Western Blot: IFIT2 Antibody [NBP2-15180] - Analysis of IFIT2 in human K562 lysate in the 1) absence and 2) presence of immunizing peptide, and 3) mouse RAW lysate probed with 4 ug/ml of IFIT2 antibody. Goat anti-rabbit ...read more
Immunocytochemistry/ Immunofluorescence: IFIT2 Antibody [NBP2-15180] - SK-MEL-28 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton-X100. The cells were ...read more
The IFIT2 amino acid sequence used as immunogen for this antibody is 94% in new world monkey, rhesus monkey, white-cheeked gibbon, chimpanzee, and orangutan, 72% in cow, dog, chinese hamster, mole rat, and rabbit, 66% in mouse, and 61% homologouus in pig.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.05% Sodium Azide
Protein A purified
Alternate Names for IFIT2 Antibody
Interferon, alpha-inducible protein (MW 54kD)
Interferon-induced 54 kDa protein
interferon-induced protein 54
interferon-induced protein with tetratricopeptide repeats 2
IFIT2, or IFIT2/SG54, has been identified as a 54kDa protein and an important component of the TLR signaling family and ISG family of proteins induced by Type 1 Interferons. IFIT2 is one of three members of tetraticopeptide repeat (IFIT) gene in mice. IFIT2 knockout mice succumb to intranasal VSV infection exhibiting neurological patterns such as ataxia before death. This is caused by spread from olfactory lobes to other brain regions where VSV titers rise over a hundred-fold in IFIT2 knockout but not in wild-type mice. IFIT1 knockouts and WT mice survive IN injection. Additionally in West Nile Virus infections ISGs and IFIT2 in particular appear to drive the protective IFN Type I responses. IKKe induces STAT1 phosphorylation which drives IFIT expression mediating IFN anti-WNV effects. WNV replicates unabatedly in cells from IKKe-/- or IFIT2-/- mice. STAT1 phosphorylation is greatly diminished in these mice. Antibody to IFIT2 provides a useful probe to further characterize its specific antiviral and IFN mediating role as shown in the aforementioned models.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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