kit (Colorimetric)
• Gene: IL4R

Applications/Dilutions

• Dilutions:
  • ELISA l

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for Human IL-4R alpha ELISA Kit (Colorimetric)

• CD124 antigen
• CD124
• IL-4 R alpha
• IL-4 receptor subunit alpha
• IL4R alpha
• IL-4R alpha
• IL-4R subunit alpha
• IL4R
• IL-4Ra
• IL4RACD124
• IL-4R-alpha
• interleukin 4 receptor
• interleukin-4 receptor alpha chain
• interleukin-4 receptor subunit alpha

Background

IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of na ve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: IL4R