Human Fibronectin Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

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Human Fibronectin Protein, CF Summary

Details of Functionality
Measured by its ability to support cell attachment and spreading when used as a substratum for cell culture. In this application, the recommended concentration for this effect is
1‑5 µg/cm2.

Fibronectin can also be added in the media to support cell spreading at a concentration of 0.5-50 µg/mL.
Optimal concentration depends on cell type as well as the application or research objectives.
Human plasma-derived Fibronectin protein
The human plasma used for the isolation of this product was certified by the supplier to be HIV-1 and HBsAg negative at the time of shipment. Human blood products should always be treated in accordance with universal handling precautions.
Protein/Peptide Type
Natural Proteins
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Read Publications using
1918-FN in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 6 months from date of receipt, 2 to 8 °C as supplied.
  • 3 months, 2 to 8 °C under sterile conditions after opening.
Avoid vortexing and excessive agitation.
Supplied as a 0.2 μm filtered solution in Tris-HCl, NaCl and Urea.
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Fibronectin Protein, CF

  • CIG
  • ED-B
  • fibronectin 1
  • Fibronectin
  • FINC
  • FN
  • FN1
  • FNZ
  • GFND
  • GFND2
  • LETS
  • MSF


Fibronectin (Fn) is a large modular glycoprotein that is found as a polymeric fibrillar network in the extracellular matirx (ECM) and as soluble disulfide-linked dimeric protomers in plasma and other body fluids. The protein subunit is made up of three types of homologous structural repeats termed Fn type I, type II, and type III repeats. Multiple isoforms of the protein formed by alternative splicing at numerous sites, resulting in insertions of extra type III domains (EDA and ECB) or parts of the variable type III connecting segment (V/IIICS), have been identified. Fibronectin is a ligand for fibrin, heparin, chondroitin sulfate, collagen/gelatin, and many integrin receptors. It is involved in multiple cellular processes including cell adhesion/migration, blood clotting, morphogenesis, tissue repair, and cell signaling. Fibronectin functions are mediated by the insoluble polymeric fibrils in the ECM. Conversion of the non-functional soluble Fibronectin to Fibronectin fibrils in the ECM is tightly regulated. The process is initiated by binding of Fibronectin to cell surface integrins, resulting in conformational changes and exposure of cryptic epitopes necessary for polymerization (1, 2).

  1. Johansson, S. et al. (1997) Frontiers in Bioscience 2:126.
  2. Geiger, B. et al. (2001) Nature Reviews Molecular Cell Biology 2:793.

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Publications for Fibronectin (1918-FN)(25)

We have publications tested in 4 confirmed species: Human, Mouse, N/A, Xenopus.

We have publications tested in 2 applications: Adhesion Assay, Bioassay.

Filter By Application
Adhesion Assay
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Showing Publications 1 - 10 of 25. Show All 25 Publications.
Publications using 1918-FN Applications Species
L Zhai, Y Liu, W Zhao, Q Chen, T Guo, W Wei, Z Luo, Y Huang, C Ma, F Huang, X Dai Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes Stem Cell Res Ther, 2020;11(1):10. 2020 [PMID: 31900223] (Bioassay, Human) Bioassay Human
NV Ayala-Nune, G Follain, F Delalande, A Hirschler, E Partiot, GL Hale, BC Bollweg, J Roels, M Chazal, F Bakoa, M Carocci, S Bourdoulou, O Faklaris, SR Zaki, A Eckly, B Uring-Lamb, F Doussau, S Cianferani, C Carapito, FMJ Jacobs, N Jouvenet, JG Goetz, R Gaudin Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells Nat Commun, 2019;10(1):4430. 2019 [PMID: 31562326] (Bioassay, Human) Bioassay Human
D Karpova, MP Rettig, J Ritchey, D Cancilla, S Christ, L Gehrs, E Chendamara, MO Evbuomwan, M Holt, J Zhang, G Abou-Ezzi, H Celik, E Wiercinska, W Yang, F Gao, LG Eissenberg, RF Heier, SD Arnett, MJ Meyers, MJ Prinsen, DW Griggs, A Trumpp, PG Ruminski, DM Morrow, HB Bonig, DC Link, JF DiPersio Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells J. Clin. Invest., 2019;129(7):2745-2759. 2019 [PMID: 31085833] (Bioassay, Human) Bioassay Human
Z Yang, H Chen, M Shu, Y Zhang, L Xue, Y Lin DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway Oncol Lett, 2019;17(2):2107-2116. 2019 [PMID: 30719106] (Bioassay, Human) Bioassay Human
H Elamaa, M Kihlström, E Kapiainen, M Kaakinen, I Miinalaine, S Ragauskas, M Cerrada-Gi, S Mering, M Nätynki, L Eklund Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina Elife, 2018;7(0):. 2018 [PMID: 30444491] (Bioassay, Human) Bioassay Human
T He, R Sun, Y Li, ZS Katusic Effects of Brain-Derived Neurotrophic Factor on MicroRNA Expression Profile in Human Endothelial Progenitor Cells Cell Transplant, 2018;0(0):9636897187616. 2018 [PMID: 29860902] (Bioassay, Human) Bioassay Human
J Wang, J Liu, R Zhou, X Ding, Q Zhang, C Zhang, L Li Zika virus infected primary microglia impairs NPCs proliferation and differentiation Biochem. Biophys. Res. Commun., 2018;0(0):. 2018 [PMID: 29453985] (Bioassay, Mouse) Bioassay Mouse
M Hong, H Cheng, L Song, W Wang, Q Wang, D Xu, W Xing Wogonin Suppresses the Activity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion in Human Hepatocellular Carcinoma Molecules, 2018;23(2):. 2018 [PMID: 29439451] (Bioassay) Bioassay
S Sarvi, H Patel, J Li, GL Dodd, H Creedon, M Muir, J Ward, JC Dawson, M Lee, J Culley, DM Salter, AH Sims, A Byron, VG Brunton Kindlin-1 promotes pulmonary breast cancer metastasis Cancer Res., 2018;0(0):. 2018 [PMID: 29330144] (Bioassay, Mouse) Bioassay Mouse
EM Langer, ND Kendsersky, CJ Daniel, GM Kuziel, C Pelz, KM Murphy, MR Capecchi, RC Sears ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells Oncogene, 2017;0(0):. 2017 [PMID: 29084210] (Bioassay, Human) Bioassay Human
Show All 25 Publications.

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Nickel induces migratory and invasive phenotype in human epithelial cells by epigenetically activating ZEB1
By Jamshed Arslan Pharm.D. Nickel (Ni) is a naturally abundant metallic element. It is a major component of stainless steel, coins, and many other items of daily use. Disturbingly, Ni exposure is associated with can...  Read full blog post.

Bad news for stomach cancer: BAMBI protein inhibits gastric carcinoma via TGF-beta/epithelial-mesenchymal transition signaling
By Jamshed Arslan Pharm.D. Gastric carcinoma is the second leading cause of cancer-related deaths worldwide. One of the key features of gastric carcinoma is acidosis, which promotes growth and metastasis of gastric...  Read full blog post.

Alpha-smooth muscle actin and the modulation of endothelial and epithelial cell biology
Actin is essential for a wide range of cell functions, ranging from cell division and chromatin remodeling to vesicle trafficking and maintenance of cellular structure. In fact, mislocalization of actin to cell junctions during development leads t...  Read full blog post.

Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...  Read full blog post.

Fibronectin: Organizing Cell Activity across the ECM
Fibronectin is a glycoprotein found in the extracellular matrix (ECM) that binds to integrins and other components of the ECM such as collagen and fibrin. Under normal physiological conditions, fibronectin is an important factor in cell adhesion, grow...  Read full blog post.

Using the Laminin Antibody in Angiogenesis Research
Laminin is one of a large number of proteins expressed on the basal laminar of the ECM (extracellular matrix). The laminin antibody database covers several proteins, which interact with integrins and other receptor proteins to support cellular differe...  Read full blog post.

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Gene Symbol FN1