Human TRAIL/TNFSF10 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human TRAIL/TNFSF10 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFSF10

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TRAIL/TNFSF10 DuoSet ELISA, 15 Plate

• Apo-2 ligand
• APO2L
• Apo-2Ltumor necrosis factor (ligand) family, member 10
• APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta
• CD253 antigen
• CD253
• Protein TRAIL
• TL2
• TNF-related apoptosis-inducing ligand
• TNFSF10
• TRAIL
• TRAILTNF-related apoptosis inducing ligand TRAIL
• tumor necrosis factor (ligand) superfamily, member 10
• tumor necrosis factor ligand superfamily member 10

Background

TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. Among TNF superfamily members, TRAIL is the most homologous to Fas Ligand, sharing 28% amino acid sequence identity in their extracellular domains. Human TRAIL shares 65% amino acid sequence identity with mouse TRAIL and is active on mouse cells.

Publications for TRAIL/TNFSF10 (DY375)(7)

Publications using DY375

• Menevse, AN;Ammer, LM;Vollmann-Zwerenz, A;Kupczyk, M;Lorenz, J;Weidner, L;Hussein, A;Sax, J;M�hlbauer, J;Heuschneider, N;Rohrmus, C;Mai, LS;Jachnik, B;Stamova, S;Volpin, V;Durst, FC;Sorrentino, A;Xydia, M;Milenkovic, VM;Bader, S;Braun, FK;Wetzel, C;Albert, NL;Tonn, JC;Bartenstein, P;Proescholdt, M;Schmidt, NO;Linker, RA;Riemenschneider, MJ;Beckhove, P;Hau, P; TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma Acta neuropathologica communications 2023-05-08 [PMID: 37158962] (Human)
• Pan X, Pang M, Ma A, Wang K, Zhang Z, Zhong Q, Yang S Association of TRAIL and Its Receptors with Large-Artery Atherosclerotic Stroke. PLoS ONE, 2015-09-03;10(9):e0136414. 2015-09-03 [PMID: 26334877] (Human)
• Kis-Toth K, Tsokos G Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival. J Immunol, 2014-03-26;192(9):4436-42. 2014-03-26 [PMID: 24670806] (Human)
• Benedict W, Fisher M, Zhang X, Yang Z, Munsell M, Dinney C Use of monitoring levels of soluble forms of cytokeratin 18 in the urine of patients with superficial bladder cancer following intravesical Ad-IFNalpha/Syn3 treatment in a phase l study. Cancer Gene Ther, 2014-02-07;21(3):91-4. 2014-02-07 [PMID: 24503570] (Human)
• Kang S, Park EJ, Joe Y, Seo E, Park MK, Seo SY, Chung HY, Yoo YH, Kim DK, Lee HJ Systemic delivery of TNF-related apoptosis-inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prevents type 1 diabetes in nonobese diabetic mice. Endocrinology, 2010-11-03;151(12):5638-46. 2010-11-03 [PMID: 21047948] (Mouse)
• Vermijlen D, Ellis P, Langford C, Klein A, Engel R, Willimann K, Jomaa H, Hayday AC, Eberl M Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. J. Immunol., 2007-04-01;178(7):4304-14. 2007-04-01 [PMID: 17371987] (Human)
• Liu JM, Zhu Y, Xu ZW, Ouyang WM, Wang JP, Liu XS, Cao YX, Li Q, Fang L, Zhuang R, Yang AG, Jin BQ Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome. Clin. Immunol., 2006-04-17;119(3):245-51. 2006-04-17 [PMID: 16616877] (Human)

FAQs for TRAIL/TNFSF10 (DY375). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: TNFSF10