Human TGF-beta 1 DuoSet ELISA, 15 Plate

Images

 

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human TGF-beta 1 DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
TGFB1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY240.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TGF-beta 1 DuoSet ELISA, 15 Plate

  • CEDLAP
  • DPD1
  • latency-associated peptide
  • TGF beta
  • TGF beta1
  • TGFB
  • TGFB1
  • TGF-beta 1 protein
  • TGFbeta 1
  • TGF-beta 1
  • TGFbeta
  • TGF-beta-1
  • transforming growth factor beta-1
  • transforming growth factor, beta 1

Background

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

Customers Who Viewed This Item Also Viewed...

M6000B
Species: Mu
Applications: ELISA
DY417
Species: Mu
Applications: ELISA
AF3797
Species: Hu, Mu
Applications: ChIP, ICC, IHC, Simple Western, WB
NB100-56479
Species: Bv, Ca, Hu, Mu, Po, Pm, Rt
Applications: ICC/IF, IHC,  IHC-P, Simple Western, WB
DVE00
Species: Hu
Applications: ELISA
NBP1-91258
Species: Bv, Ca, Eq, Fe, Hu, Mu, Po, Rt
Applications: ICC/IF, IHC, IHC-Fr,  IHC-P, Simple Western, WB
233-FB
Species: Hu
Applications: BA
NBP1-82847
Species: Hu
Applications: ICC/IF, IHC,  IHC-P, WB
AF3025
Species: Hu
Applications: ELISA, ICC, WB
236-EG
Species: Hu
Applications: BA
AF2097
Species: Hu
Applications: ChIP, ICC, WB
7754-BH/CF
Species: Hu
Applications: BA
AF1230
Species: Hu, Mu, Rt
Applications: IHC, KO, WB
6507-IL/CF
Species: Hu
Applications: BA
MAB2029
Species: Hu, Mu, Rt
Applications: IHC, Simple Western, WB
DY240
Species: Hu
Applications: ELISA

Publications for TGF-beta 1 (DY240)(204)

We have publications tested in 11 confirmed species: Human, Mouse, Rat, Bovine, Canine, Equine, Feline, Guinea Pig, N/A, Rabbit, Xenograft.


Filter By Application
All Applications
Filter By Species
Human
(180)
Mouse
(7)
Rat
(2)
Bovine
(3)
Canine
(1)
Equine
(3)
Feline
(1)
Guinea Pig
(2)
N/A
(2)
Rabbit
(2)
Xenograft
(1)
All Species
Showing Publications 1 - 10 of 204. Show All 204 Publications.
Publications using DY240 Applications Species
Ye, JL;Grieger, K;Lu, D;Brandenberger, C;Juchem, M;Jordan, M;Oehlsen, L;Zardo, P;Werlein, C;Hesse, C;Sewald, K;Tretbar, S;Thum, T;Chatterjee, S;Bär, C; Telomerase modRNA Offers a Novel RNA-Based Approach to Treat Human Pulmonary Fibrosis Aging cell 2025-09-20 [PMID: 40974335] (Human) Human
Umar, S;Chang, HT;Maienschein-Cline, M;Ravindran, S; Modulation of IRAK4 as a Therapeutic Strategy Against Monosodium Urate- and Xanthine-Induced Inflammation in Macrophages and HepG2 Cells Research square 2025-07-16 [PMID: 40709261] (Human) Human
Timmer, KB;Killian, ML;Harley, BAC; Mesenchymal stem cell activity across a graded scaffold-hydrogel composite biomaterial for tendon-to-bone enthesis repair Bioactive materials 2025-11-01 [PMID: 40703334] (Human) Human
Min, S;Than, N;Shin, YC;Ertugral, EG;Kothapalli, CR;Awoniyi, O;Kim, HJ; Mechanostimulatory cues determine intestinal fibroblast fate and profibrotic remodeling in a physiodynamic human gut-on-a-chip bioRxiv : the preprint server for biology 2025-06-11 [PMID: 40661399] (Human) Human
Hwang, JH;Park, SY;Kang, JH;Jung, HJ;Park, J;Maeng, HJ;Choi, MK;Song, HS;Song, IS;Oh, SH; Compound K-enriched Korean red ginseng prevents lung cancer progression by targeting cancer cells and fibroblasts Journal of ginseng research 2025-07-01 [PMID: 40621073] (Human) Human
Braicu, C;Ciocan, C;Bica, C;Zanoaga, O;Pop, LA;Strilciuc, S;Staicu, A;Goidescu, I;Muresan, D;Surcel, M;Berindan-Neagoe, I; Altered miRNA Signatures in Follicular Fluid: Insights into Infertility Etiologies Genes 2025-04-30 [PMID: 40428359] (Human) Human
Belboul, A;Ashworth, J;Fadel, A;Mcloughlin, J;Mahmoud, A;El Mohtadi, M; Estrogen induces the alternative activation of macrophages through binding to estrogen receptor-alpha Experimental and molecular pathology 2025-05-20 [PMID: 40398084] (Human) Human
Lokau, J;Bollmann, M;Garbers, Y;Feist, E;Lohmann, CH;Bertrand, J;Garbers, C; Transforming growth factor beta induces interleukin-11 expression in osteoarthritis Cytokine 2025-01-28 [PMID: 39879889] (Human) Human
Chai, N;Stachon, T;Häcker, S;Berger, T;Li, Z;Amini, M;Suiwal, S;Seitz, B;Langenbucher, A;Szentmáry, N; The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathways PloS one 2025-01-27 [PMID: 39869570] (Human) Human
Loos, B;Salas-Bastos, A;Nordin, A;Debbache, J;Stierli, S;Cheng, PF;Rufli, S;Wyss, C;Levesque, MP;Dummer, R;Wong, WW;Pascolo, S;Cantù, C;Sommer, L; TGF? signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis Cell death & disease 2024-12-21 [PMID: 39709491] (Human) Human
Show All 204 Publications.

Reviews for TGF-beta 1 (DY240) (0)

There are no reviews for TGF-beta 1 (DY240). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for TGF-beta 1 (DY240). (Showing 1 - 1 of 1 FAQs).

  1. What is the difference between the Quantikine and Duoset ELISA kits?
    • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Additional TGF-beta 1 Products

Blogs on TGF-beta 1.

TGF-beta 1 - a versatile signaling molecule with roles in development and disease
The transforming growth factor-beta (TGF-beta) family consists of a wide variety of signaling proteins with roles in development. TGF-beta signaling controls growth, differentiation, and immune responses and is often misregulated in cancer. TGF-beta ...  Read full blog post.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Review this Product

Be the first to review our Human TGF-beta 1 DuoSet ELISA, 15 Plate and receive a gift card or discount.

Bioinformatics

Gene Symbol TGFB1