Human Thrombomodulin/BDCA-3 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Thrombomodulin/BDCA-3 Quantikine ELISA Kit Summary

Background
The Quantikine Human Thrombomodulin Immunoassay is a 4.5 hour solid phase ELISA designed to measure human Thrombomodulin in cell culture supernates, cell lysates, serum, plasma, and urine. It contains NS0-expressed recombinant human Thrombomodulin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Thrombomodulin showed linear curves that ...were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Thrombomodulin.
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Specificity
Natural and recombinant human Thrombomodulin. This kit also recognizes Thrombomodulin complexed with Thrombin, Protein C, and Thrombin/Protein C.
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
THBD

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DTHBD0.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Thrombomodulin/BDCA-3 Quantikine ELISA Kit

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

Thrombomodulin (TM), also known as CD141 and BDCA3, is a transmembrane expressed on vascular endothelial cells (EC), arterial smooth muscle cells, monocytes, and macrophages. It binds Thrombin and enhances the Thrombin-mediated activation of the anti-coagulant Protein C and the anti-fibrinolytic TAFI/Carboxypeptidase B2. Thrombomodulin also inhibits the ability of Thrombin to activate several pro-coagulant proteins (e.g. Fibrinogen, Factor V, Factor XIII, PAR-1). Thrombomodulin exerts multiple anti-inflammatory effects and reduces the severity of disease involving chronic inflammation. In cancer, Thrombomodulin suppresses tumor angiogenesis, growth, and epithelial-mesenchymal transition. Soluble fragments of Thrombomodulin are elevated in the serum, urine, and synovial fluid during coagulation disorders, inflammation, and organ failure.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Thrombomodulin/BDCA-3 (DTHBD0)(11)

We have publications tested in 2 confirmed species: Human, Mouse.


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Human
(10)
Mouse
(1)
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Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using DTHBD0 Applications Species
R Gualtierot, F Tafuri, R Rossio, M Rota, P Bucciarell, B Ferrari, A Giachi, C Suffritti, M Cugno, F Peyvandi, On Behalf Lung Ultrasound Findings and Endothelial Perturbation in a COVID-19 Low-Intensity Care Unit Journal of Clinical Medicine, 2022;11(18):. 2022 [PMID: 36143072] (Human) Human
VE Fiestas So, NR da Costa F, CF Dos Santos, G Corrêa, MDC Cipitelli, M Dornelas R, LJ de Souza, PV Damasco, RV da Cunha, FB Dos Santos, LM de Oliveir, EL de Azeredo Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus Viruses, 2021;13(9):. 2021 [PMID: 34578370] (Human) Human
SA El-Benhawy, NA Sadek, MM Kamel, AM Sharaf, IG Abderhman, MI Morsi, A Abobakr Study the relationship of endothelial damage / dysfunction due to occupational exposure to low dose ionizing radiation versus high dose exposure during radiotherapy Cancer Treat Res Commun, 2020;25(0):100215. 2020 [PMID: 33091734] (Human) Human
SP Polster, A Sharma, C Tanes, AT Tang, P Mericko, Y Cao, J Carrión-Pe, R Girard, J Koskimäki, D Zhang, A Stadnik, SG Romanos, SB Lyne, R Shenkar, K Yan, C Lee, A Akers, L Morrison, M Robinson, A Zafar, K Bittinger, H Kim, JA Gilbert, ML Kahn, L Shen, IA Awad Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma Nat Commun, 2020;11(1):2659. 2020 [PMID: 32461638] (Human) Human
K Hoshino, Y Nakamura, T Nakano, A Watanabe, H Sheng, K Tachibana, H Ishikura Enhanced effect of recombinant human soluble thrombomodulin by ultrasound irradiation in acute liver failure Sci Rep, 2020;10(1):1742. 2020 [PMID: 32015385] (Mouse) Mouse
L Garabet, CE Henriksson, ML Lozano, W Ghanima, J Bussel, E Brodin, MP Fernández-, C Martínez, R González-C, MC Mowinckel, PM Sandset Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin receptor agonists Thromb. Res., 2019;185(0):119-124. 2019 [PMID: 31805421] (Human) Human
FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk, Systemic Inflammation Precedes Microalbuminuria in Diabetes Kidney Int Rep, 2019;4(10):1373-1386. 2019 [PMID: 31701047] (Human) Human
S Kazune, A Caica, K Volceka, O Suba, U Rubins, A Grabovskis Relationship of mottling score, skin microcirculatory perfusion indices and biomarkers of endothelial dysfunction in patients with septic shock: an observational study Crit Care, 2019;23(1):311. 2019 [PMID: 31511042] (Human) Human
KS Rana, C Pararasa, I Afzal, DA Nagel, EJ Hill, CJ Bailey, HR Griffiths, I Kyrou, HS Randeva, S Bellary, JE Brown Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels Cardiovasc Diabetol, 2017;16(1):147. 2017 [PMID: 29121940] (Human) Human
S Béland, P Vallin, O Désy, E Lévesque, SA De Serres Effects of Alloantibodies to Human Leukocyte Antigen on Endothelial Expression and Serum Levels of Thrombomodulin J. Thromb. Haemost, 2017;0(0):. 2017 [PMID: 28239987] (Human) Human
Show All 11 Publications.

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Blogs on Thrombomodulin/BDCA-3.

Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.

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Bioinformatics

Gene Symbol THBD