Human Serpin E1/PAI-1 Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Catalog# & Conjugate Size Price

Human Serpin E1/PAI-1 Quantikine ELISA Kit Summary

Background
The Quantikine Human Serpin E1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Serpin E1 in cell culture supernates, cell lysates, and plasma. It contains Sf 21-expressed recombinant human Serpin E1 and has been shown to accurately quantitate the recombinant factor in its active and latent forms as well as in the vitronectin complexes. However, the kit does not... detect recombinant human Serpin E1 in complexes with recombinant human uPA and recombinant human tPA. Results obtained using natural human Serpin E1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Serpin E1.
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Specificity
Natural and recombinant human Serpin E1
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
SERPINE1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
Interference observed with 1 or more available related molecules.
Publications
Read Publications using DSE100.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Serpin E1/PAI-1 Quantikine ELISA Kit

  • Endothelial plasminogen activator inhibitor
  • Nexin
  • PAI1
  • PAI-1
  • PAI1PAI-1
  • PAISerpin E1
  • PLANH1
  • PLANH1plasminogen activator inhibitor 1
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1
  • Serpin E1
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1

Background

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Serpin E1/PAI-1 (DSE100)(38)

We have publications tested in 1 confirmed species: Human.


Filter By Application
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Human
(38)
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Showing Publications 1 - 10 of 38. Show All 38 Publications.
Publications using DSE100 Applications Species
KD Wick, L Siegel, JD Neaton, C Oldmixon, J Lundgren, RL Dewar, HC Lane, BT Thompson, MA Matthay, ACTIV-3/TI RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19 JCI Insight, 2022;7(9):. 2022 [PMID: 35298440] (Human) Human
Y Qin, J Zhang, S Babapoor-F, B Applewhite, M Deshpande, H Megarity, M Flores-Bel, S Aparicio-D, T Ma, Y Rui, SY Tzeng, JJ Green, MV Canto-Sole, S Montaner, A Sodhi PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients Science Advances, 2022;8(9):eabm1896. 2022 [PMID: 35235351] (Human) Human
C Cohen, O Le Goff, F Soysouvanh, F Vasseur, M Tanou, C Nguyen, L Amrouche, J Le Guen, O Saltel-Ful, T Meunier, T Nguyen-Kho, M Rabant, D Nochy, C Legendre, G Friedlande, BG Childs, DJ Baker, B Knebelmann, D Anglicheau, F Milliat, F Terzi Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1 Embo Molecular Medicine, 2021;13(11):e14146. 2021 [PMID: 34725920] (Human) Human
M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients Molecular and Cellular Biology, 2021;0(0):MCB0046721. 2021 [PMID: 34723652] (Human) Human
SH Cho, JH Kim, HJ An, YR Kim, EH Ahn, JR Lee, JO Kim, JJ Ko, NK Kim Genetic Polymorphisms in miR-604A>G, miR-938G>A, miR-1302-3C>T and the Risk of Idiopathic Recurrent Pregnancy Loss International Journal of Molecular Sciences, 2021;22(11):. 2021 [PMID: 34200157] (Human) Human
C Voukalis, GYH Lip, E Shantsila Effects of antithrombotic drugs on the prothrombotic state in patients with atrial fibrillation: The west Birmingham atrial fibrillation project Thrombosis Research, 2021;200(0):149-155. 2021 [PMID: 33610887] (Human) Human
YY Wang, HD Chen, S Lo, YK Chen, YC Huang, SC Hu, YC Hsieh, AC Hung, MF Hou, SF Yuan Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages Cancers, 2020;12(12):. 2020 [PMID: 33256011] (Human) Human
L Peng, Y Ye, H Mullikin, L Lin, C Kuhn, M Rahmeh, S Mahner, U Jeschke, V von Schönf Expression of trophoblast derived prostaglandin E2 receptor 2 (EP2) is reduced in patients with recurrent miscarriage and EP2 regulates cell proliferation and expression of inflammatory cytokines J Reprod Immunol, 2020;142(0):103210. 2020 [PMID: 33011635] (Human) Human
K Zmajkovico, Y Bauer, K Menyhart, M Schnoebele, D Freti, M Boucher, B Renault, R Studer, M Birker-Rob, A Klenk, O Nayler, J Gatfield GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFbeta1 PLoS ONE, 2020;15(2):e0228195. 2020 [PMID: 32053631] (Human) Human
N Hao, TT Chiou, CH Wu, YY Lei, PL Liang, MC Chao, H Yang, JB Chen Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients Biomed Res Int, 2019;2019(0):2152584. 2019 [PMID: 31192253] (Human) Human
Show All 38 Publications.

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Bioinformatics

Gene Symbol SERPINE1