Human FABP2/I-FABP DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human FABP2/I-FABP DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: FABP2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human FABP2/I-FABP DuoSet ELISA, 15 Plate

• FABP2
• FABPI
• fatty acid binding protein 2, intestinal
• Fatty acid-binding protein 2
• fatty acid-binding protein, intestinal
• IFABP
• I-FABP
• I-FABPMGC133132
• Intestinal FABP
• Intestinal-type fatty acid-binding protein

Background

Fatty acid binding proteins are small cytoplasmic lipid binding proteins that are expressed in a tissue specific manner. FABPs bind free fatty acids, cholesterol, and retinoids, and are involved in intracellular lipid transport. Circulating FABP levels are used as indicators of tissue damage. Some FABP polymorphisms have been associated with disorders of lipid metabolism and the development of atherosclerosis.

FABP2, also known as intestinal fatty acid binding protein (I-FABP or FABPI) and gut FABP (gFABP), is a member of the cytosolic fatty acid binding protein family. FABP2 mediates the absorption and intracellular transport of dietary long-chain fatty acids. Genetic variations of FABP2 are implicated in obesity and Type II diabetes. Human FABP2 shares 78%, 82%, and 86% amino acid sequence identity with mouse, rat, and canine FABP2, respectively.

Publications for FABP2/I-FABP (DY3078)(30)

Publications using DY3078

• Davison, G;Carswell, AT;Baron, P;Martinez-Gonzalez, B; Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study Physiological reports 2025-11-01 [PMID: 41261949] (Human)
• Reimer-McAtee, M;Serpa, J;McAtee, C;Ortega, E;Somasunderam, A;Arduino, R;Mejia, R;Utay, NS; Impact of intestinal parasitic infections on gut epithelial barrier and inflammation among foreign-born persons living with HIV medRxiv : the preprint server for health sciences 2025-02-05 [PMID: 39974003] (Human)
• Boby, N;Williams, KM;Das, A;Pahar, B; Toll-like Receptor 2 Mediated Immune Regulation in Simian Immunodeficiency Virus-Infected Rhesus Macaques Vaccines 2023-12-17 [PMID: 38140264] (Primate - Macaca mulatta (Rhesus Macaque))
• Sereti, I;Verburgh, ML;Gifford, J;Lo, A;Boyd, A;Verheij, E;Verhoeven, A;Wit, FWNM;Schim van der Loeff, MF;Giera, M;Kootstra, NA;Reiss, P;Vujkovic-Cvijin, I; Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV Cell reports 2023-10-30 [PMID: 37918403] (Human)
• Höpfinger, A;Karrasch, T;Schäffler, A;Schmid, A; Circulating Concentrations of Cathelicidin Anti-Microbial Peptide (CAMP) Are Increased during Oral Glucose Tolerance Test International journal of molecular sciences 2023-08-17 [PMID: 37629082] (Human)
• Höpfinger, A;Karrasch, T;Schäffler, A;Schmid, A; Circulating Levels of Cathelicidin Antimicrobial Peptide (CAMP) Are Affected by Oral Lipid Ingestion Nutrients 2023-07-03 [PMID: 37447348] (Human)
• Coufal, S;Kverka, M;Kreisinger, J;Thon, T;Rob, F;Kolar, M;Reiss, Z;Schierova, D;Kostovcikova, K;Roubalova, R;Bajer, L;Jackova, Z;Mihula, M;Drastich, P;Tresnak Hercogova, J;Novakova, M;Vasatko, M;Lukas, M;Tlaskalova-Hogenova, H;Jiraskova Zakostelska, Z; Serum TGF-?1 and CD14 Predicts Response to Anti-TNF-? Therapy in IBD Journal of immunology research 2023-06-20 [PMID: 37383609] (Human)
• DL Tahapary, AI Fatya, F Kurniawan, C Marcella, I Rinaldi, TJE Tarigan, DS Harbuwono, E Yunir, P Soewondo, D Purnamasar Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus PLoS ONE, 2023-01-26;18(1):e0279915. 2023-01-26 [PMID: 36701395] (Human)
• L Blöbaum, M Witkowski, M Wegner, S Lammel, PA Schencke, K Jakobs, M Puccini, D Rei beta ner, D Steffens, U Landmesser, U Rauch, J Friebel Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation Biomedicines, 2023-01-10;11(1):. 2023-01-10 [PMID: 36672684] (Human)
• J Araújo Fiu, S Colt, L Gambogi de, L Ferreira M, A Gazzinelli, JF Friedman, R Corrêa-Oli The role of environmental enteric dysfunction in the pathogenesis of Schistosoma mansoni-associated morbidity in school-aged children PloS Neglected Tropical Diseases, 2022-10-05;16(10):e0010837. 2022-10-05 [PMID: 36197916] (Human)
• ML Sarangam, R Namazzi, D Datta, C Bond, CPB Vanderpool, RO Opoka, CC John, AL Conroy Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria MBio, 2022-09-07;0(0):e0132522. 2022-09-07 [PMID: 36069443] (Human)
• AI Amaruddin, JPR Koopman, M Muhammad, K Lenaerts, HMH van Eijk, EAT Brienen, AR Geelen, L van Liesho, S Wahyuni, EJ Kuijper, RD Zwittink, F Hamid, E Sartono, M Yazdanbakh Intestinal permeability before and after albendazole treatment in low and high socioeconomic status schoolchildren in Makassar, Indonesia Scientific Reports, 2022-03-01;12(1):3394. 2022-03-01 [PMID: 35233023] (Human)
• GR Ferreira, JR Santos-Oli, ML Silva-Frei, M Honda, DL Costa, AM Da-Cruz, CHN Costa Biomarkers of disease severity in patients with visceral leishmaniasis co-infected with HIV Cytokine, 2021-10-27;149(0):155747. 2021-10-27 [PMID: 34715475] (Human)
• OE Asowata, A Singh, A Ngoepe, N Herbert, R Fardoos, K Reddy, Y Zungu, F Nene, N Mthabela, D Ramjit, F Karim, K Govender, T Ndung'u, JZ Porterfiel, JH Adamson, FG Madela, VT Manzini, F Anderson, A Leslie, HN Kløverpris Irreversible depletion of intestinal CD4+ T-cells is associated with T-cell activation during chronic HIV infection JCI Insight, 2021-11-22;0(0):. 2021-11-22 [PMID: 34618690] (Human)
• A Nuzzo, K Guedj, S Curac, C Hercend, C Bendavid, N Gault, A Tran-Dinh, M Ronot, A Nicoletti, Y Bouhnik, Y Castier, O Corcos, K Peoc'h, SURVI (Str Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia Scientific Reports, 2021-09-23;11(1):18929. 2021-09-23 [PMID: 34556697] (Human)
• Tominaga T, Ikemura T, Yada K, Kanda K, Sugama K, Ma S, Choi W, Araya M, Huang J, Nakamura N, Suzuki K The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males. Antioxidants (Basel), 2021-05-28;10(6):. 2021-05-28 [PMID: 34071378] (Human)
• R Fernandez-, MW Plankey, D Ware, J Bordon Changes in liver steatosis in HIV-positive women are associated with the BMI, but not with biomarkers Cytokine, 2021-05-12;0(0):155573. 2021-05-12 [PMID: 33994069] (Human)
• S Novelli, C Lécuroux, C Goujard, J Reynes, A Villemant, L Blum, A Essat, V Avettand-F, O Launay, JM Molina, C Bourgeois, L Meyer Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection EBioMedicine, 2020-11-26;62(0):103129. 2020-11-26 [PMID: 33248370] (Human)
• R Laatikaine, H Salmenkari, T Sibakov, H Vapaatalo, A Turpeinen Randomised Controlled Trial: Partial Hydrolysation of Casein Protein in Milk Decreases Gastrointestinal Symptoms in Subjects with Functional Gastrointestinal Disorders Nutrients, 2020-07-18;12(7):. 2020-07-18 [PMID: 32708428] (Human)
• I Vujkovic-C, O Sortino, E Verheij, J Sklar, FW Wit, NA Kootstra, B Sellers, JM Brenchley, J Ananworani, MSV Loeff, Y Belkaid, P Reiss, I Sereti HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases Nat Commun, 2020-05-15;11(1):2448. 2020-05-15 [PMID: 32415070] (Human)
• C Lalande, JP Drouin-Cha, AJ Tremblay, P Couture, A Veilleux Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations Diabetol Metab Syndr, 2020-04-09;12(0):31. 2020-04-09 [PMID: 32292494] (Human)
• S Ma, T Tominaga, K Kanda, K Sugama, C Omae, S Hashimoto, K Aoyama, Y Yoshikai, K Suzuki Effects of an 8-Week Protein Supplementation Regimen with Hyperimmunized Cow Milk on Exercise-Induced Organ Damage and Inflammation in Male Runners: A Randomized, Placebo Controlled, Cross-Over Study Biomedicines, 2020-03-04;8(3):. 2020-03-04 [PMID: 32143279] (Human)
• DT Claiborne, EP Scully, CD Palmer, JL Prince, GN Macharia, J Kopycinski, CM Michelo, HW Wiener, R Parker, K Nganou-Mak, D Douek, M Altfeld, J Gilmour, MA Price, J Tang, W Kilembe, SA Allen, E Hunter Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis PLoS Pathog., 2019-08-26;15(8):e1007981. 2019-08-26 [PMID: 31449552] (Human)
• S Dirajlal-F, M Kulkarni, E Bowman, L Shan, A Sattar, N Funderburg, GA McComsey Serum Albumin Is Associated With Higher Inflammation and Carotid Atherosclerosis in Treated Human Immunodeficiency Virus Infection Open Forum Infect Dis, 2018-11-17;5(11):ofy291. 2018-11-17 [PMID: 30515432] (Human)
• Y Guillén, M Noguera-Ju, J Rivera, M Casadellà, AS Zevin, M Rocafort, M Parera, C Rodríguez, M Arumí, J Carrillo, B Mothe, C Estany, J Coll, I Bravo, C Herrero, J Saz, G Sirera, A Torrella, J Navarro, M Crespo, E Negredo, C Brander, J Blanco, ML Calle, NR Klatt, B Clotet, R Paredes Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection Mucosal Immunol, 2018-08-31;0(0):. 2018-08-31 [PMID: 30171206] (Human)
• T Booiman, FW Wit, I Maurer, D De Frances, CA Sabin, AM Harskamp, M Prins, P Garagnani, C Pirazzini, C Franceschi, D Fuchs, M Gisslén, A Winston, P Reiss, NA Kootstra High Cellular Monocyte Activation in People Living With Human Immunodeficiency Virus on Combination Antiretroviral Therapy and Lifestyle-Matched Controls Is Associated With Greater Inflammation in Cerebrospinal Fluid Open Forum Infect Dis, 2017-05-25;4(3):ofx108. 2017-05-25 [PMID: 28680905] (Human)
• Uhde M, Ajamian M, Caio G, De Giorgio R, Indart A, Green P, Verna E, Volta U, Alaedini A Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Gut, 2016-07-25;65(12):1930-1937. 2016-07-25 [PMID: 27459152] (Human)
• D Paquin-Pro, C Ching, I Vujkovic-C, D Fadrosh, L Loh, Y Huang, M Somsouk, SV Lynch, PW Hunt, DF Nixon, D SenGupta Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection Mucosal Immunol, 2016-04-06;0(0):. 2016-04-06 [PMID: 27049061] (Human)
• Claiborne , Daniel T, Prince , Jessica, Scully , Eileen, Macharia , Gladys, Micci , Luca, Lawson , Benton, Kopycinski , Jakub, Deymier , Martin J, Vanderford , Thomas H, Nganou-Makamdop , Krystell, Ende , Zachary, Brooks , Kelsie, Tang , Jianming, Yu , Tianwei, Lakhi , Shabir, Kilembe , William, Silvestri , Guido, Douek , Daniel, Goepfert , Paul A, Price , Matthew, Allen , Susan A, Paiardini , Mirko, Altfeld , Marcus, Gilmour , Jill, Hunter , Eric Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression. Proc Natl Acad Sci U S A, 2015-02-17;112(12):E1480-9. 2015-02-17 [PMID: 25730868] (Human)
• Schuetz A, Deleage C, Sereti I, Rerknimitr R, Phanuphak N, Phuang-Ngern Y, Estes J, Sandler N, Sukhumvittaya S, Marovich M, Jongrakthaitae S, Akapirat S, Fletscher J, Kroon E, Dewar R, Trichavaroj R, Chomchey N, Douek D, O Connell R, Ngauy V, Robb M, Phanuphak P, Michael N, Excler J, Kim J, de Souza M, Ananworanich J Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog, 2014-12-11;10(12):e1004543. 2014-12-11 [PMID: 25503054] (Human)

FAQs for FABP2/I-FABP (DY3078). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: FABP2