IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free Summary
Immunogen |
Mouse IL-1 RII (extracellular domain) |
Specificity |
This recognizes extracellular domain of mouse IL1R-II protein. |
Isotype |
IgG2 |
Clonality |
Monoclonal |
Host |
Rat |
Gene |
IL1R2 |
Purity |
Protein A or G purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:50-1:100
- Western Blot 1:1000
|
Reactivity Notes
This antibody is reactive against Mouse.
Packaging, Storage & Formulations
Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
Buffer |
Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS |
Preservative |
No Preservative |
Concentration |
LYOPH |
Purity |
Protein A or G purified |
Reconstitution Instructions |
Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml. |
Alternate Names for IL-1 RII Antibody (RM0014-7D7) - Azide and BSA Free
Background
IL-1 receptor type II (IL1R-II) is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a "decoy" receptor.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Secondary Antibodies
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Isotype Controls
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