IL-1 RII Antibody (RM0014-7D7)

Images

 
Immunohistochemistry-Paraffin: IL-1 RII Antibody (RM0014-7D7) [NB110-85472] - IL1RII immunohistochemistry staining of paraffin sections of mouse Spleen and liver tissues from LPS exposed animals.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
RM0014-7D7
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

IL-1 RII Antibody (RM0014-7D7) Summary

Immunogen
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse Recombinant extracellular domain of mouse IL1R-II protein.
Specificity
This recognizes extracellular domain of mouse IL1R-II protein.
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
IL1R2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-100

Reactivity Notes

This antibody is reactive against Mouse.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein G purified
Reconstitution Instructions
Reconstitute with 0.2 ml sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for IL-1 RII Antibody (RM0014-7D7)

  • beta
  • CD121b antigen
  • CD121b
  • IL-1 R beta
  • IL-1 RII
  • IL1R2
  • IL1RBCD121 antigen-like family member B
  • IL-1R-beta
  • IL1RII
  • IL-1RII
  • IL-1RT2
  • IL-1RT-2
  • interleukin 1 receptor, type II
  • Interleukin-1 receptor beta
  • MGC47725

Background

IL-1 receptor type II (IL1R-II) is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a "decoy" receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF269
Species: Hu
Applications: WB, Flow, CyTOF-ready, Neut
NBP2-16946
Species: Hu, Mu, Po
Applications: WB, IHC, IHC-P
MAB208
Species: Hu
Applications: WB, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
7954-GM/CF
Species: Hu
NB100-56566
Species: Hu, Mu, Rt, Po, Bv
Applications: WB, ChIP, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, CyTOF-ready, ELISA(Cap), Flow-CS, Flow-IC
NB100-524
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
NBP1-84550
Species: Hu
Applications: WB, IHC, IHC-P
AF2940
Species: Hu
Applications: WB, ELISA, Flow, CyTOF-ready
NBP1-82991
Species: Hu, Mu
Applications: WB, IHC, IHC-P

Publications for IL-1 RII Antibody (NB110-85472) (0)

There are no publications for IL-1 RII Antibody (NB110-85472).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for IL-1 RII Antibody (NB110-85472) (0)

There are no reviews for IL-1 RII Antibody (NB110-85472). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for IL-1 RII Antibody (NB110-85472) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for IL-1 RII Antibody (NB110-85472)

Discover related pathways, diseases and genes to IL-1 RII Antibody (NB110-85472). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IL-1 RII Antibody (NB110-85472)

Discover more about diseases related to IL-1 RII Antibody (NB110-85472).
 

Pathways for IL-1 RII Antibody (NB110-85472)

View related products by pathway.

PTMs for IL-1 RII Antibody (NB110-85472)

Learn more about PTMs related to IL-1 RII Antibody (NB110-85472).
 

Research Areas for IL-1 RII Antibody (NB110-85472)

Find related products by research area.

Blogs on IL-1 RII

There are no specific blogs for IL-1 RII, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our IL-1 RII Antibody (RM0014-7D7) and receive a gift card or discount.

Bioinformatics

Gene Symbol IL1R2
Entrez