Human Erythropoietin Quantikine IVD ELISA Kit

Product Discontinued

Human Erythropoietin Quantikine IVD ELISA Kit Summary

• Background: The Quantikine^® IVD Human Epo ELISA is designed to measure Epo levels in serum or plasma in less than 4.5 hours (or less than 2.5 hours using the shaker protocol) for the quantitative determination of erythropoietin (Epo) concentration in human serum and plasma as an aid in the diagnosis of anemia and polycythemia. For in vitro diagnostic use.
• Additional Information: For In Vitro Diagnostic Use
• Specificity: Natural and recombinant human Epo
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: EPO

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with other substances.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Erythropoietin Quantikine IVD ELISA Kit

• ECYT5
• EP
• EPO
• epoetin
• Erythropoietin
• MGC138142
• MVCD2

Background

Erythropoietin (Epo), a glycoprotein (~30,400 Daltons) produced primarily by the kidney, is the principal factor regulating red blood cell production (erythropoiesis) in mammals. Renal production of Epo is regulated by changes in oxygen availability. Under conditions of hypoxia, the level of Epo in the circulation increases and this leads to increased production of red blood cells. 

The over-expression of Epo may be associated with certain pathophysiological conditions (1, 2). Polycythemia exists when there is an overproduction of red blood cells (RBCs). Primary polycythemias, such as polycythemia vera, are caused by Epo-independent growth of erythrocytic progenitors from abnormal stem cells and low to normal levels of Epo are found in the serum of affected patients. On the other hand, various types of secondary polycythemias are associated with the production of higher than normal levels of Epo. The overproduction of Epo may be an adaptive response associated with conditions that produce tissue hypoxia, such as living at high altitude, chronic obstructive pulmonary disease, cyanotic heart disease, sleep apnea, high-affinity hemoglobinopathy, smoking, or localized renal hypoxia (1, 2). In other instances, excessive Epo levels are the result of production by neoplastic cells. Cases of increased Epo production and erythrocytosis have been reported for patients with renal carcinomas (3), benign renal tumors (4), Wilms' tumors, hepatomas (5), liver carcinomas (6), cerebellar hemangioblastomas (3, 7, 8), adrenal gland tumors (9), smooth muscle tumors (3, 9), and leiomyomas (10). 

Deficient Epo production is found in conjunction with certain forms of anemias. These include anemia of renal failure and end-stage renal disease (1, 2, 11), anemias of chronic disorders [chronic infections (1), autoimmune diseases (1), rheumatoid arthritis (12), AIDS (13), malignancies (14)], anemia of prematurity (2), anemia of hypothyroidism (2), and anemia of malnutrition (2). Many of these conditions are associated with the generation of IL-1 and TNF-alpha , factors that have been shown to be inhibitors of Epo activity (1, 15). Other forms of anemias, on the other hand, are due to Epo-independent causes and affected individuals show elevated levels of Epo (2). These forms include aplastic anemias, iron deficiency anemias, thalassemias, megaloblastic anemias, pure red cell aplasias, and myelodysplastic syndromes.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Erythropoietin/EPO (DEP00)(79)

Publications using DEP00

• Navarro-Gonzales, P;Chavan, A;Wang, D;Burke, SK;Dykstra, K; A randomized trial to evaluate the pharmacokinetics, pharmacodynamics, and safety of vadadustat in patients with anemia associated with chronic kidney disease receiving hemodialysis BMC nephrology 2025-08-11 [PMID: 40790188] (Human)
• Santos-Vizcaino, E;Virumbrales-Muñoz, M;Gonzalez-Pujana, A;Luker, GD;Ochoa, I;Hernandez, RM;Pedraz, JL; Genipin-crosslinked double PLL membranes overcome the strength-diffusion trade-off in cell encapsulation without compromising biocompatibility International journal of pharmaceutics 2025-01-10 [PMID: 39799997] (Mouse)
• Odunze, U;Rustogi, N;Devine, P;Miller, L;Pereira, S;Vashist, S;Snijder, HJ;Corkill, D;Sabirsh, A;Douthwaite, J;Bond, N;Desai, A; RNA encoded peptide barcodes enable efficient in vivo screening of RNA delivery systems Nucleic acids research 2024-07-25 [PMID: 39051560] (Human, Mouse)
• Lee, Y;Jeong, M;Lee, G;Park, J;Jung, H;Im, S;Lee, H; Development of Lipid Nanoparticle Formulation for the Repeated Administration of mRNA Therapeutics Biomaterials research 2024-05-22 [PMID: 38779139] (Mouse)
• Toro, L;Rojas, V;Conejeros, C;Ayala, P;Parra-Lucares, A;Ahumada, F;Almeida, P;Silva, MF;Bravo, K;Pumarino, C;Tong, AM;Pinto, ME;Romero, C;Michea, L; A Combined Biomarker That Includes Plasma Fibroblast Growth Factor 23, Erythropoietin, and Klotho Predicts Short- and Long-Term Morbimortality and Development of Chronic Kidney Disease in Critical Care Patients with Sepsis: A Prospective Cohort Biomolecules 2023-10-03 [PMID: 37892163] (Human)
• MC Frise, DA Holdsworth, AW Johnson, YJ Chung, MK Curtis, PJ Cox, K Clarke, DJ Tyler, DJ Roberts, PJ Ratcliffe, KL Dorrington, PA Robbins Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation Scientific Reports, 2022-01-19;12(1):998. 2022-01-19 [PMID: 35046429] (Human)
• JT Royal, O Eiken, ME Keramidas, AC McDonnell, IB Mekjavic Heterogeneity of Hematological Response to Hypoxia and Short-Term or Medium-Term Bed Rest Frontiers in Physiology, 2021-12-14;12(0):777611. 2021-12-14 [PMID: 34975531] (Human)
• C Cohen, S Coulon, K Bhukhai, A Neuraz, M Dussiot, G Fouquet, ML Stang, M Flamant, F Vrtovsnik, A Hummel, B Knebelmann, L Mesnard, E Rondeau, TT Maciel, F Favale, N Casadevall, T Nguyen-Kho, S Moutereau, C Legendre, M Benhamou, RC Monteiro, O Hermine, K El Karoui, IC Moura Erythrocytosis associated with IgA nephropathy EBioMedicine, 2021-12-24;75(0):103785. 2021-12-24 [PMID: 34959131] (Human, Mouse, Transgenic Mouse)
• A Raslan, J Ciriza, AM Ochoa de R, ML Sanjuán, MS Toprak, P Galvez-Mar, L Saenz-Del-, JL Pedraz Modulation of Conductivity of Alginate Hydrogels Containing Reduced Graphene Oxide through the Addition of Proteins Pharmaceutics, 2021-09-15;13(9):. 2021-09-15 [PMID: 34575549] (Human)
• MC Man, C Ganera, GD B?rbule?, M Krzysztofi, AE Panaet, AI Cucui, DI Toh?nean, DI Alexe The Modifications of Haemoglobin, Erythropoietin Values and Running Performance While Training at Mountain vs. Hilltop vs. Seaside International Journal of Environmental Research and Public Health, 2021-09-08;18(18):. 2021-09-08 [PMID: 34574408] (Human)
• RS Riley, MV Kashyap, MM Billingsle, B White, MG Alameh, SK Bose, PW Zoltick, H Li, R Zhang, AY Cheng, D Weissman, WH Peranteau, MJ Mitchell Ionizable lipid nanoparticles for in utero mRNA delivery Science Advances, 2021-01-13;7(3):. 2021-01-13 [PMID: 33523869] (Mouse)
• A Zanchi, M Burnier, ME Muller, A Ghajarzade, M Maillard, N Loncle, B Milani, N Dufour, O Bonny, M Pruijm Acute and Chronic Effects of SGLT2 Inhibitor Empagliflozin on Renal Oxygenation and Blood Pressure Control in Nondiabetic Normotensive Subjects: A Randomized, Placebo-Controlled Trial J Am Heart Assoc, 2020-06-20;0(0):e016173. 2020-06-20 [PMID: 32567439] (Human)
• Ughetta del Balzo, Pierre E. Signore, Gail Walkinshaw, Todd W. Seeley, Mitchell C. Brenner, Qingjian Wang et al. Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease Journal of Pharmacology and Experimental Therapeutics 2020-08-01 [PMID: 32487538] (Human)
• SK Dhillon, G Wassink, CA Lear, JO Davidson, NHG Holford, AJ Gunn, L Bennet The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep Int J Mol Sci, 2020-04-25;21(9):. 2020-04-25 [PMID: 32344930] (Sheep)
• S Davidovi?, N Babi?, S Jovanovi?, S Bariši?, D Grkovi?, A Miljkovi? Serum erythropoietin concentration and its correlation with stage of diabetic retinopathy BMC Ophthalmol, 2019-11-14;19(1):227. 2019-11-14 [PMID: 31727007] (Human)
• D Montero, T Haider, J Barthelmes, JP Goetze, S Cantatore, I Sudano, F Ruschitzka, AJ Flammer Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction Physiol Rep, 2019-11-01;7(21):e14222. 2019-11-01 [PMID: 31724335] (Human)
• JM Liefhebber, R Martier, T Van der Zo, S Keskin, A Huseinovic, J Lubelski, B Blits, H Petry, P Konstantin In-Depth Characterization of a Mifepristone-Regulated Expression System for AAV5-Mediated Gene Therapy in the Liver Mol Ther Methods Clin Dev, 2019-05-16;13(0):512-525. 2019-05-16 [PMID: 31194088] (Mouse)
• D Montero, T Haider, J Barthelmes, JP Goetze, S Cantatore, C Lundby, I Sudano, F Ruschitzka, AJ Flammer Age-dependent impairment of the erythropoietin response to reduced central venous pressure in HFpEF patients Physiol Rep, 2019-03-01;7(5):e14021. 2019-03-01 [PMID: 30821129] (Human)
• K Bhat, K Sandler, S Duhachek-M, C Alli, F Cheng, NA Moatamed, CE Magyar, L Du, G Li, S McCloskey, E Vlashi, F Pajonk Serum erythropoietin levels, breast cancer and breast cancer-initiating cells Breast Cancer Res., 2019-01-30;21(1):17. 2019-01-30 [PMID: 30700319] (Human)
• Zeljka Trepotec, Johannes Geiger, Christian Plank, Manish K. Aneja, Carsten Rudolph Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life RNA 2019-04-01 [PMID: 30647100] (Human)
• NU Stoffel, M Lazrak, S Bellitir, N El Mir, A El Hamdouc, A Barkat, C Zeder, D Moretti, H Aguenaou, MB Zimmermann The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women Haematologica, 2019-01-10;0(0):. 2019-01-10 [PMID: 30630976] (Human)
• L Saenz Del, J Ciriza, A Espona-Nog, X Illa, E Cabruja, G Orive, RM Hernández, R Villa, JL Pedraz, M Alvarez 3D Printed porous polyamide macrocapsule combined with alginate microcapsules for safer cell-based therapies Sci Rep, 2018-05-31;8(1):8512. 2018-05-31 [PMID: 29855599]
• MS Kwon, BC Koo, D Kim, YH Nam, XS Cui, NH Kim, T Kim Generation of transgenic chickens expressing the human erythropoietin (hEPO) gene in an oviduct-specific manner: Production of transgenic chicken eggs containing human erythropoietin in egg whites PLoS ONE, 2018-05-30;13(5):e0194721. 2018-05-30 [PMID: 29847554] (Chicken)
• F Brunacci, VS Rocha, E De Carli, BP Espósito, R Ruano, C Colli Increased serum iron in preeclamptic women is likely due to low hepcidin levels Nutr Res, 2018-03-21;0(0):. 2018-03-21 [PMID: 29685625] (Human)
• M Yanez Arte, T Kjellman, S Bartesaghi, S Wallin, X Wu, AJ Kvist, A Dabkowska, N Székely, A Radulescu, J Bergenholt, L Lindfors Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles Proc. Natl. Acad. Sci. U.S.A., 2018-03-27;0(0):. 2018-03-27 [PMID: 29588418] (Human)
• NJ Aachmann-A, SJ Christense, K Lisbjerg, P Oturai, PI Johansson, NH Holstein-R, NV Olsen Recombinant erythropoietin acutely decreases renal perfusion and decouples the renin-angiotensin-aldosterone system Physiol Rep, 2018-03-01;6(5):. 2018-03-01 [PMID: 29504258] (Human)
• E Ferrannini, S Baldi, S Frascerra, B Astiarraga, E Barsotti, A Clerico, E Muscelli Renal Handling of Ketones in Response to Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 2 Diabetes Diabetes Care, 2017-03-21;0(0):. 2017-03-21 [PMID: 28325783] (Human)
• C Moraleda, R Aguilar, L Quintó, T Nhampossa, M Renom, A Nhabomba, S Acácio, JJ Aponte, D Nhalungo, AH Achtman, L Schofield, H Martins, E Macete, PL Alonso, C Menéndez Anaemia in hospitalised preschool children from a rural area in Mozambique: a case control study in search for aetiological agents BMC Pediatr, 2017-02-28;17(1):63. 2017-02-28 [PMID: 28241813] (Human)
• S Millot, C Delaby, B Moulouel, T Lefebvre, N Pilard, N Ducrot, C Ged, P Lett‚ron, L de Frances, JC Deybach, C Beaumont, L Gouya, H De Verneui, S Lyoumi, H Puy, Z Karim Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from G�nther disease model Haematologica, 2016-11-10;102(2):260-270. 2016-11-10 [PMID: 28143953] (Human)
• Malcolm Kohler Effect of OSA on hypoxic and inflammatory markers during CPAP withdrawal: Further evidence from three randomized control trials Respirology, 2016-11-18;0(0):. 2016-11-18 [PMID: 27860068] (Human)
• Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice Stem Cell Reports, 2016-09-08;0(0):. 2016-09-08 [PMID: 27618723] (Human)
• Diurnal changes of arterial oxygen saturation and erythropoietin concentration in male and female highlanders Physiol Rep, 2016-09-01;4(17):. 2016-09-01 [PMID: 27597764] (Human)
• Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system Gene Ther., 2016-06-30;23(10):699-707. 2016-06-30 [PMID: 27356951] (Human)
• Tonia S Rex Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa PLoS ONE, 2016-06-14;11(6):e0157411. 2016-06-14 [PMID: 27299810] (Mouse)
• ME Keramidas, IB Mekjavic, R Kölegård, A Choukèr, C Strewe, O Eiken PlanHab: Hypoxia counteracts the erythropoietin suppression, but seems to exaggerate the plasma volume reduction induced by 3�weeks of bed rest Physiol Rep, 2016-04-13;4(7):. 2016-04-13 [PMID: 27081163] (Human)
• Valente M, Denis J, Grenier N, Arvers P, Foucher B, Desangles F, Martigne P, Chaussard H, Drouet M, Abend M, Herodin F Revisiting Biomarkers of Total-Body and Partial-Body Exposure in a Baboon Model of Irradiation. PLoS ONE, 2015-07-15;10(7):e0132194. 2015-07-15 [PMID: 26177207] (Primate - Papio anubis (Olive Baboon))
• Thess A, Grund S, Mui B, Hope M, Baumhof P, Fotin-Mleczek M, Schlake T Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals. Mol Ther, 2015-06-08;23(9):1456-64. 2015-06-08 [PMID: 26050989] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• de Lucas Cerrillo A, Bond W, Rex T Safety and angiogenic effects of systemic gene delivery of a modified erythropoietin. Gene Ther, 2015-02-26;22(5):365-73. 2015-02-26 [PMID: 25716531] (Hamster)
• Flamme I, Oehme F, Ellinghaus P, Jeske M, Keldenich J, Thuss U Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS ONE, 2014-11-13;9(11):e111838. 2014-11-13 [PMID: 25392999] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Le Guiner C, Stieger K, Toromanoff A, Guilbaud M, Mendes-Madeira A, Devaux M, Guigand L, Cherel Y, Moullier P, Rolling F, Adjali O Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates. PLoS ONE, 2014-09-23;9(9):e102538. 2014-09-23 [PMID: 25248159] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Amanzada A, Goralczyk A, Reinhardt L, Moriconi F, Cameron S, Mihm S Erythropoietin rs1617640 G allele associates with an attenuated rise of serum erythropoietin and a marked decline of hemoglobin in hepatitis C patients undergoing antiviral therapy. BMC Infect Dis, 2014-09-17;14(0):503. 2014-09-17 [PMID: 25227310] (Human)
• Mercadel L, Metzger M, Haymann J, Thervet E, Boffa J, Flamant M, Vrtovsnik F, Houillier P, Froissart M, Stengel B The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease. PLoS ONE, 2014-06-30;9(6):e99781. 2014-06-30 [PMID: 24978810] (Human)
• Szygula Z, Lubkowska A, Giemza C, Skrzek A, Bryczkowska I, Dolegowska B Hematological parameters, and hematopoietic growth factors: EPO and IL-3 in response to whole-body cryostimulation (WBC) in military academy students. PLoS ONE, 2014-04-02;9(4):e93096. 2014-04-02 [PMID: 24695100] (Human)
• Wu , Sheng-Ka, Yang , Ming-Tao, Kang , Kai-Hsia, Liou , Houng-Ch, Lu , Dai-Hua, Fu , Wen-Mei, Lin , Win-Li Targeted delivery of erythropoietin by transcranial focused ultrasound for neuroprotection against ischemia/reperfusion-induced neuronal injury: a long-term and short-term study. PLoS ONE, 2014-02-28;9(2):e90107. 2014-02-28 [PMID: 24587228] (Rat)
• Zhang X, Zhang W, Ma S, Desai A, Saraf S, Miasniakova G, Sergueeva A, Ammosova T, Xu M, Nekhai S, Abbasi T, Casanova N, Steinberg M, Baldwin C, Sebastiani P, Prchal J, Kittles R, Garcia J, Machado R, Gordeuk V Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation, 2014-02-10;129(16):1650-8. 2014-02-10 [PMID: 24515990] (Human)
• Chen , Nancy, Wang , Weirong, Fauty , Scott, Fang , Yulin, Hamuro , Lora, Hussain , Azher, Prueksaritanont , Thomayan The effect of the neonatal Fc receptor on human IgG biodistribution in mice. MAbs, 2014-01-09;6(2):502-8. 2014-01-09 [PMID: 24492305] (Mouse)
• Krautkramer E, Grouls S, Hettwer D, Rafat N, Tonshoff B, Zeier M Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease. J Virol, 2013-10-23;88(1):483-9. 2013-10-23 [PMID: 24155401] (Human)
• Alexandra Castilho, Laura Neumann, Pia Gattinger, Richard Strasser, Karola Vorauer-Uhl, Thomas Sterovsky et al. Generation of Biologically Active Multi-Sialylated Recombinant Human EPOFc in Plants PLoS ONE 2013-01-25 [PMID: 23372778] (Plant - Nicotiana benthamiana)
• Bone marrow mesenchymal stem cells in patients with beta thalassemia major: molecular analysis with attenuated total reflection-Fourier transform infrared spectroscopy study as a novel method. Stem Cells Dev., 2012-02-15;21(11):2000-11. 2012-02-15 [PMID: 22214206] (Human)
• Ni W, Le Guiner C, Gernoux G Longevity of rAAV vector and plasmid DNA in blood after intramuscular injection in nonhuman primates: implications for gene doping. Gene Ther., 2011-03-10;18(7):709-18. 2011-03-10 [PMID: 21390073] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Farha S, Asosingh K, Xu W, Sharp J, George D, Comhair S, Park M, Tang WH, Loyd JE, Theil K, Tubbs R, Hsi E, Lichtin A, Erzurum SC Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities. Blood, 2011-01-21;117(13):3485-93. 2011-01-21 [PMID: 21258008] (Human)
• Labonte L, Li Y, Yang L, Gillingham A, Halpenny M, Giulivi A, Sills T, Evans K, Zanke B, Allan DS Increased plasma EPO and MIP-1 alpha are associated with recruitment of vascular progenitors but not CD34(+) cells in autologous peripheral blood stem cell grafts. Exp. Hematol., 2009-06-01;37(6):673-8. 2009-06-01 [PMID: 19463769] (Human)
• Theurl I, Aigner E, Theurl M, Nairz M, Seifert M, Schroll A, Sonnweber T, Eberwein L, Witcher DR, Murphy AT, Wroblewski VJ, Wurz E, Datz C, Weiss G Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood, 2009-03-17;113(21):5277-86. 2009-03-17 [PMID: 19293425] (Rat)
• Robach P, Recalcati S, Girelli D, Gelfi C, Aachmann-Andersen NJ, Thomsen JJ, Norgaard AM, Alberghini A, Campostrini N, Castagna A, Vigano A, Santambrogio P, Kempf T, Wollert KC, Moutereau S, Lundby C, Cairo G Alterations of systemic and muscle iron metabolism in human subjects treated with low-dose recombinant erythropoietin. Blood, 2009-03-04;113(26):6707-15. 2009-03-04 [PMID: 19264680] (Human)
• Liem-Moolenaar M, Cerneus D, Molloy C, End D, Brown K, de Kam M, Cohen A, van Hensbergen Y, Burggraaf J Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans. 2008-10-01;84(0):481. 2008-10-01 [PMID: 19238653] (Human)
• Poulsen TD, Andersen LW, Steinbruchel D, Gotze JP, Jorgensen OS, Olsen NV Two large preoperative doses of erythropoietin do not reduce the systemic inflammatory response to cardiac surgery. J. Cardiothorac. Vasc. Anesth., 2008-10-22;23(3):316-23. 2008-10-22 [PMID: 18948032] (Human)
• Zimmermann MB, Fucharoen S, Winichagoon P, Sirankapracha P, Zeder C, Gowachirapant S, Judprasong K, Tanno T, Miller JL, Hurrell RF Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia 1, or beta-thalassemia and in compound heterozygotes for HbE/beta-thalassemia. Am. J. Clin. Nutr., 2008-10-01;88(4):1026-31. 2008-10-01 [PMID: 18842790] (Human)
• Rawat R, Stoltzfus RJ, Ntozini R, Mutasa K, Iliff PJ, Humphrey JH Influence of inflammation as measured by alpha-1-acid glycoprotein on iron status indicators among HIV-positive postpartum Zimbabwean women. Eur J Clin Nutr, 2008-05-28;63(6):787-93. 2008-05-28 [PMID: 18506200] (Human)
• Klings ES, Anton Bland D, Rosenman D, Princeton S, Odhiambo A, Li G, Bernard SA, Steinberg MH, Farber HW Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression. Am. J. Hematol., 2008-07-01;83(7):547-53. 2008-07-01 [PMID: 18383329] (Human)
• Angelillo-Scherrer A, Burnier L, Lambrechts D, Fish RJ, Tjwa M, Plaisance S, Sugamele R, DeMol M, Martinez-Soria E, Maxwell PH, Lemke G, Goff SP, Matsushima GK, Earp HS, Chanson M, Collen D, Izui S, Schapira M, Conway EM, Carmeliet P Role of Gas6 in erythropoiesis and anemia in mice. J. Clin. Invest., 2008-02-01;118(2):583-96. 2008-02-01 [PMID: 18188450] (Mouse)
• Stieger K, Mendes-Madeira A, Meur GL, Weber M, Deschamps JY, Nivard D, Provost N, Moullier P, Rolling F Oral administration of doxycycline allows tight control of transgene expression: a key step towards gene therapy of retinal diseases. Gene Ther., 2007-10-04;14(23):1668-73. 2007-10-04 [PMID: 17914405] (Primate - Macaca mulatta (Rhesus Macaque))
• Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J. Am. Coll. Cardiol., 2007-06-04;49(24):2341-9. 2007-06-04 [PMID: 17572250] (Human)
• Rafat N, Hanusch C, Brinkkoetter PT, Schulte J, Brade J, Zijlstra JG, van der Woude FJ, van Ackern K, Yard BA, Beck GCh Increased circulating endothelial progenitor cells in septic patients: correlation with survival. Crit. Care Med., 2007-07-01;35(7):1677-84. 2007-07-01 [PMID: 17522579] (Human)
• Sebestyen MG, Hegge JO, Noble MA, Lewis DL, Herweijer H, Wolff JA Progress toward a nonviral gene therapy protocol for the treatment of anemia. Hum. Gene Ther., 2007-03-01;18(3):269-85. 2007-03-01 [PMID: 17376007] (Primate - Macaca mulatta (Rhesus Macaque))
• Brettschneider J, Widl K, Schattauer D, Ludolph AC, Tumani H Cerebrospinal fluid erythropoietin (EPO) in amyotrophic lateral sclerosis. Neurosci. Lett., 2007-02-03;416(3):257-60. 2007-02-03 [PMID: 17368721] (Human)
• Robach P, Cairo G, Gelfi C, Bernuzzi F, Pilegaard H, Vigano A, Santambrogio P, Cerretelli P, Calbet JA, Moutereau S, Lundby C Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood, 2007-02-20;109(11):4724-31. 2007-02-20 [PMID: 17311997] (Human)
• Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp. Hematol., 2006-10-01;34(10):1312-22. 2006-10-01 [PMID: 16982324] (Human)
• Claessens YE, Fontenay M, Pene F, Chiche JD, Guesnu M, Hababou C, Casadevall N, Dhainaut JF, Mira JP, Cariou A Erythropoiesis abnormalities contribute to early-onset anemia in patients with septic shock. Am. J. Respir. Crit. Care Med., 2006-03-30;174(1):51-7. 2006-03-30 [PMID: 16574939] (Human)
• Furstenberger G, von Moos R, Lucas R, Thurlimann B, Senn HJ, Hamacher J, Boneberg EM Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer. Br. J. Cancer, 2006-02-27;94(4):524-31. 2006-02-27 [PMID: 16450002] (Human)
• Stieger K, Le Meur G, Lasne F, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Martin L, Moullier P, Rolling F Long-term doxycycline-regulated transgene expression in the retina of nonhuman primates following subretinal injection of recombinant AAV vectors. Mol. Ther., 2006-01-25;13(5):967-75. 2006-01-25 [PMID: 16442848] (Primate - Macaca mulatta (Rhesus Macaque))
• Zamudio S, Baumann MU, Illsley NP Effects of chronic hypoxia in vivo on the expression of human placental glucose transporters. Placenta, 2006-01-01;27(1):49-55. 2006-01-01 [PMID: 16310037] (Human)
• Premawardhena A, Fisher CA, Olivieri NF, De Silva S, Arambepola M, Perera W, O'Donnell A, O'Donnell A, O'Donnell A, O'Donnell A, O'Donnell A, Peto TE, Viprakasit V, Merson L, Muraca G, Weatherall DJ Haemoglobin E beta thalassaemia in Sri Lanka. Lancet, 2005-10-01;366(9495):1467-70. 2005-10-01 [PMID: 16243092] (Human)
• Rivera VM, Gao GP, Grant RL, Schnell MA, Zoltick PW, Rozamus LW, Clackson T, Wilson JM Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer. Blood, 2004-10-26;105(4):1424-30. 2004-10-26 [PMID: 15507527] (Primate - Macaca mulatta (Rhesus Macaque))
• Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC Expansion of human SCID-repopulating cells under hypoxic conditions. J. Clin. Invest., 2003-07-01;112(1):126-35. 2003-07-01 [PMID: 12840067] (Human)
• Andreasson B, 9, Harrison C, Lindstedt G, Linch D, Kutti J Monoclonal myelopoiesis and subnormal erythropoietin concentration are independent risk factors for thromboembolic complications in essential thrombocythemia. Forward genetics in the mouse continues to be a useful and unbiased approach to identifying new genes and alleles with previously unappreciated roles in mammalian development and disease. Here, we rep, 2003-01-15;101(2):783. 2003-01-15 [PMID: 12509387] (Human)
• Ehrenreich H, Hasselblatt M, Dembowski C, Cepek L, Lewczuk P, Stiefel M, Rustenbeck HH, Breiter N, Jacob S, Knerlich F, Bohn M, Poser W, Ruther E, Kochen M, Gefeller O, Gleiter C, Wessel TC, De Ryck M, Itri L, Prange H, Cerami A, Brines M, Siren AL Erythropoietin therapy for acute stroke is both safe and beneficial. Mol. Med., 2002-08-01;8(8):495-505. 2002-08-01 [PMID: 12435860] (Human)
• Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J. Virol., 2002-11-01;76(22):11605-11. 2002-11-01 [PMID: 12388721] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))
• Capalbo S, Battista C, Delia M, Ciancio A, De Santis G, Dargenio M, Diomede D, Liso V Evaluation of tumor necrosis factor-alpha and erythropoietin serum levels in B-cell chronic lymphocytic leukemia patients with anemia. Acta Haematol., 2002-01-01;108(2):84-9. 2002-01-01 [PMID: 12187026] (Human)
• Zhou S, Murphy JE, Escobedo JA, Dwarki VJ Adeno-associated virus-mediated delivery of erythropoietin leads to sustained elevation of hematocrit in nonhuman primates. Gene Ther., 1998-05-01;5(5):665-70. 1998-05-01 [PMID: 9797871] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))

FAQs for Erythropoietin/EPO (DEP00). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: EPO