IGFALS/ALS Antibody

Product Discontinued

IGFALS/ALS Antibody Summary

• Immunogen: Peptide with sequence C-GLDLRDLSEAH corresponding to C-Terminus according to NP_004961.1.
• Epitope: C-Terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IGFALS
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
• Application Notes: WB: Preliminary experiments gave an approx. 45 kDa band in lysates of HepG2 after 2 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 66.0 kDa band according to NP_004961.1. The 45 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for IGFALS/ALS Antibody

• ALS insulin-like growth factor binding protein complex acid labile chain
• ALS
• insulin-like growth factor binding protein, acid labile subunit
• insulin-like growth factor-binding protein complex acid labile subunit

Background

The protein encoded by the IGFALS gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IGFALS/ALS Antibody (NBP1-47208)(1)

Publication using NBP1-47208

• Hosgood HD, Menashe I, Shen M et al. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Carcinogenesis 2008-10-01 [PMID: 18676680]

Bioinformatics

• Gene Symbol: IGFALS
• Entrez:
  • 3483(Human)
  • 16005(Mouse)
  • 79438(Rat)
• Uniprot:
  • NP_004961.1(Human)