IGFBP-3 Products

Description

IGFBP3 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Bioinformatics

Entrez	16009 Mouse 24484 Rat 3486 Human
Uniprot	AAH64987.1 Human CAA46087 Human NP_000589 Human NP_001013416 Human NP_001013416.1 Human P17936 Human
Product By Gene ID	3486
Alternate Names	acid stable subunit of the 140 K IGF complex binding protein 29 binding protein 53 growth hormone-dependent binding protein IBP-3 IBP3BP-53 IGF-binding protein 3 IGFBP-3 insulin-like growth factor binding protein 3 insulin-like growth factor-binding protein 3

Research Areas for IGFBP-3

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Apoptosis
Prostate Cancer