Serpin E1/PAI-1 Products

Antibodies
Serpin E1/PAI-1 Antibody (112 ...
Serpin E1/PAI-1 Antibody (1121C) [...
MAB17861
Species: Hu
Applications: WB, Simple Western
Host: Rabbit Monoclonal
Serpin E1/PAI-1 Antibody [Unc ...
Serpin E1/PAI-1 Antibody [Unconjug...
AF1786
Species: Hu
Applications: WB, Simple Western, IHC, IP, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
Serpin E1/PAI-1 Antibody Pair ...
Serpin E1/PAI-1 Antibody Pair
H00005054-PW1
Species: Hu
Applications: WB, IP
Serpin E1/PAI-1 Antibody Pair ...
Serpin E1/PAI-1 Antibody Pair
H00005054-PW2
Species: Hu
Applications: WB, IP
ELISA Kits
Serpin E1/PAI-1 ELISA Kit
Serpin E1/PAI-1 ELISA Kit
NBP1-83740
Species: Hu
Applications: ELISA
Kits
Serpin E1/PAI-1 Assay Kit
Serpin E1/PAI-1 Assay Kit
KA0973
Species: Hu
Applications: Func
Lysates
Serpin E1/PAI-1 Overexpressio ...
Serpin E1/PAI-1 Overexpression Lys...
H00005054-T01
Species: Hu
Applications: WB
Serpin E1/PAI-1 Overexpressio ...
Serpin E1/PAI-1 Overexpression Lys...
NBP2-09008
Applications: WB
Proteins
Serpin E1/PAI-1 Recombinant P ...
Serpin E1/PAI-1 Recombinant Protein
NBC1-18526
Species: Hu
Applications: PAGE
Serpin E1/PAI-1 Recombinant P ...
Serpin E1/PAI-1 Recombinant Protei...
NBP2-13298PEP
Species: Hu
Applications: AC
RNAi
Serpin E1/PAI-1 RNAi
Serpin E1/PAI-1 RNAi
H00005054-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

PAI-1 and PAI-2 (for plasminogen activator inhibitor-1 and -2) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 have been shown to regulate uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage, resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. uPA is a serine proteinase that is a member of the trypsin family. It is responsible for the cleavage of plasminogen at the Arg-Val bond to produce plasmin. uPA consists of two chains designated A and B. The A chain can be cleaved, resulting in low and high molecular mass forms of uPA.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 5054
Alternate Names
  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1
  • PLANH1plasminogen activator inhibitor 1
  • PAI1PAI-1
  • PAISerpin E1
  • Endothelial plasminogen activator inhibitor
  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1

Research Areas for Serpin E1/PAI-1

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Cancer

Bioinformatics Tool for Serpin E1/PAI-1

Discover related pathways, diseases and genes to Serpin E1/PAI-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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