Human Serpin E1/PAI-1 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human Serpin E1/PAI-1 Quantikine ELISA Kit Summary

Background
The Quantikine Human Serpin E1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Serpin E1 in cell culture supernates, cell lysates, and plasma. It contains Sf 21-expressed recombinant human Serpin E1 and has been shown to accurately quantitate the recombinant factor in its active and latent forms as well as in the vitronectin complexes. However, the kit does not... detect recombinant human Serpin E1 in complexes with recombinant human uPA and recombinant human tPA. Results obtained using natural human Serpin E1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Serpin E1.
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Specificity
Natural and recombinant human Serpin E1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
SERPINE1

Applications/Dilutions

Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DSE100.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Serpin E1/PAI-1 Quantikine ELISA Kit

  • Endothelial plasminogen activator inhibitor
  • Nexin
  • PAI1
  • PAI-1
  • PAI1PAI-1
  • PAISerpin E1
  • PLANH1
  • PLANH1plasminogen activator inhibitor 1
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1
  • Serpin E1
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1

Background

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Serpin E1/PAI-1 (DSE100)(30)

We have publications tested in 1 confirmed species: Human.


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Human
(30)
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Showing Publications 1 - 10 of 30. Show All 30 Publications.
Publications using DSE100 Applications Species
C Voukalis, GYH Lip, E Shantsila Effects of antithrombotic drugs on the prothrombotic state in patients with atrial fibrillation: The west Birmingham atrial fibrillation project Thrombosis Research, 2021;200(0):149-155. 2021 [PMID: 33610887] (Human) Human
L Peng, Y Ye, H Mullikin, L Lin, C Kuhn, M Rahmeh, S Mahner, U Jeschke, V von Schönf Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines J Reprod Immunol, 2020;142(0):103210. 2020 [PMID: 33011635] (Human) Human
Y Ye, C Kuhn, M Kösters, GJ Arnold, H Ishikawa-A, C Schulz, N Rogenhofer, CJ Thaler, S Mahner, T Fröhlich, U Jeschke, V von Schönf Anti ?-enolase antibody is a novel autoimmune biomarker for unexplained recurrent miscarriages EBioMedicine, 2019;0(0):. 2019 [PMID: 30827932] (Human) Human
JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, SK Hashmi, L Prata, MM Masternak, SB Kritchevsk, N Musi, JL Kirkland Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study EBioMedicine, 2019;0(0):. 2019 [PMID: 30616998] (Human) Human
Y Ye, A Vattai, N Ditsch, C Kuhn, M Rahmeh, S Mahner, M Ripphahn, R Immler, M Sperandio, U Jeschke, V von Schoen Prostaglandin E2 receptor 3 (EP3) signaling is induced in placentas with unexplained recurrent pregnancy losses (uRPL) Endocr Connect, 2018;0(0):. 2018 [PMID: 29700097] (Human) Human
M Jakubowski, J D?bski, E Szahidewic, A Turek-Jaku, J Gawry?, K Gawry?, R Skomro, A Derkacz, A Doroszko Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance Oxid Med Cell Longev, 2017;2017(0):3132063. 2017 [PMID: 29090039] (Human) Human
S Chen, H Jiang, Y Liu, Z Hou, Y Yue, Y Zhang, F Zhao, Z Xu, Y Li, X Mou, L Li, T Wang, J Zhao, C Han, Y Sui, M Wang, Z Yang, Y Lu, Y Zhu, J Li, X Shen, F Sun, Q Chen, H Chen, Y Yuan Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders Sci Rep, 2017;7(1):6871. 2017 [PMID: 28761093] (Human) Human
Plasminogen Activator Inhibitor-1 in depression: Results from Animal and Clinical Studies Sci Rep, 2016;6(0):30464. 2016 [PMID: 27456456] (Human) Human
Rolandsson Enes S, Andersson Sjoland A, Skog I, Hansson L, Larsson H, Le Blanc K, Eriksson L, Bjermer L, Scheding S, Westergren-Thorsson G MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC. Sci Rep, 0;6(0):29160. 0 [PMID: 27381039] (Human) Human
MAP3K19 Is a Novel Regulator of TGF-? Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis PLoS ONE, 2016;11(5):e0154874. 2016 [PMID: 27144281] (Human) Human
Show All 30 Publications.

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Product General Protocols

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FAQs for Serpin E1/PAI-1 (DSE100). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DSE100
HRP PDSE100
HRP SSE100

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Bioinformatics

Gene Symbol SERPINE1