Human IL-6R alpha Quantikine ELISA Kit

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human IL-6R alpha Quantikine ELISA Kit Summary

Background
The Quantikine Human IL-6 sR Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-6 sR in cell culture supernates, serum, plasma, and urine. It contains recombinant human IL-6 sR produced in Sf 21 cells and antibodies raised against this protein. This kit has been shown to accurately quantitate the recombinant soluble IL-6 R. Results obtained using natural IL-6 s...R showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-6 sR. Since the measurement of human IL-6 sR by this immunoassay is insensitive to added recombinant human IL-6, it is probable that this measurement corresponds to the total amount of the soluble receptor present in samples ( i.e. the total amount of free receptor plus the total amount of receptor bound to IL-6).
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Specificity
Natural and recombinant human IL-6 sR
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
IL6R

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DR600.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-6R alpha Quantikine ELISA Kit

  • CD126
  • gp80
  • IL-6 R alpha
  • IL6Q
  • IL6R alpha
  • IL-6R alpha
  • IL6R
  • IL-6R-1
  • IL6RA
  • IL-6Ra
  • IL6RQ
  • interleukin 6 receptor

Background

IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for IL-6R alpha (DR600)(36)

We have publications tested in 2 confirmed species: Human, Primate - Macaca mulatta (Rhesus Macaque).


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Human
(34)
Primate - Macaca mulatta (Rhesus Macaque)
(2)
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Showing Publications 1 - 10 of 36. Show All 36 Publications.
Publications using DR600 Applications Species
KP Loh, JA Tooze, BJ Nicklas, SB Kritchevsk, JD Williamson, LR Ellis, BL Powell, TS Pardee, NG Goyal, HD Klepin Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia J Geriatr Oncol, 2019;0(0):. 2019 [PMID: 30962090] (Human) Human
S Ishikawa, M Tasaki, T Kuroda, D Kobayashi, K Saito, Y Nakagawa, M Ikeda, K Takahashi, Y Tomita Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report Transplant. Proc., 2018;50(3):869-872. 2018 [PMID: 29661455] (Human) Human
H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner Stem Cells, 2017;0(0):. 2017 [PMID: 28376564] (Human) Human
Koji Osuka Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas J. Neurotrauma, 2016;0(0):. 2016 [PMID: 28027695] (Human) Human
Prevalent peripheral arterial disease and inflammatory burden BMC Geriatr, 2016;16(1):213. 2016 [PMID: 27938334] (Human) Human
IL-6 trans-signaling is another pathway to upregulate Osteopontin Cytokine, 2016;90(0):88-95. 2016 [PMID: 27863335] (Human) Human
Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS) J Bone Miner Res, 2016;0(0):. 2016 [PMID: 27371811] (Human) Human
P Srikanth, R F Chun, M Hewison, J S Adams, R Bouillon, D Vandersch, N Lane, P M Cawthon, T Dam, E Barrett-C, L B Daniels, J M Shikany, M L Stefanick, J A Cauley, E S Orwoll, C M Nielson Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa, 2016;0(0):1433-2965. 2016 [PMID: 26905270] (Human) Human
Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors. Cancer Res, 2016;76(2):480-90. 2016 [PMID: 26744529] (Human) Human
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE, 2015;10(3):e0119415. 2015 [PMID: 25785838] (Human) Human
Show All 36 Publications.

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Product General Protocols

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FAQs for IL-6R alpha (DR600). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DR600
HRP DR600
HRP DR600

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Bioinformatics

Gene Symbol IL6R