Orthogonal Strategies: Immunohistochemistry-Paraffin: IKB zeta Antibody [NBP1-89835] - Analysis in human bone marrow and cerebral cortex tissues using NBP1-89835 antibody. Corresponding IKB zeta RNA-seq data are ...read more
Immunohistochemistry-Paraffin: IKB zeta Antibody [NBP1-89835] - Staining of human skeletal muscle shows low positivity in myocytes as expected.
Immunohistochemistry-Paraffin: IKB zeta Antibody [NBP1-89835] - Staining of human bone marrow shows high expression.
Immunohistochemistry-Paraffin: IKB zeta Antibody [NBP1-89835] - Staining of human cerebral cortex shows low expression as expected.
Immunohistochemistry-Paraffin: IKB zeta Antibody [NBP1-89835] - Staining of human recctum shows strong nuclear positivity in lymphoid cells.
This antibody was developed against Recombinant Protein corresponding to amino acids: QGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLL
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Rat (89%). Use in Mouse reported in scientific publication (PMID: 32647171).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2) and 40% Glycerol
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for IKB zeta Antibody
IL-1 inducible nuclear ankyrin-repeat protein
INAPIkappa B-zeta variant 3
Molecule possessing ankyrin repeats induced by lipopolysaccharide
NF-kappa-B inhibitor zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
IkappaBzeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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