IGFALS/ALS Products

Description

The protein encoded by the IGFALS gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq)

Bioinformatics

Entrez	3483 Human
Uniprot	NM_004970 Human AAH25681.1 Human P35858 Human P70389 Mouse
Product By Gene ID	3483
Alternate Names	ALS insulin-like growth factor binding protein complex acid labile chain ALS insulin-like growth factor-binding protein complex acid labile subunit insulin-like growth factor binding protein, acid labile subunit

Diseases related to IGFALS/ALS

Discover more about diseases related to IGFALS/ALS.

Growth Disorders
Dwarfism
Shwachman Syndrome
Malignant Neoplasms
Growth Retardation
Mammary Neoplasms
Insulin Resistance
Malignant Neoplasm Of Breast
Neoplasms
Malnutrition
Microcephaly
Delayed Puberty
Atrophy
Heart Diseases
Prostatic Neoplasms
Uniparental Disomy
Cardiovascular Diseases
Laron Syndrome
Malignant Neoplasm Of Prostate

Pathways for IGFALS/ALS

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Secretion
Methylation
Transport
Cell Proliferation
Gene Silencing
Carbohydrate Homeostasis
Histone Acetylation
Glycosylation
Menopause
Cell Growth
Regulation Of Cell Growth

PTMs for IGFALS/ALS

Learn more about PTMs related to IGFALS/ALS.

Glycosylation
Acetylation
Methylation

Bioinformatics Tool for IGFALS/ALS

Discover related pathways, diseases and genes to IGFALS/ALS. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.