IL-18/IL-1F4 Antibody (314811) [Alexa Fluor® 350]

• Reactivity: Ca
• Applications: WB, ICC/IF
• Clone: 314811
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

IL-18/IL-1F4 Antibody (314811) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant canine IL‑18/IL‑1F4
  Tyr37-Ser193
  Accession # Q9XSR0
• Specificity: Detects canine IL‑18/IL‑1F4 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-18/IL-1F4 Antibody (314811) [Alexa Fluor® 350]

• Iboctadekin
• IFN-gamma-inducing factor
• IGIF
• IGIFIL-1 gamma
• IL18
• IL-18
• IL-18MGC12320
• IL-1F4
• IL1F4iboctadekin
• IL-1g
• Interferon gamma-inducing factor
• interleukin 18 (interferon-gamma-inducing factor)
• Interleukin-1 gamma
• interleukin-18

Background

Interleukin 18, also known as interferon-gamma-inducing factor (IGIF) or IL-1 gamma , is an 18 kDa member of the IL-1 superfamily which shares biologic activities with
IL‑12. IL-18 is expressed by liver cells, monocyte/macrophages, osteoblasts and keratinocytes. Mature canine IL-18 shares 73% sequence identity with human IL-18. Caspase-1 (IL-1 beta-converting enzyme) has been shown to process pro-IL-18 to active IL-18. Human IL-18 has been shown to enhance NK cell activity, induce the production of IFN-gamma and GM-CSF and inhibit the production of IL-10 by PBMCs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.