Human TRANCE/RANK L/TNFSF11 DuoSet ELISA, 15 Plate



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Reactivity HuSpecies Glossary
Applications ELISA

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Human TRANCE/RANK L/TNFSF11 DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using DY626.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TRANCE/RANK L/TNFSF11 DuoSet ELISA, 15 Plate

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11


TRANCE (TNF-related activation-induced cytokines), also known as RANK Ligand, OPGL, or ODF, is a TNF superfamily ligand produced by osteoblasts, bone marrow stromal cells, and activated T cells. It signals through RANK and is antagonized by the decoy receptor Osteoprotegerin. TRANCE stimulates bone resorption, is required for osteoclast differentiation, and is associated with the development of osteoporosis, vascular calcification, osteopetrosis, and progestin-induced breast cancer. It also mediates body temperature regulation and is essential for the development of a lactating mammary gland.

Publications for TRANCE/TNFSF11/RANK L (DY626)(23)

We have publications tested in 1 confirmed species: Human.

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Showing Publications 1 - 10 of 23. Show All 23 Publications.
Publications using DY626 Applications Species
N Lu, C Shan, JR Fu, Y Zhang, YY Wang, YC Zhu, J Yu, J Cai, SX Li, T Tao, W Liu RANKL Is Independently Associated with Increased Risks of Non-Alcoholic Fatty Liver Disease in Chinese Women with PCOS: A Cross-Sectional Study Journal of Clinical Medicine, 2023-01-05;12(2):. 2023-01-05 [PMID: 36675380] (Human) Human
J Pape, D Bakkalci, RA Hosni, BS Simpson, K Heikinheim, S Fedele, U Cheema RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model Journal of tissue engineering, 2022-12-24;13(0):2041731422114. 2022-12-24 [PMID: 36582941] (Human) Human
KEC Blokland, M Nizamoglu, H Habibie, T Borghuis, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts Frontiers in Pharmacology, 2022-11-03;13(0):989169. 2022-11-03 [PMID: 36408252] (Human) Human
T Nicholson, L Davis, ET Davis, M Newton Ede, A Scott, SW Jones e-Cigarette Vapour Condensate Reduces Viability and Impairs Function of Human Osteoblasts, in Part, via a Nicotine Dependent Mechanism Toxics, 2022-08-28;10(9):. 2022-08-28 [PMID: 36136470] (Human) Human
J Jiang, L Röper, S Alageel, U Dornseifer, AF Schilling, E Hadjipanay, HG Machens, P Moog Hypoxia Preconditioned Serum (HPS) Promotes Osteoblast Proliferation, Migration and Matrix Deposition Oncogene, 2022-07-07;10(7):. 2022-07-07 [PMID: 35884936] (Human) Human
S Passaponti, L Ermini, G Acconci, FM Severi, R Romagnoli, S Cutrupi, M Clerico, G Guerrera, F Ietta Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta Cells, 2022-04-15;11(8):. 2022-04-15 [PMID: 35456036] (Human) Human
N Al-Hamoudi, Y Alali, K Al-Aali, AA Alhumaidan, E Heer, SA Tanveer, M Naseem, F Vohra, T Abduljabba Peri-implant parameters and bone metabolic markers among water-pipe users treated with photodynamic therapy Photodiagnosis and photodynamic therapy, 2021-11-28;37(0):102655. 2021-11-28 [PMID: 34852310] (Human) Human
KEC Blokland, H Habibie, T Borghuis, GJ Teitsma, M Schuliga, BN Melgert, DA Knight, CA Brandsma, SD Pouwels, JK Burgess Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM Cells, 2021-06-29;10(7):. 2021-06-29 [PMID: 34209854] (Human) Human
B Shetty, DD Divakar, AA Al-Kheraif, AO Alharbi, MST Almutairi, MM Alanazi Role of PDT as an adjunct to SRP on whole salivary RANKL and OPG ratio in type-2 diabetic and normoglycemic individuals with chronic periodontitis Photodiagnosis and photodynamic therapy, 2021-02-18;0(0):102220. 2021-02-18 [PMID: 33610736] (Human) Human
A Radujkovic, T Boch, F Nolte, D Nowak, C Kunz, A Gieffers, C Müller-Tid, P Dreger, WK Hofmann, T Luft Clinical Response to the CD95-Ligand Inhibitor Asunercept Is Defined by a Pro-Inflammatory Serum Cytokine Profile Cancers, 2020-12-08;12(12):. 2020-12-08 [PMID: 33302451] (Human) Human
Show All 23 Publications.

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Additional TRANCE/TNFSF11/RANK L Products


The diverse functions of RANKL/TRANCE/TNFSF11
RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...  Read full blog post.

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Gene Symbol TNFSF11