Human Gas6 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Gas6 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: GAS6

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Gas6 DuoSet ELISA, 15 Plate

• AXLLG
• AXLLGAXL stimulatory factor
• AXSFAXL receptor tyrosine kinase ligand
• DKFZp666G247
• FLJ34709
• Gas6
• GAS-6
• growth arrest-specific 6
• growth arrest-specific protein 6

Background

Gas6 (Growth Arrest Specific 6) is a secreted protein that contains an extensively gamma-carboxylated N-terminal Gla domain and is dependent upon vitamin K for activity. Gas6 signals through the receptors Axl, Dtk/Tyro3, and Mer and is inhibited by shed soluble forms of Axl and Mer. Gas6 protects cells from stress-induced apoptosis and promotes phagocytosis of apoptotic cell debris, promotes platelet activation but inhibits inflammatory cytokine production, and inhibits VEGF-induced angiogenesis, and regulates tumor cell invasiveness.

Publications for Gas6 (DY885B)(23)

Publications using DY885B

• Utsumi, T;Mizuta, H;Seto, Y;Uchibori, K;Nishio, M;Okamoto, I;Katayama, R; AXL-Mediated Drug Resistance in ALK-Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive Fibroblasts Cancer science 2025-02-04 [PMID: 39904499] (Human, Mouse)
• Aydin, N;Kander, T;Schött, U;Hafizi, S; Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients Nutrients 2025-01-19 [PMID: 39861478] (Human)
• Barbu, E;Mihaila, AC;Gan, AM;Ciortan, L;Macarie, RD;Tucureanu, MM;Filippi, A;Stoenescu, AI;Petrea, SV;Simionescu, M;Balanescu, SM;Butoi, E; The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients International journal of molecular sciences 2024-05-08 [PMID: 38791147] (Human)
• Yao, Z;Qi, W;Zhang, H;Zhang, Z;Liu, L;Shao, Y;Zeng, H;Yin, J;Pan, H;Guo, X;Liu, A;Cai, D;Bai, X;Zhang, H; Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis eLife 2023-05-05 [PMID: 37144868] ( Human)
• D Apostolo, D D'Onghia, S Tonello, R Minisini, A Baricich, C Gramaglia, F Patrucco, P Zeppegno, A Acquaviva, PE Balbo, LM Castello, G Cappellano, A Chiocchett, C Gerevini, M Giordano, F Laaguid, M Manfredi, D Raineri, C Rigamonti, R Rolla, V Romano, M Confalonie, P Savoia, E Zavattaro, M Pirisi, B Ruaro, PP Sainaghi, M Bellan, No-More CO Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors International Journal of Molecular Sciences, 2023-03-26;24(7):. 2023-03-26 [PMID: 37047229] (Human)
• Neus Martínez-Bosch, Helena Cristóbal, Mar Iglesias, Meritxell Gironella, Luis Barranco, Laura Visa et al. Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis eBioMedicine 2022-01-01 [PMID: 34973624] (Human)
• U Schött, C Augustsson, L Lilover, CU Nilsson, L Walther-St, T Kander Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study Nutrients, 2021-11-16;13(11):. 2021-11-16 [PMID: 34836355] (Human)
• J Huckriede, SB Anderberg, A Morales, F de Vries, M Hultström, A Bergqvist, JT Ortiz-Pére, JW Sels, K Wichapong, M Lipcsey, M van de Pol, A Larsson, T Luther, C Reutelings, PG de Frutos, R Frithiof, GAF Nicolaes Evolution of NETosis markers and DAMPs have prognostic value in critically ill COVID-19 patients Scientific Reports, 2021-08-03;11(1):15701. 2021-08-03 [PMID: 34344929] (Human)
• T Eichhorn, I Linsberger, L Lauková, C Tripiscian, B Fendl, R Weiss, F König, G Valicek, G Miestinger, C Hörmann, V Weber Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors Mediators of Inflammation, 2021-03-17;2021(0):8395048. 2021-03-17 [PMID: 33790693] (Human)
• J Bordoloi, D Ozah, T Bora, J Kalita, P Manna Gamma-glutamyl carboxylated Gas6 facilitates the prophylactic effect of vitamin K in inhibiting hyperlipidemia-associated inflammatory pathophysiology via arresting MCP-1/ICAM-1 mediated monocyte-hepatocyte adhesion The Journal of nutritional biochemistry, 2021-03-28;0(0):108635. 2021-03-28 [PMID: 33789149] (Human)
• J Vullings, JP Vago, CEJ Waterborg, RM Thurlings, MI Koenders, PLEM van Lent, PM van der Kr, FA Amaral, FAJ van de Loo Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis J Immunol Res, 2020-09-11;2020(0):9690832. 2020-09-11 [PMID: 32964059] (Human)
• A Abu-Thurai, MA Goyette, J Boulais, C Delliaux, C Apcher, C Schott, R Chidiac, H Bagci, MP Thibault, D Davidson, M Ferron, A Veillette, RJ Daly, AC Gingras, JP Gratton, JF Côté AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network Nat Commun, 2020-07-17;11(1):3586. 2020-07-17 [PMID: 32681075] (Human)
• S Alivernini, L MacDonald, A Elmesmari, S Finlay, B Tolusso, MR Gigante, L Petricca, C Di Mario, L Bui, S Perniola, M Attar, M Gessi, AL Fedele, S Chilaka, D Somma, SN Sansom, A Filer, C McSharry, NL Millar, K Kirschner, A Nerviani, MJ Lewis, C Pitzalis, AR Clark, G Ferracciol, I Udalova, CD Buckley, E Gremese, IB McInnes, TD Otto, M Kurowska-S Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis Nat. Med., 2020-06-29;0(0):. 2020-06-29 [PMID: 32601335] (Human)
• SJ Wang, R Li, TSC Ng, G Luthria, MJ Oudin, M Prytyskach, RH Kohler, R Weissleder, DA Lauffenbur, MA Miller Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy Sci Adv, 2020-05-22;6(21):eaaz8521. 2020-05-22 [PMID: 32494745] (Human)
• T Shibata, A Makino, R Ogata, S Nakamura, T Ito, K Nagata, Y Terauchi, T Oishi, M Fujieda, Y Takahashi, M Ato Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization J. Clin. Invest., 2020-06-01;0(0):. 2020-06-01 [PMID: 32364537] (Human)
• PY Dumas, C Naudin, S Martin-Lan, B Izac, L Casetti, O Mansier, B Rousseau, A Artus, M Dufossée, A Giese, P Dubus, A Pigneux, V Praloran, A Bidet, A Villacrece, AV Guitart, N Milpied, O Kosmider, I Vigon, V Desplat, I Dusanter-F, JM Pasquet Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5- and hypoxia- dependent up-regulation of AXL Haematologica, 2019-03-28;0(0):. 2019-03-28 [PMID: 30923103] (Human)
• C Dantas-Bar, T Lesluyes, FL Loarer, F Chibon, I Treilleux, JM Coindre, P Meeus, M Brahmi, O Bally, I Ray-Coquar, MP Sunyach, AL Cesne, O Mir, S Bonvalot, M Toulmonde, A Italiano, P Saintigny, M Jean-Denis, F Ducimetier, D Ranchere, H El Sayadi, L Alberti, JY Blay Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma Br. J. Cancer, 2017-10-12;117(12):1787-1797. 2017-10-12 [PMID: 29024938] (Human)
• SN Cross, JA Potter, P Aldo, JY Kwon, M Pitruzzell, M Tong, S Guller, CV Rothlin, G Mor, VM Abrahams Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation J. Immunol., 2017-09-15;0(0):. 2017-09-15 [PMID: 28916522] (Human)
• M Kurowska-S, S Alivernini, EG Melchor, A Elmesmari, B Tolusso, C Tange, L Petricca, DS Gilchrist, G Di Sante, C Keijzer, L Stewart, C Di Mario, V Morrison, JM Brewer, D Porter, S Milling, RD Baxter, D McCarey, E Gremese, G Lemke, G Ferracciol, C McSharry, IB McInnes MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis Nat Commun, 2017-06-22;8(0):15877. 2017-06-22 [PMID: 28639625] (Human)
• Axl is required for TGF-?2-induced dormancy of prostate cancer cells in the bone marrow Sci Rep, 2016-11-07;6(0):36520. 2016-11-07 [PMID: 27819283] (Human)
• Waizenegger J, Ben-Batalla I, Weinhold N, Meissner T, Wroblewski M, Janning M, Riecken K, Binder M, Atanackovic D, Taipaleenmaeki H, Schewe D, Sawall S, Gensch V, Cubas-Cordova M, Seckinger A, Fiedler W, Hesse E, Kroger N, Fehse B, Hose D, Klein B, Raab M, Pantel K, Bokemeyer C, Loges S Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma. Leukemia, 2014-08-08;29(3):696-704. 2014-08-08 [PMID: 25102945] (Human)
• Lee , Chien-Hs, Shieh , Yi-Shing, Tsai , Chien-Su, Hung , Yi-Jen, Tsai , Yi-Ting, Lin , Chih-Yua Plasma concentrations predict aortic expression of growth-arrest-specific protein 6 in patients undergoing coronary artery bypass grafting. PLoS ONE, 2013-11-13;8(11):e79452. 2013-11-13 [PMID: 24236135] (Human)
• Shiozawa Y, Pedersen EA, Taichman RS GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp. Hematol., 2009-11-14;38(2):132-40. 2009-11-14 [PMID: 19922767] (Human)

FAQs for Gas6 (DY885B). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: GAS6