Human sTNF RI/TNFRSF1A DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human sTNF RI/TNFRSF1A DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFRSF1A

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human sTNF RI/TNFRSF1A DuoSet ELISA, 15 Plate

• CD120a antigen
• CD120a
• FPF
• p55
• p55-R
• p60
• TNF RI
• TNFARMGC19588
• TNF-R
• TNF-R1
• TNFR1TBP1
• TNFR55
• TNF-R55
• TNFR60
• TNFRI
• TNF-RI
• TNF-R-I
• TNFR-I
• TNFRSF1A
• tumor necrosis factor binding protein 1
• Tumor necrosis factor receptor 1
• tumor necrosis factor receptor 1A isoform beta
• tumor necrosis factor receptor superfamily member 1A
• tumor necrosis factor receptor superfamily, member 1A
• tumor necrosis factor receptor type 1
• Tumor necrosis factor receptor type I
• tumor necrosis factor-alpha receptor

Background

TNF RI (TNF receptor 1; TNF R-p55/p60) is a transmembrane receptor for TNF-alpha and Lymphotoxin-alpha/TNF-beta. A soluble decoy form of the receptor is shed by ADAM-17/TACE in response to inflammatory stimulation. TNF RI signaling through NFkB is essential for the development of lymph node germinal centers and Peyer’s patches and for combating intracellular pathogens such as Listeria.

Publications for TNF RI/TNFRSF1A (DY225)(36)

Publications using DY225

• da Costa Teixeira, LA;Soares, LA;Lima, LP;Avelar, NCP;de Moura, JA;Leopoldino, AAO;Figueiredo, PHS;Parentoni, AN;Mendonça, VA;Lacerda, ACR; Cognitive function is associated with performance in time up and go test and with leptin blood levels in community-dwelling older women Scientific reports 2024-04-29 [PMID: 38684691] (Human)
• Augusto da Costa Teixeira, L;Rocha-Vieira, E;Aparecida Soares, L;Mota de Oliveira, F;Aparecida Oliveira Leopoldino, A;Netto Parentoni, A;Amaral Mendonça, V;Cristina Rodrigues Lacerda, A; The strong inverse association between plasma concentrations of soluble tumor necrosis factor receptors type 1 with adiponectin/leptin ratio in older women Cytokine 2024-01-27 [PMID: 38281360] (Human)
• Viegas, ÂA;Santos, T;Nobre, JNP;Santos, JMD;Silva Lage, VKD;Fernandes, AC;Peixoto, MFD;Morais, RLS;Sartorio, A;Mendonça, VA;Lacerda, ACR; Association between biomarkers of redox status and cytokines with different patterns of habitual physical activity in eutrophic and overweight/obese preschoolers: multivariate analysis of a cross-sectional study BMC public health 2023-11-28 [PMID: 38017390] (Human)
• Arthanarisami, A;Komaru, Y;Katsouridi, C;Schumacher, J;Verges, DK;Ning, L;Abdelmageed, MM;Herrlich, A;Kefaloyianni, E; Acute Kidney Injury-Induced Circulating TNFR1/2 Elevations Correlate with Persistent Kidney Injury and Progression to Fibrosis Cells 2023-09-05 [PMID: 37759437] (Human)
• da Costa Teixeira, LA;Avelar, NCP;Peixoto, MFD;Parentoni, AN;Santos, JMD;Pereira, FSM;Danielewicz, AL;Leopoldino, AAO;Costa, SP;Arrieiro, AN;Soares, LA;da Silva Lage, VK;Prates, ACN;Taiar, R;de Carvalho Bastone, A;Oliveira, VC;Oliveira, MX;Costa, HS;Nobre, JNP;Brant, FP;Duarte, TC;Figueiredo, PHS;Mendonça, VA;Lacerda, ACR; Inflammatory biomarkers at different stages of Sarcopenia in older women Scientific reports 2023-06-26 [PMID: 37365209] (Human)
• LAC Teixeira, JM Dos Santos, AN Parentoni, LP Lima, TC Duarte, FP Brant, CDC Neves, FSM Pereira, NCP Avelar, AL Danielewic, AAO Leopoldino, SP Costa, AN Arrieiro, LA Soares, ACN Prates, JNP Nobre, A de Carvalh, VC de Oliveir, MX Oliveira, PH Scheidt Fi, HS Costa, V Amaral Men, R Taiar, AC Rodrigues Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study Journal of Clinical Medicine, 2022-12-02;11(23):. 2022-12-02 [PMID: 36498747] (Human)
• T Baram, N Oren, N Erlichman, T Meshel, A Ben-Baruch Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFalpha Receptors in Human Triple-Negative Breast Cancer Cancers, 2022-07-19;14(14):. 2022-07-19 [PMID: 35884574] (Human)
• ICS Dias, SM de Campos-, ELM Vieira, APL Mota, PS Azevedo, VTDS Anício, FC Guimarães, LM Mantovani, BF Cruz, AL Teixeira, JV Salgado Adiponectin and Stnfr2 peripheral levels are associated with cardiovascular risk in patients with schizophrenia Journal of psychiatric research, 2021-11-09;0(0):. 2021-11-09 [PMID: 34785039] (Human)
• E Sancho Fer, K Hanslin, M Hultström, A Larsson, R Frithiof, M Lipcsey, Uppsala In Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study Cytokine, 2021-10-05;149(0):155727. 2021-10-05 [PMID: 34628127] (Human)
• Y Palacios, A Ruiz, LA Ramón-Luin, R Ocaña-Guzm, O Barreto-Ro, A Sánchez-Mo, B Tecuatzi-C, AG Regalado-G, RD Pineda-Gud, A García-Mar, F Juárez-Her, JP Farias-Con, I Fricke-Gal, G Pérez-Rubi, R Falfán-Val, I Buendia-Ro, K Medina-Que, L Chavez-Gal Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, with a Relationship to Mortality International Journal of Molecular Sciences, 2021-08-05;22(16):. 2021-08-05 [PMID: 34445140] (Human)
• CDC Neves, VKS Lage, LP Lima, MA Matos, ÉLM Vieira, AL Teixeira, PHS Figueiredo, HS Costa, ACR Lacerda, VA Mendonça Inflammatory and oxidative biomarkers as determinants of functional capacity in patients with COPD assessed by 6-min walk test-derived outcomes Experimental gerontology, 2021-06-21;152(0):111456. 2021-06-21 [PMID: 34166733] (Human)
• HK Pihlstrøm, T Ueland, AE Michelsen, P Aukrust, F Gatti, C Hammarströ, M Kasprzycka, J Wang, G Haraldsen, G Mjøen, DO Dahle, K Midtvedt, IA Eide, A Hartmann, H Holdaas Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients PLoS ONE, 2020-12-16;15(12):e0243759. 2020-12-16 [PMID: 33326471] (Human)
• M Bergquist, L Samuelsson, A Larsson, J Tydén, J Johansson, M Lipcsey TNFR1, TNFR2, neutrophil gelatinase-associated lipocalin and heparin binding protein in identifying sepsis and predicting outcome in an intensive care cohort Scientific Reports, 2020-09-18;10(1):15350. 2020-09-18 [PMID: 32948801] (Human)
• IG Barbosa, RA Ferreira, NP Rocha, GC Mol, F da Mata Ch, IE Bauer, AL Teixeira Predictors of cognitive performance in bipolar disorder: The role of educational degree and inflammatory markers J Psychiatr Res, 2018-09-17;106(0):31-37. 2018-09-17 [PMID: 30261412] (Human)
• PHS Figueiredo, MMO Lima, HS Costa, JB Martins, OD Flecha, PF Gonçalves, FL Alves, VGB Rodrigues, EHB Maciel, VA Mendonça, ACR Lacerda, ÉLM Vieira, AL Teixeira, F de Paula, CH Balthazar Effects of the inspiratory muscle training and aerobic training on respiratory and functional parameters, inflammatory biomarkers, redox status and quality of life in hemodialysis patients: A randomized clinical trial PLoS ONE, 2018-07-26;13(7):e0200727. 2018-07-26 [PMID: 30048473] (Human)
• J Panezai, A Ghaffar, M Altamash, PE Engström, A Larsson Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis PLoS ONE, 2018-06-11;13(6):e0197235. 2018-06-11 [PMID: 29889832] (Human)
• C Dürr, BS Hanna, A Schulz, F Lucas, M Zucknick, A Benner, A Clear, S Ohl, S Öztürk, T Zenz, S Stilgenbau, M Li-Weber, PH Krammer, JG Gribben, P Lichter, M Seiffert TNF receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin Haematologica, 2018-01-11;0(0):. 2018-01-11 [PMID: 29326123] (Human)
• MM White, P Geraghty, E Hayes, S Cox, W Leitch, B Alfawaz, GM Lavelle, OJ McElvaney, R Flannery, J Keenan, P Meleady, M Henry, M Clynes, C Gunaratnam, NG McElvaney, EP Reeves Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease EBioMedicine, 2017-08-16;23(0):173-184. 2017-08-16 [PMID: 28835336] (Human)
• Neuroendocrine Inflammatory Responses in Overweight/Obese Infants PLoS ONE, 2016-12-01;11(12):e0167593. 2016-12-01 [PMID: 27907172] (Human)
• ADAM17 substrate release in proximal tubule drives kidney fibrosis JCI Insight, 2016-08-18;1(13):. 2016-08-18 [PMID: 27642633] (Human)
• Frampton , John P, White , Joshua B, Simon , Arlyne B, Tsuei , Michael, Paczesny , Sophie, Takayama , Shuichi Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA. Sci Rep, 2014-05-02;4(0):4878. 2014-05-02 [PMID: 24786974] (Human)
• Yin F, Battiwalla M, Ito S, Feng X, Chinian F, Melenhorst J, Koklanaris E, Sabatino M, Stroncek D, Samsel L, Klotz J, Hensel N, Robey P, Barrett A Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses. Stem Cells, 2014-05-01;32(5):1278-88. 2014-05-01 [PMID: 24452962] (Human)
• Wium C, Aasheim E, Ueland T, Michelsen A, Thorsby P, Larsen I, Torjesen P, Aukrust P, Birkeland K Differences in insulin sensitivity, lipid metabolism and inflammation between young adult Pakistani and Norwegian patients with type 2 diabetes: a cross sectional study. BMC Endocr Disord, 2013-10-22;13(0):49. 2013-10-22 [PMID: 24148878] (Human)
• Moh M, Lorenzini P, Gullo C, Schwarz H Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB J, 2013-04-25;27(8):2957-66. 2013-04-25 [PMID: 23620528] (Human)
• Breshears L, Schlievert P, Peterson M A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). J Biol Chem, 2012-07-25;287(39):32578-87. 2012-07-25 [PMID: 22833676] (Human)
• Richards FM, Tape CJ, Jodrell DI, Murphy G Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo. PLoS ONE, 2012-07-11;7(7):e40597. 2012-07-11 [PMID: 22792380] (Human)
• Neuenschwander LC, Bittencourt H, Ribeiro AF, Teixeira AL, Teixeira MM, Teixeira JC, Nobre V Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients. Clinics (Sao Paulo), 2011-01-01;66(10):1699-705. 2011-01-01 [PMID: 22012040] (Human)
• Eagan TM, Ueland T, Wagner PD, Hardie JA, Mollnes TE, Damas JK, Aukrust P, Bakke PS Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. Eur. Respir. J., 2009-07-30;35(3):540-8. 2009-07-30 [PMID: 19643942] (Human)
• Touchard E, Bloquel C, Bigey P, Kowalczuc L, Jonet L, Thillaye-Goldenberg B, Naud MC, Scherman D, de Kozak Y, Benezra D, Behar-Cohen F Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis. Gene Ther., 2009-05-14;16(7):862-73. 2009-05-14 [PMID: 19440225] (Human)
• Li X, Magenheimer BS, Xia S, Johnson T, Wallace DP, Calvet JP, Li R A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat. Med., 2008-06-15;14(8):863-8. 2008-06-15 [PMID: 18552856] (Human)
• Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases. Med Eng Phys, 2008-03-03;30(8):976-83. 2008-03-03 [PMID: 18313970] (Human)
• van Mierlo GJ, Scherer HU, Hameetman M, Morgan ME, Flierman R, Huizinga TW, Toes RE Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J. Immunol., 2008-03-01;180(5):2747-51. 2008-03-01 [PMID: 18292492] (Human)
• Mattey DL, Glossop JR, Nixon NB, Dawes PT Circulating levels of tumor necrosis factor receptors are highly predictive of mortality in patients with rheumatoid arthritis. Arthritis Rheum., 2007-12-01;56(12):3940-8. 2007-12-01 [PMID: 18050238] (Human)
• Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, Mackay M, Aranow C, Putterman C, Mohan C Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J. Immunol., 2007-11-15;179(10):7166-75. 2007-11-15 [PMID: 17982109] (Human)
• Kallio R, Sequeiros R, Surcel HM, Ohtonen P, Kiviniemi H, Syrjala H Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors. Cytokine, 2006-07-25;34(5):278-83. 2006-07-25 [PMID: 16870467] (Human)
• Glossop JR, Dawes PT, Nixon NB, Mattey DL Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis. Arthritis Res. Ther., 2005-09-07;7(6):R1227-34. 2005-09-07 [PMID: 16277675] (Human)

FAQs for TNF RI/TNFRSF1A (DY225). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: TNFRSF1A