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Cell adhesion molecule 1 (CADM1) is a brain-specific, immunoglobulin domain. It functions as a homophilic cell adhesion molecule at the synapse. Full-length CADM1 has been shown to induce synaptic assembly, and can sufficiently create a functional postsynaptic response. Therefore, CADM1 antibodies may serve as useful tools for neuroscience and cell-cell interaction studies.