Human LYVE-1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human LYVE-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: LYVE1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human LYVE-1 DuoSet ELISA, 15 Plate

• cell surface retention sequence binding protein-1
• Cell surface retention sequence-binding protein 1
• CRSBP1
• CRSBP-1
• extracellular link domain containing 1
• extracellular link domain-containing 1
• Extracellular link domain-containing protein 1
• HAR
• Hyaluronic acid receptor
• lymphatic vessel endothelial hyaluronan receptor 1
• lymphatic vessel endothelial hyaluronic acid receptor 1
• LYVE1
• LYVE-1
• UNQ230/PRO263
• XLKD1

Background

Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia.

LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium. Roles for LYVE-1 on these cell and tissue types remain to be determined.

Publications for LYVE-1 (DY2089)(5)

Publications using DY2089

• Tran, THM;Wang, R;Kim, H;Kim, YJ; The anti-inflammation and skin-moisturizing effects of Boehmeria tricuspis-mediated biosynthesized gold nanoparticles in human keratinocytes Frontiers in pharmacology 2023-10-06 [PMID: 37869754] (Human)
• D Dai, C Huang, J Ni, Z Zhu, H Han, J Zhu, R Zhang Serum sLYVE-1 is not associated with coronary disease but with renal dysfunction: a retrospective study Sci Rep, 2019-07-25;9(1):10816. 2019-07-25 [PMID: 31346234] (Human)
• AM Courtwrigh, AM Lamattina, PH Louis, AJ Trindade, P Burkett, J Imani, S Shrestha, M Divo, S Keller, IO Rosas, HJ Goldberg, S El-Chemaly Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients Sci Rep, 2019-06-21;9(1):9003. 2019-06-21 [PMID: 31227795] (Human)
• EJ Lim, Y Suh, KC Yoo, JH Lee, IG Kim, MJ Kim, JH Chang, SG Kang, SJ Lee Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells Oncotarget, 2017-01-03;8(1):1438-1448. 2017-01-03 [PMID: 27903965] (Human)
• Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)

Bioinformatics

• Gene Symbol: LYVE1