Reactivity | HuSpecies Glossary |
Applications | WB, ELISA(Cap) |
Clone | 110211 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Unconjugated |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human IGFBP-6 Ala25-Gly240 Accession # P24592 |
Specificity | Detects human IGFBP-6 in ELISAs and Western blots. In Western blots, this antibody does not cross-react with recombinant human (rh) IGFBP-1, -2, -3, -4, -5, rmIGFBP-3, -5, or -6. |
Source | N/A |
Isotype | IgG2b |
Clonality | Monoclonal |
Host | Mouse |
Gene | IGFBP6 |
Purity | Protein A or G purified from ascites |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | ELISA Detection: Human IGFBP-6 Biotinylated Antibody (Catalog number BAF876) Standard: Recombinant Human IGFBP-6 (Catalog number 876-B6) |
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Publications |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS. |
Preservative | No Preservative |
Purity | Protein A or G purified from ascites |
Reconstitution Instructions | Reconstitute at 0.5 mg/mL in sterile PBS. |
The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-transitional modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Human IGFBP-6 cDNA encodes a 240 amino acid (aa) residue precursor protein with a putative 24 aa residue signal peptide that is processed to generate the 216 aa residue mature protein that is O-glycosylated. IGFBP-6 is expressed in ovarian cells, prostatic cells, and fibroblasts. IGFBP-6 is found predominantly in CSF and serum. IGFBP-6 binds preferentially to IGF-II, exhibiting a 2-fold higher affinity for IGF-II than for IGF-I.
Secondary Antibodies |
Isotype Controls |
Diseases for IGFBP-6 Antibody (MAB8761)Discover more about diseases related to IGFBP-6 Antibody (MAB8761).
| Pathways for IGFBP-6 Antibody (MAB8761)View related products by pathway.
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PTMs for IGFBP-6 Antibody (MAB8761)Learn more about PTMs related to IGFBP-6 Antibody (MAB8761).
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