Human Thrombomodulin/BDCA-3 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Thrombomodulin/BDCA-3 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: THBD

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Thrombomodulin/BDCA-3 DuoSet ELISA, 15 Plate

• BDCA3
• BDCA-3
• CD141 antigen
• CD141
• Fetomodulin
• THBD
• THRM
• Thrombomodulin
• TM

Background

Thrombomodulin (TM), also known as CD141 and BDCA3, is a transmembrane expressed on vascular endothelial cells (EC), arterial smooth muscle cells, monocytes, and macrophages. It binds Thrombin and enhances the Thrombin-mediated activation of the anti-coagulant Protein C and the anti-fibrinolytic TAFI/Carboxypeptidase B2. Thrombomodulin also inhibits the ability of Thrombin to activate several pro-coagulant proteins (e.g. Fibrinogen, Factor V, Factor XIII, PAR-1). Thrombomodulin exerts multiple anti-inflammatory effects and reduces the severity of disease involving chronic inflammation. In cancer, Thrombomodulin suppresses tumor angiogenesis, growth, and epithelial-mesenchymal transition. Soluble fragments of Thrombomodulin are elevated in the serum, urine, and synovial fluid during coagulation disorders, inflammation, and organ failure.

Publications for Thrombomodulin/BDCA-3 (DY3947)(8)

Publications using DY3947

• J Budzianows, J Hiczkiewic, K ?ojewska, E Kawka, R Rutkowski, K Korybalska Predictors of Early-Recurrence Atrial Fibrillation after Catheter Ablation in Women and Men with Abnormal Body Weight Journal of Clinical Medicine, 2021-06-18;10(12):. 2021-06-18 [PMID: 34207297] (Human)
• V Chaban, ER Nakstad, H Stær-Jense, C Schjalm, I Seljeflot, J Vaage, C Lundqvist, JŠ Benth, K Sunde, TE Mollnes, GØ Andersen, SE Pischke Complement activation is associated with poor outcome after out-of-hospital cardiac arrest Resuscitation, 2021-06-11;0(0):. 2021-06-11 [PMID: 34126135] (Human)
• MP Ward, FA Saadeh, SA O'Toole, JJ O'Leary, N Gleeson, LA Norris Procoagulant activity in high grade serous ovarian cancer patients following neoadjuvant chemotherapy-The role of the activated protein C pathway Thrombosis Research, 2021-01-26;200(0):91-98. 2021-01-26 [PMID: 33571724] (Human)
• K Lashkari, GC Teague, U Beattie, J Betts, S Kumar, MM McLaughlin, FJ López Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration PLoS ONE, 2020-08-07;15(8):e0236283. 2020-08-07 [PMID: 32764794] (Human)
• A Merz, U Germing, G Kobbe, J Kaivers, A Jauch, A Radujkovic, M Hummel, A Benner, M Merz, P Dreger, T Luft EASIX for prediction of survival in lower-risk myelodysplastic syndromes Blood Cancer J, 2019-11-11;9(11):85. 2019-11-11 [PMID: 31712595] (Human)
• A Radujkovic, H Dai, L Kordelas, D Beelen, SP Rachakonda, C Müller-Tid, R Kumar, P Dreger, T Luft Asymmetric dimethylarginine serum levels are associated with early mortality after allogeneic stem cell transplantation Haematologica, 2018-12-04;0(0):. 2018-12-04 [PMID: 30514796] (Human)
• G Aguilar-Ma, B Pesch, ES Calderón-A, K Burek, C Jiménez-Ra, CA Juárez-Pér, MD Ochoa-Vázq, L Torre-Bous, LC Acosta-Saa, I Sada-Ovall, J García-Fig, I Alvarado-C, P Castillo-G, AR Báez-Salda, JR Pérez-Padi, J Osnaya-Juá, RM Rivera-Ros, EM García-Baz, YL Bautista-A, E Lazcano-He, DA Munguía-Ca, LM Argote-Gre, D Taeger, DG Weber, S Casjens, I Raiko, T Brüning, G Johnen Biomarkers for Predicting Malignant Pleural Mesothelioma in a Mexican Population Int J Med Sci, 2018-06-04;15(9):883-891. 2018-06-04 [PMID: 30008600] (Human)
• Martin F, McLoughlin A, Rochfort K, Davenport C, Murphy R, Cummins P Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain. PLoS ONE, 2014-09-19;9(9):e108254. 2014-09-19 [PMID: 25238231] (Human)

FAQs for Thrombomodulin/BDCA-3 (DY3947). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: THBD