IGSF4A/SynCAM1/CADM1 Antibody

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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IGSF4A/SynCAM1/CADM1 Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IGSF4A/SynCAM1
Ile42-Asp376
Accession # NP_061240
Specificity
Detects mouse IGSF4A/SynCAM1 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
Ikbkg
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF1459 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IGSF4A/SynCAM1/CADM1 Antibody

  • BL2
  • Cadm1
  • cell adhesion molecule 1
  • IgSF4
  • IGSF4A
  • IGSF4ADKFZp686F1789
  • IGSF4immunoglobulin superfamily, member 4D variant 2
  • Immunoglobulin superfamily member 4
  • immunoglobulin superfamily, member 4
  • Necl-2
  • NECL2MGC149785
  • nectin-like 2
  • Nectin-like protein 2
  • RA175
  • sgIGSF
  • Spermatogenic immunoglobulin superfamily
  • ST17
  • sTSLC-1
  • Synaptic cell adhesion molecule
  • SynCAM
  • SynCAM1
  • SYNCAMMGC51880
  • TSLC1
  • TSLC-1
  • TSLC1/Nectin-like 2/IGSF4
  • Tumor suppressor in lung cancer 1SYNCAM1

Background

IGSF4A is a 75 kDa immunoglobulin superfamily protein that mediates calcium-independent adhesive interactions, either homophilic or heterophilic with CRTAM (class I-restricted T cell-associated molecule), Necl-1 (SynCAM3) or Nectin-3 (1‑4). Alternate names for IGSF4A reflect its activities. As TSLC-1 (tumor suppressor in lung cancer-1), it is downregulated in non-small cell lung cancer (5). This may allow evasion of antitumor responses, since TSLC-1 interaction with CRTAM on activated NK and CD8+ T cells stimulates cytotoxicity and upregulates IFN-gamma production (3, 6). As Necl-2 (nectin-like 2), it is expressed on T zone-restricted BDCA3+ dendritic cells, again interacting with CRTAM (3). As SynCAM-1 (synaptic cell adhesion molecule-1) it binds homotypically across synaptic clefts and, like neuroligin/neurexin adhesion pairs, promotes formation of neural cell synapses (7, 8). Expression on mast cells allows attachment to neurites and fibroblasts (9, 10). As SgIGSF (spermatogenic IgSF), expression on developing sperm allows adhesion to an unknown partner on Sertoli cells that is critical for normal development (11, 12). Mouse IGSF4A cDNA encodes 445 amino acids including a signal peptide, three Ig-like domains (a V-type, a divergent C1-type and an I-type), a transmembrane domain and a cytoplasmic domain with protein 4.1 and PDZ domain binding sites. These sites allow connections to adaptor molecules and are critical in synaptogenesis (7, 8). The outer Ig-like domain most likely mediates adhesion, with altered affinity for splice variants that have either shorter spacing of this domain from the plasma membrane or varied glycosylation (1, 6). The six reported splice variants include a prominently expressed soluble form of about 45 kDa that inhibits adhesion (13). Mouse IGSF4A ECD shares 99%, 96%, 98% and 88% amino acid identity with rat, human, canine, and bovine IGSF4A, respectively.

  1. Biederer, T. et al. (2006) Genomics 87:139.
  2. Wakayama, T. et al. (2001) Mol. Reprod. Dev. 60:158.
  3. Galibert, L. et al. (2005) J. Biol. Chem. 280:21955.
  4. Shingai, T. et al. (2003) J. Biol. Chem. 278:35421.
  5. Kuramochi, M. et al. (2002) Nat. Genet. 27:427.
  6. Boles, K.S. et al. (2005) Blood 106:779.
  7. Biederer, T. et al. (2002) Science 297:1525.
  8. Sara, Y. et al. (2005) J. Neurosci. 25:260.
  9. Furuno, T. et al. (2005) J. Immunol. 174:6934.
  10. Ito, A. et al. (2003) Blood 101:2601.
  11. Wakayama, T. et al. (2001) Mol. Reprod. Dev. 60:158.
  12. Fujita, E. et al. (2006) Mol. Cell. Biol. 26:718.
  13. Koma, Y. et al. (2004) Oncogene 23:5687.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IGSF4A/SynCAM1/CADM1 Antibody (AF1459)(2)

We have publications tested in 2 confirmed species: Mouse, Bacteria - E. Coli.

We have publications tested in 2 applications: Bioassay, Western Blot.


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Bioassay
(1)
Western Blot
(1)
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Mouse
(1)
Bacteria - E. Coli
(1)
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Secondary Antibodies

 

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Other Available Formats

Biotin BAF1459

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Bioinformatics

Gene Symbol Ikbkg
Uniprot