IGFBP-rp1/IGFBP-7 Antibody


Western Blot: IGFBP-rp1/IGFBP-7 Antibody [NBP1-49861] - Analysis of IGFBP7 (aa145-159) in Mouse Kidney lysate (35ug protein in RIPA buffer) using NBP1-49861 at 1ug/ml. Primary incubation was 1 hour. Detected by ...read more

Product Details

Reactivity MuSpecies Glossary
Applications WB, PEP-ELISA
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

IGFBP-rp1/IGFBP-7 Antibody Summary

Peptide with sequence EKAITQVSKGTCEQG corresponding to internal region according to NP_001544.1.
EKAITQVSKGTCEQG - internal region
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
Tris saline, pH 7.3 with 0.5% BSA.
0.02% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified


Application Notes
WB: Approx. 30 kDa band observed in mouse kidney lysates (calculated MW of 29.1 kDa band according to human NP_001544.1 and to mouse NP_032074.3).
Read Publication using NBP1-49861.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human, Rat.

Alternate Names for IGFBP-rp1/IGFBP-7 Antibody

  • angiomodulin
  • FSTL2
  • IBP-7
  • IGFBP7
  • IGFBP-7
  • IGFBP-7PGI2-stimulating factor
  • IGFBP-7v
  • IGFBPrp1
  • IGFBP-rP1
  • insulin-like growth factor binding protein 7
  • insulin-like growth factor-binding protein 7
  • MAC25 protein
  • Mac25
  • MAC25IGF-binding protein 7
  • Prostacyclin-stimulating factor
  • PSF
  • TAF
  • Tumor-derived adhesion factor


Observational study of gene-disease association. (HuGE Navigator. A genome-wide RNA-interference screening to identify genes required for an activated BRAF oncogene to block proliferation of fibroblasts and melanocytes revealed that a IGFBP7, has a central role in BRAF-mediated senescence and apoptosis. This study supports the role of IGFBP-1, -3 and -7 as potential tumour suppressor genes in human breast cancer. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Expression in tumor cells may reduce the anchorage-independent growth ability, leading to the marked loss of tumorigenicity. discovered the implication of insulin-like growth factor-binding protein-related protein 1 in endometrial physiology, which seems related to endometrial receptivity. data suggest that mac25/IGFBP-rP1 and 25.1 may play a functional role in the NE differentiation of NSCLC cell lines and may provide a novel therapeutic target for treating lung cancers, in particular NSCLC with NE differentiation. findings show for the first time that circulating IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) is increased with insulin resistance. that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. mRNA expression was lost in six out of eight CRC cell lines as compared to normal colon cells. DNA methylation was found in the region of exon 1 and intron 1 of IGFBP-7. tumor-suppressive activity is through induction of apoptosis in an IGF-I independent manner in prostate cancer. SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation. In prostate cancer cells, one of the downstream mediators of the senescence-associated tumor suppression effect of mac25/IGFBP-rP1 is superoxide dismutase 2


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IGFBP-rp1/IGFBP-7 Antibody (NBP1-49861)(1)

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Video Protocols

WB Video Protocol

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Secondary Antibodies


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Product PDFs


Gene Symbol IGFBP7

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