IGFBP-rp1/IGFBP-7 Products

Antibodies
IGFBP-rp1/IGFBP-7 Antibody (4 ...
IGFBP-rp1/IGFBP-7 Antibody (40012B...
MAB13341
Species: Hu
Applications: IHC
Host: Goat Monoclonal
IGFBP-rp1/IGFBP-7 Antibody [U ...
IGFBP-rp1/IGFBP-7 Antibody [Unconj...
AF1334
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
IGFBP-rp1/IGFBP-7 Antibody (1 ...
IGFBP-rp1/IGFBP-7 Antibody (192520...
MAB1334
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
IGFBP-rp1/IGFBP-7 Overexpress ...
IGFBP-rp1/IGFBP-7 Overexpression L...
NBP2-08191
Applications: WB
Proteins
Human IGFBP-rp1/IGFBP-7 Prote ...
Human IGFBP-rp1/IGFBP-7 Protein
NBP2-35007
Species: Hu
Applications: Func, PAGE
IGFBP-rp1/IGFBP-7 Recombinant ...
IGFBP-rp1/IGFBP-7 Recombinant Prot...
NBP1-83415PEP
Species: Hu
Applications: AC
IGFBP-rp1/IGFBP-7 Recombinant ...
IGFBP-rp1/IGFBP-7 Recombinant Protein
NBP2-23142
Species: Hu
Applications: PAGE

Description

Observational study of gene-disease association. (HuGE Navigator. A genome-wide RNA-interference screening to identify genes required for an activated BRAF oncogene to block proliferation of fibroblasts and melanocytes revealed that a IGFBP7, has a central role in BRAF-mediated senescence and apoptosis. This study supports the role of IGFBP-1, -3 and -7 as potential tumour suppressor genes in human breast cancer. IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis. Expression in tumor cells may reduce the anchorage-independent growth ability, leading to the marked loss of tumorigenicity. discovered the implication of insulin-like growth factor-binding protein-related protein 1 in endometrial physiology, which seems related to endometrial receptivity. data suggest that mac25/IGFBP-rP1 and 25.1 may play a functional role in the NE differentiation of NSCLC cell lines and may provide a novel therapeutic target for treating lung cancers, in particular NSCLC with NE differentiation. findings show for the first time that circulating IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) is increased with insulin resistance. that IGFBP-rP1 is an inhibitor of MCF-7 breast cancer cell proliferation and may act via a cellular senescence-like mechanism. IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. mRNA expression was lost in six out of eight CRC cell lines as compared to normal colon cells. DNA methylation was found in the region of exon 1 and intron 1 of IGFBP-7. tumor-suppressive activity is through induction of apoptosis in an IGF-I independent manner in prostate cancer. SOX9 contributes to growth regulation by mac25 via inhibition of cell growth and promotion of differentiation. In prostate cancer cells, one of the downstream mediators of the senescence-associated tumor suppression effect of mac25/IGFBP-rP1 is superoxide dismutase 2

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 3490
Alternate Names
  • MAC25 protein
  • IGFBP-rP1
  • insulin-like growth factor-binding protein 7
  • IBP-7
  • angiomodulin
  • Tumor-derived adhesion factor
  • IGFBPRP1
  • Prostacyclin-stimulating factor
  • IGFBP-7v
  • FSTL2
  • PSFAGM
  • IGFBP-7PGI2-stimulating factor
  • MAC25IGF-binding protein 7
  • TAF
  • insulin-like growth factor binding protein 7

PTMs for IGFBP-rp1/IGFBP-7

Learn more about PTMs related to IGFBP-rp1/IGFBP-7.

Methylation
Phosphorylation
Demethylation
Cleavage

Bioinformatics Tool for IGFBP-rp1/IGFBP-7

Discover related pathways, diseases and genes to IGFBP-rp1/IGFBP-7. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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