Human PD-L2/B7-DC DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human PD-L2/B7-DC DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PDCD1LG2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human PD-L2/B7-DC DuoSet ELISA, 15 Plate

• B7-DC
• bA574F11.2
• Btdc
• Butyrophilin B7-DC
• Butyrophilin-like Protein
• CD273 antigen
• CD273
• CD273PD-1 ligand 2
• MGC142240
• PD-1-ligand 2
• PDCD1L2MGC142238
• PDCD1LG2
• PDL2
• PD-L2
• PDL2B7DC
• PD-L2PDCD1 ligand 2
• programmed cell death 1 ligand 2
• Programmed death ligand 2

Background

PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.

Publications for PD-L2/B7-DC/PDCD1LG2 (DY1224)(9)

Publications using DY1224

• Wang, CM;Jan Wu, YJ;Zheng, JW;Huang, LY;Tan, KP;Chen, JY; T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity Journal of biomedical science 2024-04-22 [PMID: 38650001] (Human)
• K Krueger, Z Mayer, M Kottmaier, M Gerckens, S Boeck, P Luppa, S Holdenried Robust Preanalytical Performance of Soluble PD-1, PD-L1 and PD-L2 Assessed by Sensitive ELISAs in Blood Biomedicines, 2022-10-11;10(10):. 2022-10-11 [PMID: 36289796] (Human)
• K Krueger, Z Mayer, M Gerckens, S Boeck, P Luppa, S Holdenried High Quality Performance of Novel Immunoassays for the Sensitive Quantification of Soluble PD-1, PD-L1 and PD-L2 in Blood Biomedicines, 2022-09-26;10(10):. 2022-09-26 [PMID: 36289665] (Human)
• L Chavez-Gal, A Ruiz, K Martinez-E, H Aguilar-Du, M Torres, R Falfan-Val, G Pérez-Rubi, M Selman, I Buendia-Ro Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical Ventilation Biomolecules, 2022-03-14;12(3):. 2022-03-14 [PMID: 35327637] (Human)
• Y Tago, C Kobayashi, M Ogura, J Wada, S Yamaguchi, T Yamaguchi, M Hayashi, T Nakaishi, H Kubo, Y Ueda Human amnion-derived mesenchymal stem cells attenuate xenogeneic graft-versus-host disease by preventing T cell activation and proliferation Scientific Reports, 2021-01-28;11(1):2406. 2021-01-28 [PMID: 33510297] (Human)
• AH Ren, I Prassas, A Soosaipill, S Jarvi, S Gallinger, V Kulasingam, EP Diamandis Investigating a novel multiplex proteomics technology for detection of changes in serum protein concentrations that may correlate to tumor burden F1000Research, 2020-07-20;9(0):732. 2020-07-20 [PMID: 33274048] (Human)
• KH Grinnemo, M Löfling, L Nathanson, R Baumgartne, DFJ Ketelhuth, V Beljanski, LC Davies, C Österholm Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells Stem Cell Res Ther, 2019-12-04;10(1):371. 2019-12-04 [PMID: 31801632] (Human)
• KS Schwab, G Kristianse, HH Schild, SEA Held, A Heine, P Brossart Successful Treatment of Refractory Squamous Cell Cancer of the Head and Neck with Nivolumab and Ipilimumab Case Rep Oncol, 2018-01-04;11(1):17-20. 2018-01-04 [PMID: 29515404] (Human)
• Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression Stem Cells, 2016-10-26;0(0):. 2016-10-26 [PMID: 27671847] (Human)

Bioinformatics

• Gene Symbol: PDCD1LG2