IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

Images

 
Immunohistochemistry-Paraffin: IL-1 RII Antibody (RM0014-7D7) [NB110-85472] - IL1RII immunohistochemistry staining of paraffin sections of mouse Spleen and liver tissues from LPS exposed animals.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
RM0014-7D7
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Format
Azide and BSA Free
Concentration
LYOPH

Order Details

IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free Summary

Immunogen
Mouse IL-1 RII (extracellular domain)
Specificity
This recognizes extracellular domain of mouse IL1R-II protein.
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
IL1R2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:100
  • Western Blot 1:1000

Reactivity Notes

This antibody is reactive against Mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified
Reconstitution Instructions
Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free

  • beta
  • CD121b antigen
  • CD121b
  • IL-1 R beta
  • IL-1 RII
  • IL1R2
  • IL1RBCD121 antigen-like family member B
  • IL-1R-beta
  • IL1RII
  • IL-1RII
  • IL-1RT2
  • IL-1RT-2
  • interleukin 1 receptor, type II
  • Interleukin-1 receptor beta
  • MGC47725

Background

IL-1 receptor type II (IL1R-II) is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a "decoy" receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol IL1R2
Entrez