Human Erythropoietin Quantikine IVD ELISA Kit

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

Order Details

Human Erythropoietin Quantikine IVD ELISA Kit Summary

Background
The Quantikine® IVD Human Epo ELISA is designed to measure Epo levels in serum or plasma in less than 4.5 hours (or less than 2.5 hours using the shaker protocol) for the quantitative determination of erythropoietin (Epo) concentration in human serum and plasma as an aid in the diagnosis of anemia and polycythemia. For in vitro diagnostic use.
Additional Information
For In Vitro Diagnostic Use
Specificity
Natural and recombinant human Epo
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
EPO

Applications/Dilutions

Application Notes
Interference observed with other substances.
Publications
Read Publications using DEP00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Erythropoietin Quantikine IVD ELISA Kit

  • ECYT5
  • EP
  • EPO
  • epoetin
  • Erythropoietin
  • MGC138142
  • MVCD2

Background

Erythropoietin (Epo), a glycoprotein (~30,400 Daltons) produced primarily by the kidney, is the principal factor regulating red blood cell production (erythropoiesis) in mammals. Renal production of Epo is regulated by changes in oxygen availability. Under conditions of hypoxia, the level of Epo in the circulation increases and this leads to increased production of red blood cells. 
The over-expression of Epo may be associated with certain pathophysiological conditions (1, 2). Polycythemia exists when there is an overproduction of red blood cells (RBCs). Primary polycythemias, such as polycythemia vera, are caused by Epo-independent growth of erythrocytic progenitors from abnormal stem cells and low to normal levels of Epo are found in the serum of affected patients. On the other hand, various types of secondary polycythemias are associated with the production of higher than normal levels of Epo. The overproduction of Epo may be an adaptive response associated with conditions that produce tissue hypoxia, such as living at high altitude, chronic obstructive pulmonary disease, cyanotic heart disease, sleep apnea, high-affinity hemoglobinopathy, smoking, or localized renal hypoxia (1, 2). In other instances, excessive Epo levels are the result of production by neoplastic cells. Cases of increased Epo production and erythrocytosis have been reported for patients with renal carcinomas (3), benign renal tumors (4), Wilms' tumors, hepatomas (5), liver carcinomas (6), cerebellar hemangioblastomas (3, 7, 8), adrenal gland tumors (9), smooth muscle tumors (3, 9), and leiomyomas (10). 
Deficient Epo production is found in conjunction with certain forms of anemias. These include anemia of renal failure and end-stage renal disease (1, 2, 11), anemias of chronic disorders [chronic infections (1), autoimmune diseases (1), rheumatoid arthritis (12), AIDS (13), malignancies (14)], anemia of prematurity (2), anemia of hypothyroidism (2), and anemia of malnutrition (2). Many of these conditions are associated with the generation of IL-1 and TNF-alpha, factors that have been shown to be inhibitors of Epo activity (1, 15). Other forms of anemias, on the other hand, are due to Epo-independent causes and affected individuals show elevated levels of Epo (2). These forms include aplastic anemias, iron deficiency anemias, thalassemias, megaloblastic anemias, pure red cell aplasias, and myelodysplastic syndromes.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Erythropoietin/EPO (DEP00)(61)

We have publications tested in 8 confirmed species: Human, Mouse, Rat, Chicken, Hamster, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio anubis (Olive Baboon).


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Human
(43)
Mouse
(3)
Rat
(1)
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(1)
Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
(6)
Primate - Macaca mulatta (Rhesus Macaque)
(4)
Primate - Papio anubis (Olive Baboon)
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Showing Publications 1 - 10 of 61. Show All 61 Publications.
Publications using DEP00 Applications Species
S Davidovi?, N Babi?, S Jovanovi?, S Bariši?, D Grkovi?, A Miljkovi? Serum erythropoietin concentration and its correlation with stage of diabetic retinopathy BMC Ophthalmol, 2019;19(1):227. 2019 [PMID: 31727007] (Human) Human
D Montero, T Haider, J Barthelmes, JP Goetze, S Cantatore, I Sudano, F Ruschitzka, AJ Flammer Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction Physiol Rep, 2019;7(21):e14222. 2019 [PMID: 31724335] (Human) Human
D Montero, T Haider, J Barthelmes, JP Goetze, S Cantatore, C Lundby, I Sudano, F Ruschitzka, AJ Flammer Age-dependent impairment of the erythropoietin response to reduced central venous pressure in HFpEF patients Physiol Rep, 2019;7(5):e14021. 2019 [PMID: 30821129] (Human) Human
K Bhat, K Sandler, S Duhachek-M, C Alli, F Cheng, NA Moatamed, CE Magyar, L Du, G Li, S McCloskey, E Vlashi, F Pajonk Serum erythropoietin levels, breast cancer and breast cancer-initiating cells Breast Cancer Res., 2019;21(1):17. 2019 [PMID: 30700319] (Human) Human
NU Stoffel, M Lazrak, S Bellitir, N El Mir, A El Hamdouc, A Barkat, C Zeder, D Moretti, H Aguenaou, MB Zimmermann The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women Haematologica, 2019;0(0):. 2019 [PMID: 30630976] (Human) Human
L Saenz Del, J Ciriza, A Espona-Nog, X Illa, E Cabruja, G Orive, RM Hernández, R Villa, JL Pedraz, M Alvarez 3D Printed porous polyamide macrocapsule combined with alginate microcapsules for safer cell-based therapies Sci Rep, 2018;8(1):8512. 2018 [PMID: 29855599]
MS Kwon, BC Koo, D Kim, YH Nam, XS Cui, NH Kim, T Kim Generation of transgenic chickens expressing the human erythropoietin (hEPO) gene in an oviduct-specific manner: Production of transgenic chicken eggs containing human erythropoietin in egg whites PLoS ONE, 2018;13(5):e0194721. 2018 [PMID: 29847554] (Chicken) Chicken
F Brunacci, VS Rocha, E De Carli, BP Espósito, R Ruano, C Colli Increased serum iron in preeclamptic women is likely due to low hepcidin levels Nutr Res, 2018;0(0):. 2018 [PMID: 29685625] (Human) Human
M Yanez Arte, T Kjellman, S Bartesaghi, S Wallin, X Wu, AJ Kvist, A Dabkowska, N Székely, A Radulescu, J Bergenholt, L Lindfors Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 29588418] (Human) Human
NJ Aachmann-A, SJ Christense, K Lisbjerg, P Oturai, PI Johansson, NH Holstein-R, NV Olsen Recombinant erythropoietin acutely decreases renal perfusion and decouples the renin-angiotensin-aldosterone system Physiol Rep, 2018;6(5):. 2018 [PMID: 29504258] (Human) Human
Show All 61 Publications.

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FAQs for Erythropoietin/EPO (DEP00). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

HRP DEP00

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Bioinformatics

Gene Symbol EPO