Human IGFBP-3 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IGFBP-3 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IGFBP3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IGFBP-3 DuoSet ELISA, 15 Plate

• acid stable subunit of the 140 K IGF complex
• binding protein 29
• binding protein 53
• growth hormone-dependent binding protein
• IBP-3
• IBP3BP-53
• IGF-binding protein 3
• IGFBP3
• IGFBP-3
• insulin-like growth factor binding protein 3
• insulin-like growth factor-binding protein 3

Background

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

Publications for IGFBP-3 (DY675)(13)

Publications using DY675

• KN Lee, KH Park, YM Kim, I Cho, TE Kim Prediction of emergency cerclage outcomes in women with cervical insufficiency: The role of inflammatory, angiogenic, and extracellular matrix-related proteins in amniotic fluid PLoS ONE, 2022-05-10;17(5):e0268291. 2022-05-10 [PMID: 35536791] (Human)
• Y Chikata, H Iwata, K Miyosawa, T Koike, H Yasuda, T Funamizu, S Doi, H Endo, H Wada, R Naito, M Ogita, T Dohi, T Kasai, K Isoda, S Okazaki, K Miyauchi, T Minamino Dipeptidyl peptidase-4 inhibitors reduced long-term cardiovascular risk in diabetic patients after percutaneous coronary intervention via insulin-like growth factor-1 axis Scientific Reports, 2022-03-24;12(1):5129. 2022-03-24 [PMID: 35332212] (Human)
• M Darnaud, F De Vadder, P Bogeat, L Boucinha, AL Bulteau, A Bunescu, C Couturier, A Delgado, H Dugua, C Elie, A Mathieu, T Novotná, DA Ouattara, S Planel, A Saliou, D Šr?tková, J Yansouni, B Stecher, M Schwarzer, F Leulier, A Tamellini A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes Nature Communications, 2021-11-18;12(1):6686. 2021-11-18 [PMID: 34795236] (Mouse)
• F Kurniawan, DL Tahapary, K de Ruiter, E Yunir, NR Biermasz, JWA Smit, T Supali, E Sartono, M Yazdanbakh, P Soewondo Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia Sci Rep, 2020-11-04;10(1):19023. 2020-11-04 [PMID: 33149205] (Human)
• LWM Loo, K Nishibun, L Welsh, T Makolo, CD Chong, I Pagano, H Yu, EO Bantum Using a cultural dance program to increase sustainable physical activity for breast cancer survivors-A pilot study Complement Ther Med, 2019-09-21;47(0):102197. 2019-09-21 [PMID: 31780003] (Human)
• Marco Santoro MODELING STROMA-INDUCED DRUG RESISTANCE IN A TISSUE-ENGINEERED TUMOR MODEL OF EWING SARCOMA Tissue Eng Part A, 2017-01-01;0(0):. 2017-01-01 [PMID: 27923328] (Human)
• Musil , J, Kutinova , L, Zurkova , K, Hainz , P, Babiarova , K, Krystofova , J, Nemeckova , S Antitumor activity and immunogenicity of recombinant vaccinia virus expressing HPV 16 E7 protein SigE7LAMP is enhanced by high-level coexpression of IGFBP-3. Cancer Gene Ther, 2014-02-21;21(3):115-25. 2014-02-21 [PMID: 24556712] (Mouse, Primate - Chlorocebus aethiops (African Green Monkey))
• Nguyen KH, Yao XH, Moulik S, Mishra S, Nyomba BL Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice via an Inhibition of Insulin Secretion. Endocrinology, 2011-03-29;152(6):2184-96. 2011-03-29 [PMID: 21447640] (Human)
• Oy GF, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo GM, Florenes VA Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma. Int. J. Cancer, 2010-01-15;126(2):350-61. 2010-01-15 [PMID: 19588500] (Human)
• Rosendahl AH, Forsberg G IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells. Kidney Int., 2006-09-13;70(9):1584-90. 2006-09-13 [PMID: 16969385] (Human)
• Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J, Martin T, Goodlett DR Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am. J. Pathol., 2006-07-01;169(1):86-95. 2006-07-01 [PMID: 16816363] (Human)
• Congote LF, DiFalco MR, Gibbs BF Thrombospondin 1, produced by endothelial cells under the action of erythropoietin, stimulates thymidine incorporation into erythroid cells and counteracts the inhibitory action of insulin-like growth factor binding protein 3. Cytokine, 2005-03-23;30(5):248-53. 2005-03-23 [PMID: 15927849] (Human)
• Takaoka M, Harada H, Andl CD, Oyama K, Naomoto Y, Dempsey KL, Klein-Szanto AJ, El-Deiry WS, Grimberg A, Nakagawa H Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res., 2004-11-01;64(21):7711-23. 2004-11-01 [PMID: 15520175] (Human)

FAQs for IGFBP-3 (DY675). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IGFBP3