Human TRANCE/RANK L/TNFSF11 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human TRANCE/RANK L/TNFSF11 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFSF11

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TRANCE/RANK L/TNFSF11 DuoSet ELISA, 15 Plate

• CD254 antigen
• CD254
• ODF
• OPGL
• OPGLOPTB2
• Osteoclast differentiation factor
• Osteoprotegerin ligand
• RANK L
• RANKL
• RANKLreceptor activator of nuclear factor kappa B ligand
• Receptor activator of nuclear factor kappa-B ligand
• sOdf
• TNF-related activation-induced cytokine
• TNFSF11
• TRANCE
• TRANCEODFhRANKL2
• tumor necrosis factor (ligand) superfamily, member 11
• tumor necrosis factor ligand superfamily member 11

Background

TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland.

Publications for TRANCE/TNFSF11/RANK L (DY626)(27)

Publications using DY626

• Melano, I;Azamor, T;Caetano, CC;Meyer, NM;Onwubueke, C;Visperas, A;Familiar-Macedo, D;Salem, GM;Soos, BL;Calabrese, CM;Choi, YJ;Chen, S;Choi, Y;Wu, X;Vasconcelos, Z;Comhair, SA;Nielsen-Saines, K;Calabrese, LH;Husni, ME;Jung, JU;Piuzzi, NS;Foo, SS;Chen, W; SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases JCI insight 2024-12-20 [PMID: 39704167] (Human)
• Ozkal Eminoglu, D;Arabaci, T;Oztas Sahiner, GA; The effect of titanium-platelet rich fibrin on periodontal intrabony defects: A randomized controlled split-mouth clinical study PloS one 2024-06-06 [PMID: 38843242] (Human)
• Jiang, J;Röper, L;Fuchs, F;Hanschen, M;Failer, S;Alageel, S;Cong, X;Dornseifer, U;Schilling, AF;Machens, HG;Moog, P; Bone Regenerative Effect of Injectable Hypoxia Preconditioned Serum-Fibrin (HPS-F) in an Ex Vivo Bone Defect Model International journal of molecular sciences 2024-05-13 [PMID: 38791352] (Human)
• Gasparotto, M;Di Pierro, G;Toffoli, B;Grillo, A;Bressan, M;Fiorentin, M;Di Luozzo, L;Fischetti, F;Zen, M;Fabris, B;Bernardi, S;Tomietto, P; Preliminary Study on Pulse Wave Changes in Patients with Inflammatory Arthropathies Treated with bDMARDs Journal of clinical medicine 2024-05-02 [PMID: 38731213] (Human)
• N Lu, C Shan, JR Fu, Y Zhang, YY Wang, YC Zhu, J Yu, J Cai, SX Li, T Tao, W Liu RANKL Is Independently Associated with Increased Risks of Non-Alcoholic Fatty Liver Disease in Chinese Women with PCOS: A Cross-Sectional Study Journal of Clinical Medicine, 2023-01-05;12(2):. 2023-01-05 [PMID: 36675380] (Human)
• J Pape, D Bakkalci, RA Hosni, BS Simpson, K Heikinheim, S Fedele, U Cheema RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model Journal of tissue engineering, 2022-12-24;13(0):2041731422114. 2022-12-24 [PMID: 36582941] (Human)
• KEC Blokland, M Nizamoglu, H Habibie, T Borghuis, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts Frontiers in Pharmacology, 2022-11-03;13(0):989169. 2022-11-03 [PMID: 36408252] (Human)
• T Nicholson, L Davis, ET Davis, M Newton Ede, A Scott, SW Jones e-Cigarette Vapour Condensate Reduces Viability and Impairs Function of Human Osteoblasts, in Part, via a Nicotine Dependent Mechanism Toxics, 2022-08-28;10(9):. 2022-08-28 [PMID: 36136470] (Human)
• J Jiang, L Röper, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog Hypoxia Preconditioned Serum (HPS) Promotes Osteoblast Proliferation, Migration and Matrix Deposition Oncogene, 2022-07-07;10(7):. 2022-07-07 [PMID: 35884936] (Human)
• S Passaponti, L Ermini, G Acconci, FM Severi, R Romagnoli, S Cutrupi, M Clerico, G Guerrera, F Ietta Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta Cells, 2022-04-15;11(8):. 2022-04-15 [PMID: 35456036] (Human)
• N Al-Hamoudi, Y Alali, K Al-Aali, AA Alhumaidan, E Heer, SA Tanveer, M Naseem, F Vohra, T Abduljabba Peri-implant parameters and bone metabolic markers among water-pipe users treated with photodynamic therapy Photodiagnosis and photodynamic therapy, 2021-11-28;37(0):102655. 2021-11-28 [PMID: 34852310] (Human)
• KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM Cells, 2021-06-29;10(7):. 2021-06-29 [PMID: 34209854] (Human)
• B Shetty, DD Divakar, AA Al-Kheraif, AO Alharbi, MST Almutairi, MM Alanazi Role of PDT as an adjunct to SRP on whole salivary RANKL and OPG ratio in type-2 diabetic and normoglycemic individuals with chronic periodontitis Photodiagnosis and photodynamic therapy, 2021-02-18;0(0):102220. 2021-02-18 [PMID: 33610736] (Human)
• A Radujkovic, T Boch, F Nolte, D Nowak, C Kunz, A Gieffers, C Müller-Tid, P Dreger, WK Hofmann, T Luft Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile Cancers, 2020-12-08;12(12):. 2020-12-08 [PMID: 33302451] (Human)
• J Aldridge, AH Ekwall, L Mark, B Bergström, K Andersson, I Gjertsson, AC Lundell, A Rudin T helper cells in synovial fluid of patients with rheumatoid arthritis primarily have a Th1 and a CXCR3+Th2 phenotype Arthritis Res Ther, 2020-10-16;22(1):245. 2020-10-16 [PMID: 33066816] (Human)
• S Bernardi, B Toffoli, F Tonon, M Francica, E Campagnolo, T Ferretti, S Comar, F Giudici, E Stenner, B Fabris Sex Differences in Proatherogenic Cytokine Levels Int J Mol Sci, 2020-05-29;21(11):. 2020-05-29 [PMID: 32485823] (Human)
• IJ Yeh, SC Chen, MC Yen, YH Wu, CH Hung, PL Kuo 6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential Nutrients, 2019-09-28;11(10):. 2019-09-28 [PMID: 31569368] (Human)
• S Benjakul, C Leethanaku, S Jitpukdeeb Low magnitude high frequency vibration induces RANKL via cyclooxygenase pathway in human periodontal ligament cells in vitro J Oral Biol Craniofac Res, 2019-06-04;9(3):251-255. 2019-06-04 [PMID: 31211043] (Human)
• C Chatmahamo, A Pravithara, S Suttapreya, C Leethanaku The effect of compressive force combined with mechanical vibration on human alveolar bone osteoblasts J Oral Biol Craniofac Res, 2018-10-16;9(1):81-85. 2018-10-16 [PMID: 30997326] (Human)
• BD Sui, J Chen, XY Zhang, T He, P Zhao, CX Zheng, M Li, CH Hu, Y Jin Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery Exp. Mol. Med., 2018-12-17;50(12):166. 2018-12-17 [PMID: 30559383] (Human)
• J Panezai, A Ghaffar, M Altamash, PE Engström, A Larsson Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis PLoS ONE, 2018-06-11;13(6):e0197235. 2018-06-11 [PMID: 29889832] (Human)
• A A Ochanji, N K Matu, T K Mulli Association of salivary RANKL and osteoprotegerin levels with periodontal health. Clinical and Experimental Dental Research, 2017-04-12;0(0):2057-4347. 2017-04-12 [PMID: 29744178] (Human)
• C Davenport, E Harper, KD Rochfort, H Forde, D Smith, PM Cummins RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain J. Vasc. Res., 2018-04-10;55(2):111-123. 2018-04-10 [PMID: 29635231] (Human)
• AA Elmusrati, AE Pilborough, SA Khurram, DW Lambert Cancer-associated fibroblasts promote bone invasion in oral squamous cell carcinoma Br. J. Cancer, 2017-07-25;117(6):867-875. 2017-07-25 [PMID: 28742795] (Human)
• Sang-Hun Shin Effect of low-level laser therapy on bisphosphonate-treated osteoblasts Maxillofac Plast Reconstr Surg, 2016-11-25;38(1):48. 2016-11-25 [PMID: 27995121] (Human)
• XZ Wang, XY Sun, CY Zhang, X Yang, WJ Yan, LH Ge, SG Zheng RUNX2 Mutation Impairs 1?,25-Dihydroxyvitamin D3 mediated Osteoclastogenesis in Dental Follicle Cells Sci Rep, 2016-04-12;6(0):24225. 2016-04-12 [PMID: 27068678] (Human)
• El Azreq M, Arseneault C, Boisvert M, Page N, Allaeys I, Poubelle P, Tessier P, Aoudjit F Cooperation between IL-7 Receptor and Integrin alpha2beta1 (CD49b) Drives Th17-Mediated Bone Loss. J Immunol, 2015-09-25;195(9):4198-209. 2015-09-25 [PMID: 26408663] (Human)

FAQs for TRANCE/TNFSF11/RANK L (DY626). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: TNFSF11