WB, Flow, IHC, B/N, CyTOF-ready, ICC/IFHost:
WB, Flow, CyTOF-readyHost:
Applications: Binding Activity, Bioactivity
IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of na ve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
|Product By Gene ID
- IL-4 receptor subunit alpha
- CD124 antigen
- interleukin-4 receptor subunit alpha
- interleukin-4 receptor alpha chain
- IL-4R subunit alpha
- interleukin 4 receptor
Research Areas for IL-4R alpha
Find related products by research area and learn more about each of the different research areas below.AsthmaCancerImmunology
Bioinformatics Tool for IL-4R alpha
Discover related pathways, diseases and genes to IL-4R alpha. Need help? Read the Bioinformatics Tool Guide
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