Recombinant Human IFN-gamma R2 Protein

Product Discontinued

Recombinant Human IFN-gamma R2 Protein Summary

• Description: A recombinant protein corresponding to IFNGR2. The purity of this protein is >95% pure by SDS-PAGE
• Preparation Method: Recombinant Human IFN-gamma is produced in E.Coli
• Details of Functionality: 2 x 107 NIH Gg 23-901-530 units/mg. Biological activity has been assessed in a bioassay using inhibition of the cytopathic encephalomyocarditis virus effect on human lung carcinoma cell line A549 as test parameter.
• Protein/Peptide Type: Recombinant Protein
• Gene: IFNGR2

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
• Application Notes: This protein is useful for ELISA and Flow Cytometry

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 10 mg/ml BSA.
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute with 1.1 ml of distilled water.

Alternate Names for Recombinant Human IFN-gamma R2 Protein

• AF-1
• AF-1interferon-gamma receptor beta chain precursor10IFNGT1Interferon gamma receptor accessory factor 1
• IFGR2
• IFN-gamma R2
• IFN-gamma receptor 2
• IFNgammaR2
• IFN-gamma-R2
• IFNGR2
• IFN-gR2
• IFNGT1
• interferon gamma receptor 2 (interferon gamma transducer 1)
• interferon gamma receptor 2
• interferon gamma receptor accessory factor-1
• interferon gamma receptor beta chain
• Interferon gamma transducer 1

Background

Recombinant Human IFN-gamma produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 144 amino acids and having a molecular mass of 16879 Dalton. IFN-gamma, also called Type II interferon, is a homodimeric glycoprotein containing approximately 21 to 24 kD subunits. The human IFN-gamma gene, situated on chromosome 12, contains three introns; the four exons code for a polypeptide of 166 amino acids, 20 of which constitute the signal peptide. In contrast to IFN-alpha and IFN-beta synthesis, which can occur in any cell, production of IFN-gamma is a function of T cells and NK cells. IFN-gamma has antiviral and antiparasitic activities and also inhibits the proliferation of a number of normal and transformed cells. IFN-gamma synergises with TNF-alpha and TNF-beta in inhibiting the proliferation of various cell types.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IFNGR2