Human P-Selectin/CD62P DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human P-Selectin/CD62P DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SELP

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human P-Selectin/CD62P DuoSet ELISA, 15 Plate

• CD62P antigen
• CD62P
• FLJ45155
• GMP140
• GRMP
• PADGEM
• PADGEMantigen CD62)
• PSEL
• P-Selectin
• selectin P (granule membrane protein 140kDa, antigen CD62)
• SELP

Background

The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The human and rat proteins share approximately 67% amino acid sequence identity. The mouse and rat proteins share approximately 78% amino acid sequence identity. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. Human and mouse L-Selectin share 76% amino acid sequence identity. Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is expressed by activated platelets and endothelial cells. The extracellular domains of human and mouse P-Selectin share approximately 73% amino acid sequence identity.

Publications for P-Selectin/CD62P (DY137)(22)

Publications using DY137

• Rezaei, A;Pourfarzam, S;Jamali, T;Mohammadi, NG;Andalib, A;Hassan, ZM;Ayubi, F;Ghazanfari, T; Exploring chemokines and soluble adhesion molecules in mustard lung pathogenesis International immunopharmacology 2025-02-08 [PMID: 39923581] (Human)
• Pesold, VV;Wendler, O;Mueller, SK; Effects of anti-inflammatory drugs on distinct endotypes of chronic rhinosinusitis without nasal polyps: comparison using an ex-vivo model European review for medical and pharmacological sciences 2024-10-01 [PMID: 39497591] (Human)
• Lengvenyte, A;Cognasse, F;Hamzeh-Cognasse, H;Sénèque, M;Strumila, R;Olié, E;Courtet, P; Baseline circulating biomarkers, their changes, and subsequent suicidal ideation and depression severity at 6 months: A prospective analysis in patients with mood disorders Psychoneuroendocrinology 2024-07-06 [PMID: 39003840] (Human)
• Lekva, T;Sundaram, AYF;Roland, MCP;Åsheim, J;Michelsen, AE;Norwitz, ER;Aukrust, P;Gilfillan, GD;Ueland, T; Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia-an exploratory study BMC medicine 2023-11-23 [PMID: 37996819] (Human)
• Tang, Z;Xu, Y;Tan, Y;Shi, H;Jin, P;Li, Y;Teng, J;Liu, H;Pan, H;Hu, Q;Cheng, X;Ye, J;Su, Y;Sun, Y;Meng, J;Zhou, Z;Chi, H;Wang, X;Liu, J;Lu, Y;Liu, F;Dai, J;Yang, C;Chen, S;Liu, T; CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis Nature communications 2023-08-21 [PMID: 37604832] (Human)
• Reis-Goes, FS;Silva, NN;Gondim, TM;Figueiredo, RG;Evangelista, GAO;Marchioro, SB;Costa, RS;Torres, AJL;Meyer, RJ;Trindade, SC;Fortuna, V; Exploring dysregulated immune response genes and endothelial dysfunction biomarkers as predictors of severe COVID-19 International immunopharmacology 2023-07-05 [PMID: 37453154] (Human)
• L Song, X Zhao, R Chen, J Li, J Zhou, C Liu, P Zhou, Y Wang, Y Chen, H Zhao, H Yan Association of PCSK9 with inflammation and platelet activation markers and recurrent cardiovascular risks in STEMI patients undergoing primary PCI with or without diabetes Cardiovascular Diabetology, 2022-05-20;21(1):80. 2022-05-20 [PMID: 35596184] (Human)
• KN Lee, KH Park, YM Kim, I Cho, TE Kim Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid PLoS ONE, 2022-05-10;17(5):e0268291. 2022-05-10 [PMID: 35536791] (Human)
• MH Schutte, R Kleemann, NM Nota, CM Wiepjes, JM Snabel, G T'Sjoen, A Thijs, M den Heijer The effect of transdermal gender-affirming hormone therapy on markers of inflammation and hemostasis PLoS ONE, 2022-03-15;17(3):e0261312. 2022-03-15 [PMID: 35290388] (Human)
• E Fragopoulo, C Argyrou, M Detopoulou, S Tsitsou, S Seremeti, M Yannakouli, S Antonopoul, G Kolovou, P Kalogeropo The effect of moderate wine consumption on cytokine secretion by peripheral blood mononuclear cells: A randomized clinical study in coronary heart disease patients Cytokine, 2021-07-08;146(0):155629. 2021-07-08 [PMID: 34247040] (Human)
• TN Chimponda, C Mushayi, DNM Osakunor, A Vengesai, E Enwono, S Amanfo, J Murray, C Tshuma, F Mutapi, T Mduluza Elevation of C-reactive protein, P-selectin and Resistin as potential inflammatory biomarkers of urogenital Schistosomiasis exposure in preschool children BMC Infect. Dis., 2019-12-19;19(1):1071. 2019-12-19 [PMID: 31856765] (Human)
• I Govorov, K Bremme, A Larsson, M Holmström, E Komlichenk, R Chaireti, M Mints Blood inflammatory and endothelial markers in women with von Willebrand disease PLoS ONE, 2019-01-10;14(1):e0210544. 2019-01-10 [PMID: 30629692] (Human)
• GJ Nieuwenhui, TAJ van den Be, SJL Bakker, MC van den He, MMRF Struys, T Lisman, RA Pol Preemptively and non-preemptively transplanted patients show a comparable hypercoagulable state prior to kidney transplantation compared to living kidney donors PLoS ONE, 2018-07-16;13(7):e0200537. 2018-07-16 [PMID: 30011293] (Human)
• Erdman L, D'Acremont V, Hayford K, Rajwans N, Kilowoko M, Kyungu E, Hongoa P, Alamo L, Streiner D, Genton B, Kain K Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study. PLoS ONE, 2015-09-14;10(9):e0137592. 2015-09-14 [PMID: 26366571] (Human)
• Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A. Am. J. Pathol., 2012-05-31;181(2):693-705. 2012-05-31 [PMID: 22659470] (Human)
• van Bladel ER, Roest M Up-regulation of platelet activation in hemophilia A. Haematologica, 2011-03-21;0(0):. 2011-03-21 [PMID: 21422116] (Human)
• Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study. PLoS ONE, 2011-02-25;6(2):e17440. 2011-02-25 [PMID: 21364762] (Human)
• de Mast Q, de Groot PG, van Heerde WL, Roestenberg M, van Velzen JF, Verbruggen B, Roest M, McCall M, Nieman AE, Westendorp J, Syafruddin D, Fijnheer R, van Dongen-Lases EC, Sauerwein RW, van der Ven AJ Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br. J. Haematol., 2010-10-19;151(5):495-503. 2010-10-19 [PMID: 20955404] (Human)
• Snoep JD, Roest M, Barendrecht AD High platelet reactivity is associated with myocardial infarction in premenopausal women: a population-based case-control study. J. Thromb. Haemost., 2010-01-30;8(5):906-13. 2010-01-30 [PMID: 20128867] (Human)
• Araujo Penna I, Canella PR, Vieira CS, Silva de Sa MF, dos Reis RM, Ferriani RA Cardiovascular risk factors are reduced with a low dose of acarbose in obese patients with polycystic ovary syndrome. Fertil. Steril., 2007-04-06;88(2):519-22. 2007-04-06 [PMID: 17418836] (Human)
• Huck V, Niemeyer A, Goerge T, Schnaeker EM, Ossig R, Rogge P, Schneider MF, Oberleithner H, Schneider SW Delay of acute intracellular pH recovery after acidosis decreases endothelial cell activation. J. Cell. Physiol., 2007-05-01;211(2):399-409. 2007-05-01 [PMID: 17167769] (Human)
• Di Nisio M, Niers TM, Reitsma PH, Buller HR Plasma cytokine and P-selectin levels in advanced malignancy: prognostic value and impact of low-molecular weight heparin administration. Cancer, 2005-11-15;104(10):2275-81. 2005-11-15 [PMID: 16216004] (Human)

FAQs for P-Selectin/CD62P (DY137). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: SELP