Human IL-2 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-2 DuoSet ELISA, 15 Plate

• Aldesleukin
• IL2
• IL-2
• IL-2lymphokine
• interleukin 2
• interleukin-2
• involved in regulation of T-cell clonal expansion
• Proleukin
• T cell growth factor
• T-cell growth factor
• TCGF

Background

Interleukin 2 (IL-2), also known as T cell growth factor (TCGF), is a 15-18 kDa variably glycosylated alpha -helical polypeptide that is a member of the Common gamma Chain ( gamma c) cytokine family (1-4). It exists as a monomer and has a notably short half-life (< 30 minutes) (1). Human IL-2 is synthesized as a 153 amino acid (aa) precursor that contains a 20 aa signal sequence plus a 133 aa mature region (5, 6). The mature region is alpha -helical in nature, and contains one utilized O-linked glycosylation site at Thr3 plus three cysteines, two of which form an intrachain disulfide bond that is essential for activity (7). Mature human IL-2 shares 73%, 66%, 78% and 97% aa identity with canine, rat, feline and rhesus monkey IL-2, respectively. Although human IL-2 shares only approximately 60% aa identity with the highly polymorphic mouse IL-2, human IL-2 is known to be active on mouse IL-2 responsive cells. Cells reported to secrete IL-2 include gamma δ T cells (8), activated conventional CD4+ and CD8+ T cells (1, 9), neurons (10, 11), microglia (12), and hematopoietic stem cells (13). 

The receptor for IL-2 (IL-2 R) is composed of three subunits, the 55 kDa CD25/IL-2 R alpha chain, the 70 kDa IL-2 R beta chain, and the 65 kDa Common gamma Chain (1, 3). IL-2 first binds to CD25, the binary complex then recruits IL-2 R beta and gamma c to form the quaternary signaling complex (1, 14). In addition to IL-2, IL-2 R beta is used by IL-15 in its quaternary signaling complex. gamma c also serves as a signaling receptor for IL-4, -7, -9, -15, and -21 (1, 3). 

In vitro studies have shown an important role for IL-2 in T cell activation and expansion. In vivo, IL-2 is critical for the development, maintenance and function of regulatory T cells (Treg) which provide protection against autoimmune disease. On the other hand, IL-2 can also promote autoimmune inflammation in target organs through its roles in regulating the expression of T cell trafficking genes, and production of Th2 cytokines. Within the CD8+ T cell subset, IL-2 is essential for optimal primary responses and differentiation into terminal effector cells. IL-2 also promotes the development of activated CD8+ T cells into memory cells. (1).

Publications for IL-2 (DY202)(75)

Publications using DY202

• Majocchi, S;Lloveras, P;Nouveau, L;Legrand, M;Viandier, A;Malinge, P;Charreton, M;Raymond, C;Pace, E;Millard, B;Svensson, L;Kelpšas, V;Anceriz, N;Salgado-Pires, S;Daubeuf, B;Magistrelli, G;Gueneau, F;Moine, V;Masternak, K;Shang, L;Fischer, N;Ferlin, W; NI-3201 Is a Bispecific Antibody Mediating PD-L1-Dependent CD28 Co-stimulation on T Cells for Enhanced Tumor Control Cancer Immunology Research 2025-01-06 [PMID: 39760515] (Human)
• Xue, X;Gajic, ZZ;Caragine, CM;Legut, M;Walker, C;Kim, JYS;Wang, X;Yan, RE;Wessels, HH;Lu, C;Bapodra, N;Gürsoy, G;Sanjana, NE; Paired CRISPR screens to map gene regulation in cis and trans bioRxiv : the preprint server for biology 2024-11-27 [PMID: 39651170] (Human)
• Aleksandr, G;Andrei, V;Maria, P;Iana, S;Aleksandr, D;Anna, Z;Daria, Z;Aleksei, A;Mikhail, S;Evgeny, I;Valery, S;Pavel, I; Preclinical comparison of prolgolimab, pembrolizumab and nivolumab Scientific reports 2024-10-04 [PMID: 39367001] (Human)
• Pascual-Pasto, G;McIntyre, B;Hines, MG;Giudice, AM;Garcia-Gerique, L;Hoffmann, J;Mishra, P;Matlaga, S;Lombardi, S;Shraim, R;Schürch, PM;Yarmarkovich, M;Hofmann, TJ;Alikarami, F;Martinez, D;Tsang, M;Gil-de-Gómez, L;Spear, TT;Bernt, KM;Wolpaw, AJ;Dimitrov, DS;Li, W;Bosse, KR; CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma Nature communications 2024-08-21 [PMID: 39164224] (Human)
• da Costa Teixeira, LA;Soares, LA;Lima, LP;Avelar, NCP;de Moura, JA;Leopoldino, AAO;Figueiredo, PHS;Parentoni, AN;Mendonça, VA;Lacerda, ACR; Cognitive function is associated with performance in time up and go test and with leptin blood levels in community-dwelling older women Scientific reports 2024-04-29 [PMID: 38684691] (Human)
• Augusto da Costa Teixeira, L;Rocha-Vieira, E;Aparecida Soares, L;Mota de Oliveira, F;Aparecida Oliveira Leopoldino, A;Netto Parentoni, A;Amaral Mendonça, V;Cristina Rodrigues Lacerda, A; The strong inverse association between plasma concentrations of soluble tumor necrosis factor receptors type 1 with adiponectin/leptin ratio in older women Cytokine 2024-01-27 [PMID: 38281360] (Human)
• Manna, L;Rapuano Lembo, R;Yoshioka, A;Nakamura, K;Passariello, M;De Lorenzo, C; A Comparison of the Antitumor Efficacy of Novel Multi-Specific Tribodies with Combinations of Approved Immunomodulatory Antibodies Cancers 2023-11-09 [PMID: 38001604] (Human)
• Zobel, CM;Wenzel, W;Krüger, JP;Baumgarten, U;Wagelöhner, T;Neumann, N;Foroutan, B;Müller, R;Müller, A;Rauschning, D;Schü beta ler, M;Scheit, L;Weinreich, F;Oltmanns, K;Keidel, F;Koch, M;Spethmann, S;Schreiner, M; Serum interleukin-6, procalcitonin, and C-reactive protein at hospital admission can identify patients at low risk for severe COVID-19 progression Frontiers in microbiology 2023-10-23 [PMID: 37937220] (Human)
• Mellergaard, M;Skovbakke, SL;Jepsen, SD;Panagiotopoulou, N;Hansen, ABR;Tian, W;Lund, A;Høgh, RI;Møller, SH;Guérillot, R;Hayes, AS;Erikstrup, LT;Andresen, L;Peleg, AY;Larsen, AR;Stinear, TP;Handberg, A;Erikstrup, C;Howden, BP;Goletz, S;Frees, D;Skov, S; Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor mBio 2023-10-05 [PMID: 37796131]
• Zeng, S;Zeng, M;Yuan, S;He, L;Jin, Y;Huang, J;Zhang, M;Yang, M;Pan, Y;Wang, Z;Chen, Y;Xu, X;Huang, W; Discovery of potent and selective HPK1 inhibitors based on the 2,4-disubstituted pyrimidine scaffold with immune modulatory properties for ameliorating T cell exhaustion Bioorganic chemistry 2023-10-01 [PMID: 37536217] (Human)
• da Costa Teixeira, LA;Avelar, NCP;Peixoto, MFD;Parentoni, AN;Santos, JMD;Pereira, FSM;Danielewicz, AL;Leopoldino, AAO;Costa, SP;Arrieiro, AN;Soares, LA;da Silva Lage, VK;Prates, ACN;Taiar, R;de Carvalho Bastone, A;Oliveira, VC;Oliveira, MX;Costa, HS;Nobre, JNP;Brant, FP;Duarte, TC;Figueiredo, PHS;Mendonça, VA;Lacerda, ACR; Inflammatory biomarkers at different stages of Sarcopenia in older women Scientific reports 2023-06-26 [PMID: 37365209] (Human)
• Lan, X;Yang, TTC;Wang, Y;Qu, B;Rong, S;Song, N; Characterization of 405B8H3(D-E), a newly engineered high affinity chimeric LAG-3 antibody with potent antitumor activity FEBS open bio 2023-05-17 [PMID: 37302810] (Human)
• Palaniyandi, S;Strattan, E;Kumari, R;Mysinger, M;Hakim, N;Kesler, MV;Apatira, M;Bittencourt, F;Wang, L;Jia, Z;Gururaja, TL;Hill, RJ;Hildebrandt, GC; Combinatorial inhibition of Tec kinases BTK and ITK is beneficial in ameliorating murine sclerodermatous chronic graft versus host disease Bone marrow transplantation 2023-05-09 [PMID: 37160943] (Human)
• D Rasoulouni, N Santana-Ma, A Gutwillig, L Farhat-You, L Tal, S Amar, M Milyavsky, SSNA Muddineni, N Solomon, H Shpilt, S Dotan, N Pilpel, C Waskow, M Feinmesser, P Rider, Y Carmi T Cells Expressing a Modified FcgammaRI Exert Antibody-Dependent Cytotoxicity and Overcome the Limitations of CAR T-cell Therapy against Solid Tumors Cancer Immunology Research, 2023-06-02;0(0):OF1-OF18. 2023-06-02 [PMID: 37070661] (Human)
• LAC Teixeira, JM Dos Santos, AN Parentoni, LP Lima, TC Duarte, FP Brant, CDC Neves, FSM Pereira, NCP Avelar, AL Danielewic, AAO Leopoldino, SP Costa, AN Arrieiro, LA Soares, ACN Prates, JNP Nobre, A de Carvalh, VC de Oliveir, MX Oliveira, PH Scheidt Fi, HS Costa, V Amaral Men, R Taiar, AC Rodrigues Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study Journal of Clinical Medicine, 2022-12-02;11(23):. 2022-12-02 [PMID: 36498747] (Human)
• Y Zhang, Q Zhuang, F Wang, C Zhang, C Xu, A Gu, WH Zhong, Y Hu, X Zhong Co-expression IL-15 receptor alpha with IL-15 reduces toxicity via limiting IL-15 systemic exposure during CAR-T immunotherapy Oncogene, 2022-09-27;20(1):432. 2022-09-27 [PMID: 36167591] (Human)
• V Yekehfalla, S Pahlavanne, A Sayadmanes, Z Momtahan, B Ma, M Basiri Generation and Functional Characterization of PLAP CAR-T Cells against Cervical Cancer Cells Biomolecules, 2022-09-14;12(9):. 2022-09-14 [PMID: 36139135] (Human)
• C Amormino, V Tedeschi, G Paldino, S Arcieri, MT Fiorillo, A Paiardini, L Tuosto, M Kunkl SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity Cells, 2022-08-15;11(16):. 2022-08-15 [PMID: 36010602] (Human)
• A Rosewell S, C Porter, G Biegert, L Jatta, M Suzuki HydrAd: A Helper-Dependent Adenovirus Targeting Multiple Immune Pathways for Cancer Immunotherapy Oncogene, 2022-06-02;14(11):. 2022-06-02 [PMID: 35681750] (Human)
• M Passariell, A Yoshioka, K Takahashi, SI Hashimoto, R Rapuano Le, L Manna, K Nakamura, C De Lorenzo Novel Bi-Specific Immuno-Modulatory Tribodies Potentiate T Cell Activation and Increase Anti-Tumor Efficacy International Journal of Molecular Sciences, 2022-03-23;23(7):. 2022-03-23 [PMID: 35408827] (Human)
• MJ Tosiek, K Groesser, A Pekcec, M Zwirek, G Murugesan, E Borges Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages&#039; Function but Does Not Trigger the Adaptive T Cell Immune Response Journal of Immunology Research, 2022-02-25;2022(0):9926305. 2022-02-25 [PMID: 35252461] (Human)
• C Vetrei, M Passariell, G Froechlich, R Rapuano Le, E Sasso, N Zambrano, C De Lorenzo Novel Combinations of Human Immunomodulatory mAbs Lacking Cardiotoxic Effects for Therapy of TNBC Cancers, 2021-12-27;14(1):. 2021-12-27 [PMID: 35008285] (Human)
• Y Xiao, P Chen, C Luo, Z Xu, X Li, L Liu, L Zhao Discovery of a novel anti PD-L1 X TIGIT bispecific antibody for the treatment of solid tumors Cancer treatment and research communications, 2021-09-27;29(0):100467. 2021-09-27 [PMID: 34598062] (Human)
• KP Eidell, A Lovy, NR Sylvain, FA Scangarell, HI Muendlein, MJ Ophir, K Nguyen, MC Seminario, SC Bunnell LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors Journal of Cell Science, 2021-08-27;0(0):. 2021-08-27 [PMID: 34279667] (Human)
• S Shi, Q Zhao, C Ke, S Long, F Zhang, X Zhang, Y Li, X Liu, H Hu, S Yin Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and KV1.3 Channels Frontiers in Pharmacology, 2021-06-25;12(0):685092. 2021-06-25 [PMID: 34248635] (Human)
• N Aschmoneit, S Steinlein, L Kühl, O Seifert, RE Kontermann A scDb-based trivalent bispecific antibody for T-cell-mediated killing of HER3-expressing cancer cells Scientific Reports, 2021-07-06;11(1):13880. 2021-07-06 [PMID: 34230555] (Human)
• R Sun, Y Zhou, L Han, Z Pan, J Chen, H Zong, Y Bian, H Jiang, B Zhang, J Zhu A Rational Designed Novel Bispecific Antibody for the Treatment of GBM Biomedicines, 2021-06-03;9(6):. 2021-06-03 [PMID: 34204931] (Human)
• C Vetrei, M Passariell, G Froechlich, R Rapuano Le, N Zambrano, C De Lorenzo Immunomodulatory mAbs as Tools to Investigate on Cis-Interaction of PD-1/PD-L1 on Tumor Cells and to Set Up Methods for Early Screening of Safe and Potent Combinatorial Treatments Cancers, 2021-06-08;13(12):. 2021-06-08 [PMID: 34201082] (Human)
• R Tewari, B Shayahati, Y Fan, AM Akimzhanov T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells The Journal of Biological Chemistry, 2021-01-19;0(0):100311. 2021-01-19 [PMID: 33482200] (Human)
• GR Kathamuthu, K Moideen, R Sridhar, D Baskaran, S Babu Altered plasma levels of &amp;betaC and &amp;gammaC chain cytokines and post-treatment modulation in tuberculous lymphadenitis Cytokine, 2020-12-17;138(0):155405. 2020-12-17 [PMID: 33341600] (Human)
• HS Lee, GS Jeong Aromadendrin Inhibits T Cell Activation via Regulation of Calcium Influx and NFAT Activity Molecules, 2020-10-08;25(19):. 2020-10-08 [PMID: 33050076] (Human)
• L Li, Y Gao, R Srivastava, W Wang, Q Xiong, Z Fang, A Pelayo, C Denson, A Goswami, R Harari-Ste, Z Yang, L Weng, LS Qi, FM Marincola Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKK? complex inhibitor BX795 Journal of Translational Medicine, 2020-09-23;18(1):363. 2020-09-23 [PMID: 32967676] (Human)
• M Liu, X Wang, W Li, X Yu, P Flores-Vil, ZY Xu-Monette, L Li, M Zhang, KH Young, X Ma, Y Li Targeting PD-L1 in non-small cell lung cancer using CAR T cells Oncogenesis, 2020-08-13;9(8):72. 2020-08-13 [PMID: 32792499] (Human)
• M Passariell, C Vetrei, E Sasso, G Froechlich, C Gentile, AM D'Alise, N Zambrano, E Scarselli, A Nicosia, C De Lorenzo Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells Cancers (Basel), 2020-08-06;12(8):. 2020-08-06 [PMID: 32781690] (Human)
• I Evnouchido, P Chappert, S Benadda, A Zucchetti, M Weimershau, M Bens, V Caillens, D Koumantou, S Lotersztaj, P van Endert, J Davoust, P Guermonpre, C Hivroz, DA Gross, L Saveanu IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses Nat Commun, 2020-06-02;11(1):2779. 2020-06-02 [PMID: 32487999] (Human)
• M Herrera, C Vera, Y Keynan, ZV Rueda Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review J Immunol Res, 2020-04-21;2020(0):8074183. 2020-04-21 [PMID: 32377537] (Human)
• S Guedan, A Madar, V Casado-Med, C Shaw, A Wing, F Liu, RM Young, CH June, AD Posey Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability J. Clin. Invest., 2020-06-01;130(6):3087-3097. 2020-06-01 [PMID: 32069268] (Human)
• M Passariell, S Camorani, C Vetrei, S Ricci, L Cerchia, C De Lorenzo Ipilimumab and Its Derived EGFR Aptamer-Based Conjugate Induce Efficient NK Cell Activation against Cancer Cells Cancers (Basel), 2020-02-01;12(2):. 2020-02-01 [PMID: 32024070] (Human)
• B Vis, RE Hewitt, TP Monie, C Fairbairn, SD Turner, SD Kinrade, JJ Powell Ultrasmall silica nanoparticles directly ligate the T cell receptor complex Proc. Natl. Acad. Sci. U.S.A., 2019-12-23;0(0):. 2019-12-23 [PMID: 31871161] (Human)
• S Martínez-H, V Sánchez-Ga, A Herrero-Ce, Á Vinué, JT Real, JF Ascaso, DJ Burks, H González-N Type 1 diabetic mellitus patients with increased atherosclerosis risk display decreased CDKN2A/2B/2BAS gene expression in leukocytes J Transl Med, 2019-07-12;17(1):222. 2019-07-12 [PMID: 31299986] (Human)
• J Celis-Guti, P Blattmann, Y Zhai, N Jarmuzynsk, K Ruminski, C Grégoire, Y Ounoughene, F Fiore, R Aebersold, R Roncagalli, M Gstaiger, B Malissen Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy Cell Rep, 2019-06-11;27(11):3315-3330.e7. 2019-06-11 [PMID: 31189114] (Human)
• L Su, P Pan, P Yan, Y Long, X Zhou, X Wang, R Zhou, B Wen, L Xie, D Liu Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis Sci Rep, 2019-04-05;9(1):5747. 2019-04-05 [PMID: 30952998] (Human)
• H Siddiqui, HM Haniffa, A Jabeen, AU -Rahman, MI Choudhary Sulphamethazine derivatives as immunomodulating agents: New therapeutic strategies for inflammatory diseases PLoS ONE, 2018-12-19;13(12):e0208933. 2018-12-19 [PMID: 30566465] (Human)
• C Diener, M Hart, D Alansary, V Poth, B Walch-Rück, J Menegatti, F Grässer, T Fehlmann, S Rheinheime, BA Niemeyer, HP Lenhof, A Keller, E Meese Modulation of intracellular calcium signaling by microRNA-34a-5p Cell Death Dis, 2018-09-27;9(10):1008. 2018-09-27 [PMID: 30262862] (Human)
• R Liu, J Merola, TD Manes, L Qin, GT Tietjen, F López-Girá, V Broecker, C Fang, C Xie, PM Chen, NC Kirkiles-S, D Jane-Wit, JS Pober Interferon-? converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1 JCI Insight, 2018-03-08;3(5):. 2018-03-08 [PMID: 29515027] (Human)
• GJ Dekkema, WH Abdulahad, T Bijma, SM Moran, L Ryan, MA Little, CA Stegeman, P Heeringa, JF Sanders Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study Nephrol. Dial. Transplant., 2019-02-01;0(0):. 2019-02-01 [PMID: 29506265] (Human)
• Guedan S, Posey A, Shaw C, Wing A, Da T, Patel P, McGettigan S, Casado-Medrano V, Kawalekar O, Uribe-Herranz M, Song D, Melenhorst J, Lacey S, Scholler J, Keith B, Young R, June C Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. JCI Insight, 2018-01-11;3(1):. 2018-01-11 [PMID: 29321369] (Human)
• W Li, Y Wu, D Kong, H Yang, Y Wang, J Shao, Y Feng, W Chen, L Ma, T Ying, DS Dimitrov One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells Sci Rep, 2017-08-22;7(1):9130. 2017-08-22 [PMID: 28831040] (Human)
• JD Graci, D Michaels, G Chen, GM Schiralli, S Nodder, M Weetall, GM Karp, Z Gu, JM Colacino, AJ Henderson Identification of benzazole compounds that induce HIV-1 transcription PLoS ONE, 2017-06-28;12(6):e0179100. 2017-06-28 [PMID: 28658263] (Human)
• Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1? and IL-18 in tuberculous lymphadenitis Cytokine, 2016-10-26;90(0):66-72. 2016-10-26 [PMID: 27794266] (Human)
• Benjamin F Cravatt Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells Sci Signal, 2016-09-13;9(445):rs10. 2016-09-13 [PMID: 27625306] (Mouse)
• Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation EMBO J, 2016-05-06;0(0):. 2016-05-06 [PMID: 27154205] (Human)
• Grundy S, Plumb J, Kaur M, Ray D, Singh D Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells. Respir Res, 2016-01-25;17(1):9. 2016-01-25 [PMID: 26809346] (Human)
• Guirado E, Mbawuike U, Keiser T, Arcos J, Azad A, Wang S, Schlesinger L Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model. MBio, 2015-02-17;6(1):e02537-14. 2015-02-17 [PMID: 25691598] (Human)
• Tanaka K, Ohgo Y, Katayanagi Y, Yasui K, Hiramoto S, Ikemoto H, Nakata Y, Miyoshi N, Isemura M, Ohashi N, Imai S Anti-inflammatory effects of green soybean extract irradiated with visible light. Sci Rep, 2014-04-22;4(0):4732. 2014-04-22 [PMID: 24751752] (Human)
• Kis-Toth K, Tsokos G Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival. J Immunol, 2014-03-26;192(9):4436-42. 2014-03-26 [PMID: 24670806] (Human)
• Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Human)
• Rao M, Vogelzang A, Kaiser P, Schuerer S, Kaufmann S, Gengenbacher M The tuberculosis vaccine candidate Bacillus Calmette-Guerin DeltaureC::hly coexpressing human interleukin-7 or -18 enhances antigen-specific T cell responses in mice. PLoS ONE, 2013-11-13;8(11):e78966. 2013-11-13 [PMID: 24236077] (Human)
• Yu F, Wang X, Guo Z, Bartlett D, Gottschalk S, Song X T-cell engager-armed oncolytic vaccinia virus significantly enhances antitumor therapy. Mol Ther, 2013-10-17;22(1):102-11. 2013-10-17 [PMID: 24135899] (Human)
• Kim H, Na B, Kwon M, Ko Y, Han W, Jun C Dynamic motile T cells highly respond to the T cell stimulation via PI3K-Akt and NF-kappaB pathways. PLoS ONE, 2013-03-26;8(3):e59793. 2013-03-26 [PMID: 23555783] (Human)
• Verma N, Dempsey E, Long A, Davies A, Barry S, Fallon P, Volkov Y, Kelleher D Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-beta signaling. J Biol Chem, 2012-06-15;287(32):27204-16. 2012-06-15 [PMID: 22707713] (Human)
• Xu D, Lin L, Lin X Immunoregulation of autocrine prolactin: suppressing the expression of costimulatory molecules and cytokines in T lymphocytes by prolactin receptor knockdown. Cell. Immunol., 2010-03-02;263(1):71-8. 2010-03-02 [PMID: 20307875] (Human)
• Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, O'Kennedy R, O'Neill SJ, McElvaney NG IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J. Immunol., 2009-12-21;184(3):1642-52. 2009-12-21 [PMID: 20026745] (Human)
• Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J. Immunol., 2008-05-01;180(9):6000-9. 2008-05-01 [PMID: 18424720] (Human)
• Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J. Clin. Invest., 2007-12-01;117(12):3664-3672. 2007-12-01 [PMID: 17992260] (Human)
• Schwarz EC, Kummerow C, Wenning AS, Wagner K, Sappok A, Waggershauser K, Griesemer D, Strauss B, Wolfs MJ, Quintana A, Hoth M Calcium dependence of T cell proliferation following focal stimulation. Eur. J. Immunol., 2007-10-01;37(10):2723-33. 2007-10-01 [PMID: 17899547] (Human)
• Barker SE, Grosse SM, Siapati EK, Kritz A, Kinnon C, Thrasher AJ, Hart SL Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12. Br. J. Cancer, 2007-06-26;97(2):210-7. 2007-06-26 [PMID: 17595664] (Human)
• Eidenschenk C, Jouanguy E, Alcais A, Mention JJ, Pasquier B, Fleckenstein IM, Puel A, Gineau L, Carel JC, Vivier E, Le Deist F, Casanova JL Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. J. Immunol., 2006-12-15;177(12):8835-43. 2006-12-15 [PMID: 17142786] (Human)
• Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation. Immunology, 2006-10-01;119(2):203-11. 2006-10-01 [PMID: 17005002] (Human)
• Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood, 2006-04-06;108(3):965-73. 2006-04-06 [PMID: 16601243] (Human)
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FAQs for IL-2 (DY202). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL2