IFIT2 Antibody

Images

 
Western Blot: IFIT2 Antibody [NBP2-15180] - Analysis of IFIT2 in human K562 lysate in the 1) absence and 2) presence of immunizing peptide, and 3) mouse RAW lysate probed with 4 ug/ml of IFIT2 antibody. Goat anti-rabbit ...read more
Immunocytochemistry/ Immunofluorescence: IFIT2 Antibody [NBP2-15180] - SK-MEL-28 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X PBS + 0.05% Triton-X100. The cells were ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

IFIT2 Antibody Summary

Immunogen
A portion of amino acids 320-370 from human IFIT2 was used as the immunogen for this antibody.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IFIT2
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2-5 ug/ml
  • Immunocytochemistry/Immunofluorescence 5-10 ug/ml
Publications
Read Publication using NBP2-15180.

Reactivity Notes

The IFIT2 amino acid sequence used as immunogen for this antibody is 94% in new world monkey, rhesus monkey, white-cheeked gibbon, chimpanzee, and orangutan, 72% in cow, dog, chinese hamster, mole rat, and rabbit, 66% in mouse, and 61% homologouus in pig.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A purified

Alternate Names for IFIT2 Antibody

  • cig42
  • G10P2IFI-54K
  • GARG-39
  • IFI-54
  • IFI54IFIT-2
  • IFI-54K
  • Interferon, alpha-inducible protein (MW 54kD)
  • Interferon-induced 54 kDa protein
  • interferon-induced protein 54
  • interferon-induced protein with tetratricopeptide repeats 2
  • ISG-54 K
  • ISG54
  • ISG-54K
  • P54

Background

IFIT2, or IFIT2/SG54, has been identified as a 54kDa protein and an important component of the TLR signaling family and ISG family of proteins induced by Type 1 Interferons. IFIT2 is one of three members of tetraticopeptide repeat (IFIT) gene in mice. IFIT2 knockout mice succumb to intranasal VSV infection exhibiting neurological patterns such as ataxia before death. This is caused by spread from olfactory lobes to other brain regions where VSV titers rise over a hundred-fold in IFIT2 knockout but not in wild-type mice. IFIT1 knockouts and WT mice survive IN injection. Additionally in West Nile Virus infections ISGs and IFIT2 in particular appear to drive the protective IFN Type I responses. IKKe induces STAT1 phosphorylation which drives IFIT expression mediating IFN anti-WNV effects. WNV replicates unabatedly in cells from IKKe-/- or IFIT2-/- mice. STAT1 phosphorylation is greatly diminished in these mice. Antibody to IFIT2 provides a useful probe to further characterize its specific antiviral and IFN mediating role as shown in the aforementioned models.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

MAB17761
Species: Hu, Mu, Rt
Applications: WB, ICC
NBP2-67360
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
NB200-191
Species: Hu, Mu, Ha
Applications: WB, ICC/IF, IHC, IHC-P, IP
NBP2-02340
Species: Hu, Mu, Rt, Mk
Applications: WB, Flow, ICC/IF, IHC, IHC-P
NB100-1556
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP, ICC
NBP2-22203
Species: Hu, Mu, Rt, Mk
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
NBP2-67471
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
H00080122-M01
Species: Hu
Applications: ELISA, ICC/IF
NBP1-92392
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-32500
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-19985
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-20329
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
AF8691
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, KO
NBP2-75930
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P
NB100-74360
Species: Hu, Mu
Applications: WB, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IP
AF1334
Species: Hu
Applications: WB, IHC
AF467
Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, ICC
NBP1-68874
Species: Hu, Mu, Rt
Applications: WB, PEP-ELISA
Supplier Logo

Publications for IFIT2 Antibody (NBP2-15180)(1)

We have publications tested in 1 confirmed species: Mouse.


Filter By Application
All Applications
Filter By Species
Mouse
(1)
All Species

Reviews for IFIT2 Antibody (NBP2-15180) (0)

There are no reviews for IFIT2 Antibody (NBP2-15180). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for IFIT2 Antibody (NBP2-15180) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional IFIT2 Products

Bioinformatics Tool for IFIT2 Antibody (NBP2-15180)

Discover related pathways, diseases and genes to IFIT2 Antibody (NBP2-15180). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for IFIT2 Antibody (NBP2-15180)

Discover more about diseases related to IFIT2 Antibody (NBP2-15180).
 

Pathways for IFIT2 Antibody (NBP2-15180)

View related products by pathway.

PTMs for IFIT2 Antibody (NBP2-15180)

Learn more about PTMs related to IFIT2 Antibody (NBP2-15180).

Blogs on IFIT2.

STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...  Read full blog post.

Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our IFIT2 Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol IFIT2
Uniprot
Novus 100% Guarantee